Solendovirus

VIRION

Non enveloped, large (50 nm diameter) icosahedral particles with a T=7 symmetry composed of 420 subunits. It has not been described whether handedness of capsid is laevo or dextro, here the pictures dsplays a laevo form.

GENOME

Monopartite, open circular, double stranded DNA of 7.7 kb. with each strand of viral DNA being interrupted by a site-specific discontinuity. ORF1 codes for the capsid protein, ORF2 for a movement protein, ORF3 for a replicase polyprotein and ORF4 product is a transactivator.

GENE EXPRESSION

REPLICATION

CYTOPLASMIC NUCLEAR

  1. Attachment of the viral proteins to host receptors mediates its entry into the host cell.
  2. The viral dsDNA is released into the nucleus where it is transcribed by host RNA polymerase II
  3. RNA translation produces viral proteins.
  4. Genomic RNA is retrotranscribed in the cytoplasm into new dsDNA genomes
  5. Genomes are encapsidated with capsid protein, releasing new virions.