Viral short tail ejection system

The short tail of Podoviridae acts as a molecular machine that ejects the viral DNA from the capsid into the host cell cytoplasm. The ejection system consists of a central tube, the connector which attaches the tail to the phage capsid and released inner core proteins .

Upon binding to the host cell surface, podoviruses display a tube-like extension of their short tail that penetrates both host membranes. This tail extension comes from the release of viral core proteins with channel forming properties .

The source of the forces that drive viral genome ejection is probably in part due to osmotic pressure imbalance between the virus inside and the host cytoplasm .

Gram(-) hosts:

  1. Attachment to a host cell outer membrane (OM) receptor.
  2. Ejection proteins in the head form a channel that penetrates the OM. Virion-associated exolysin (if present) hydrolyzes the peptidoglycan layer.
  3. Channel extends through the inner membrane (IM). Some viruses may use an IM receptor.
  4. Viral DNA translocation into the host cytoplasm.

Gram(+) hosts:

  1. Attachment to a host cell wall receptor.
  2. Virion-associated exolysin (if present)hydrolyzes the peptidoglycan layer.
  3. ? Channel formation or tunneling of a way through the host cell wall ?
  4. Viral DNA translocation into the host cytoplasm.

Matching UniProtKB/Swiss-Prot entries

32 entries grouped by protein (browse by keywords)

All proteins are shown (view only 31 complete proteome entries)

4 entries

Tail knob protein gp9 (Distal tube protein) (Gene product 9) (gp9) (Protein p9)

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DIT9_BPNF
Bacillus phage Nf (Bacteriophage Nf) reference strain

Tail knob protein gp9 (Distal tube protein) (Gene product 9) (gp9) (Protein p9) (Tail protein)

DIT9_BPPH2
Bacillus phage phi29 (Bacteriophage phi-29) reference strain
DIT9_BPB03
Bacillus phage B103 (Bacteriophage B103)
DIT9_BPPZA
Bacillus phage PZA (Bacteriophage PZA)

5 entries

Peptidoglycan hydrolase gp16 (EC 4.2.2.n1) (Gene product 16) (Gp16) (Internal virion protein gp16)

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EXLYS_BPAPS
Acyrthosiphon pisum secondary endosymbiont phage 1 (Bacteriophage APSE-1) reference strain

Peptidoglycan hydrolase gp27 (Gene product 27) (Gp27) (Internal virion protein gp27)

EXLYS_BPKMV
Pseudomonas phage phiKMV reference strain

Peptidoglycan hydrolase gp36 (EC 3.2.1.17) (Gene product 36) (Gp36)

EXLYS_BPP22
Salmonella phage P22 (Bacteriophage P22) reference strain

Peptidoglycan hydrolase gp4 (Gene product 4) (Gp4) (Internal virion protein gp4)

EXLYS_BPSP6
Enterobacteria phage SP6 (Bacteriophage SP6) reference strain

Peptidoglycan hydrolase gp36 (Gene product 36) (Gp36)

EXLYS_BPT7
Enterobacteria phage T7 (Bacteriophage T7) reference strain

1 entry

Morphogenesis protein 1 (Gene product 13) (gp13) (Protein p13)

GP13_BPPH2
Bacillus phage phi29 (Bacteriophage phi-29) reference strain

1 entry

Internal virion protein gp14 (Gene product 14) (Gp14)

GP14_BPT7
Enterobacteria phage T7 (Bacteriophage