Caliciviridae

VIRION

Non-enveloped, capsid of about 27-40 nm in diameter, with T=3 icosahedral symmetry. The capsid is composed of 180 capsid proteins.

GENOME

Monopartite, linear ssRNA(+) genome of 7.3 to 8.3 kb. The 5'-terminus is linked to a VPg protein and the 3'-terminus has a poly(A) tract.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. The genome encodes a polyprotein (ORF1). One or two smaller ORFs are expressed from a subgenomic RNA. Cleavage of ORF1 polyprotein by the virus-encoded 3C-like cysteine proteinase yields the mature nonstructural proteins. The 3'-end terminal ORF encodes a basic protein (and the capsid protein) and is expressed through RNA termination-reinitiation.
Some Norovirus expressan alternative ORF by leaky scanning Vesiviruses are apparently unique among the Caliciviridae in that the ORF2 encodes a capsid precursor protein that is proteolytically processed by the viral proteinase to yield the mature capsid protein.

REPLICATION

CYTOPLASMIC

  1. Attachement to host receptors mediates endocytosis of the virus into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. VPg is removed from the viral RNA, which is then translated into a processed ORF1 polyprotein to yield the replication proteins.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Subgenomic RNA translation gives rise to the capsid protein and VP2.
  7. Assembly of new virus particles and release by cell lysis.

Host-virus interaction

Apoptosis modulation

Murine norovirus and rabbit hemorrhagic disease virus induce host cell apoptosis .

Host gene expression shutoff by virus

Noroviruses and Vesiviruses mediate host translation shutoff by cleaving PABP1 .

Matching UniProtKB/Swiss-Prot entries

55 entries grouped by strain (browse by keywords)

All proteins are shown (view only 45 complete proteome entries)

3 entries

Feline calicivirus (strain Cat/United States/Urbana/1960) (FCV) reference strain

Select_allDeselect_all
CAPSD_FCVUR Capsid protein (Coat protein) (CP) [Cleaved into: Protein 40k]
VP2_FCVUR Protein VP2 (Minor capsid protein)
POLG_FCVUR Genome polyprotein [Cleaved into: Protein p5.6; Protein p32; NTPase (EC 3.6.1.15) (p39); Protein ...

3 entries

Norwalk virus (strain GI/Human/United States/Norwalk/1968) (Hu/NV/NV/1968/US) reference strain

Select_allDeselect_all
CAPSD_NVN68 Capsid protein VP1 (CP) (p59) [Cleaved into: Soluble capsid protein (Protein 30k) (p30)]
POLG_NVN68 Genome polyprotein [Cleaved into: Protein p48; NTPase (EC 3.6.1.15) (p41); Protein p22; Viral ...
VP2_NVN68 Protein VP2 (Minor capsid protein)

3 entries

Sapporo virus (isolate GI/Human/Germany/pJG-Sap01) (Hu/Dresden/pJG-Sap01/DE) reference strain

Select_allDeselect_all
VP3_SVSAP Uncharacterized protein VP3
VP2_SVSAP Protein VP2 (Minor capsid protein)
POLG_SVSAP Genome polyprotein [Cleaved into: Protein p11; Protein p28; NTPase (EC 3.6.1.15) (p35); Protein p32; ...

3 entries

Vesicular exanthema of swine virus serotype A48 (isolate Swine/United States/A48/1948) (VESV) reference strain

Select_allDeselect_all
CAPSD_VESVA Capsid protein (CP) (Coat protein) (VP1)
POLG_VESVA Genome polyprotein [Cleaved into: Protein p16; Protein p32; NTPase (EC 3.6.1.15) (p39); Protein p30; ...
VP2_VESVA Protein VP2 (Minor capsid protein)

2 entries

Bovine enteric calicivirus Newbury agent-1 (isolate Bovine/UK/Newbury1/1976) (BEC) reference strain

Select_allDeselect_all
VP2_BECN1 Protein VP2 (Minor capsid VP2)
POLG_BECN1 Genome polyprotein [Cleaved into: Protein p34; NTPase (EC 3.6.1.15) (p37); Protein p30; Viral ...

2 entries

Rabbit hemorrhagic disease virus (strain Rabbit/Germany/FRG/1989) (Ra/LV/RHDV/GH/1989/GE) (RHDV-FRG) reference strain

Select_allDeselect_all
VP2_RHDVF Protein VP2 (Minor capsid protein)
POLG_RHDVF Genome polyprotein (p254) [Cleaved into: Protein p16; Protein p23; NTPase (EC 3.6.1.15) (2C-like ...

3 entries

Canine calicivirus (strain 48) (CaCV)

Select_allDeselect_all
CAPSD_CACV4 Capsid protein (Coat protein) (CP) (VP1)
VP2_CACV4 Protein VP2 (Minor capsid protein)
POLG_CACV4 Genome polyprotein [Cleaved into: Protein p18; Protein p32; NTPase (EC 3.6.1.15) (p39); Protein p30; ...

3 entries

Feline calicivirus (strain CFI/68 FIV) (FCV)

Select_allDeselect_all
CAPSD_FCVC6 Capsid protein (Coat protein) (CP) (VP1) [Cleaved into: Protein 40k]
VP2_FCVC6 Protein VP2 (Minor capsid protein)
POLG_FCVC6 Genome polyprotein [Cleaved into: Protein p5.6; Protein p32; NTPase (EC 3.6.1.15) (p39); Protein ...

3 entries

Feline calicivirus (strain F9) (FCV)

Select_allDeselect_all
CAPSD_FCVF9 Capsid protein (Coat protein) (CP) (VP1) [Cleaved into: Protein 40k]
VP2_FCVF9 Protein VP2 (Minor capsid protein)
POLG_FCVF9 Genome polyprotein [Cleaved into: Protein p5.6; Protein p32; NTPase (EC 3.6.1.15) (p39); Protein ...

3 entries

Feline calicivirus (strain Japanese F4) (FCV)

Select_allDeselect_all
CAPSD_FCVF4 Capsid protein (Coat protein) (CP) (VP1) [Cleaved into: Protein 40k]
VP2_FCVF4 Protein VP2 (Minor capsid protein)
POLG_FCVF4 Genome polyprotein [Cleaved into: Protein p5.6; Protein p32; NTPase (EC 3.6.1.15) (p39); Protein ...

3 entries

Lordsdale virus (strain GII/Human/United Kingdom/Lordsdale/1993) (Human enteric calicivirus) (Hu/NV/LD/1993/UK)

Select_allDeselect_all
CAPSD_LORDV Capsid protein (CP) (VP1) [Cleaved into: Soluble capsid protein]
VP2_LORDV Protein VP2 (Minor capsid protein)
POLG_LORDV Genome polyprotein [Cleaved into: Protein p37; NTPase (EC 3.6.1.15) (p40); Protein p20; Viral ...

3 entries

San Miguel sea lion virus serotype 1 (SMSV-1) (SMSV serotype 1)

Select_allDeselect_all
CAPSD_SMSV1 Capsid protein (Coat protein) (CP) (VP1)
VP2_SMSV1 Protein VP2 (Minor capsid protein)
POLG_SMSV1 Genome polyprotein [Cleaved into: Protein p16; Protein p32; NTPase (EC 3.6.1.15) (p39); Protein p30; ...

3 entries

Southampton virus (strain GI/Human/United Kingdom/Southampton/1991) (SHV) (Hu/NV/SHV/1991/UK)

Select_allDeselect_all
CAPSD_SOUV3 Capsid protein VP1 (CP) [Cleaved into: Soluble capsid protein]
VP2_SOUV3 Protein VP2 (Minor capsid protein)
POLG_SOUV3 Genome polyprotein [Cleaved into: Protein p48; NTPase (EC 3.6.1.15) (p41); Protein p22; Viral ...

2 entries

Bovine enteric calicivirus NB (isolate Bovine/United States/Nebraska/1980) (BEC-NB)

Select_allDeselect_all
VP2_BECNB Protein VP2 (Minor capsid protein)
POLG_BECNB Genome polyprotein [Cleaved into: Protein p34; NTPase (EC 3.6.1.15) (p37); Protein p30; Viral ...

2 entries

Porcine enteric sapovirus (isolate Swine/United States/Cowden/1980) (Sw/SV/Cowden/1980/US)

Select_allDeselect_all
VP2_PESV Protein VP2 (Minor capsid protein)
POLG_PESV Genome polyprotein [Cleaved into: Protein p11; Protein p28; NTPase (EC 3.6.1.15) (p35); Protein p32; ...

2 entries

Rabbit hemorrhagic disease virus (strain AST89) (Ra/LV/RHDV/AST89/1989/SP) (RHDV-AST89)

Select_allDeselect_all
VP2_RHDVA Protein VP2 (Minor capsid protein)
POLG_RHDVA Genome polyprotein (p254) [Cleaved into: Protein p16; Protein p23; NTPase (EC 3.6.1.15) (2C-like ...

2 entries

Rabbit hemorrhagic disease virus (strain V-351) (Ra/LV/RHDV/V351/1991/CK) (RHDV-V351)

Select_allDeselect_all
VP2_RHDV3 Protein VP2 (Minor capsid protein)
POLG_RHDV3 Genome polyprotein (p254) [Cleaved into: Protein p16; Protein p23; NTPase (EC 3.6.1.15) (2C-like ...

2 entries

San Miguel sea lion virus serotype 4 (SMSV-4) (SMSV serotype 4)

Select_allDeselect_all
CAPSD_SMSV4 Capsid protein (Coat protein) (CP) (VP1)
VP2_SMSV4 Protein VP2 (Minor capsid protein)

2 entries

Sapporo virus (isolate GII/Human/Thailand/Mc10/2000) (Hu/SaV/Mc10/2000/Thailand)

Select_allDeselect_all
VP2_SVM10 Protein VP2 (Minor capsid protein)
POLG_SVM10 Genome polyprotein [Cleaved into: Protein p11; Protein p28; NTPase (EC 3.6.1.15) (p35); Protein p32; ...

2 entries

Sapporo virus (strain Human/United Kingdom/Manchester/1993) (Hu/SV/Man/1993/UK)

Select_allDeselect_all
VP2_SVM93 Protein VP2 (Minor capsid protein)
VP3_SVM93 Uncharacterized protein VP3

1 entry

European brown hare syndrome virus (strain GD) (Ha/LV/EBHSV/GD/1989/FR) (EBHSV-GD)

POLG_EBHSG Genome polyprotein (p254) [Cleaved into: Protein p16; Protein p23; NTPase (EC 3.6.1.15) (2C-like ...

1 entry

Rabbit calicivirus (Ra/LV/RHDV/RCV/1995/IT) (RHDV)

CAPSD_RHDVR Subgenomic capsid protein VP60

1 entry

Rabbit hemorrhagic disease virus (strain BS89) (Ra/LV/RHDV/BS89/1989/IT) (RHDV-BS89)

POLG_RHDVB Genome polyprotein (p254) [Cleaved into: Protein p16; Protein p23; NTPase (EC 3.6.1.15) (2C-like ...

1 entry

Rabbit hemorrhagic disease virus (strain SD) (Ra/LV/RHDV/SD/1989/FR) (RHDV-SD)

POLG_RHDVS Genome polyprotein (p254) [Cleaved into: Protein p16; Protein p23; NTPase (EC 3.6.1.15) (2C-like ...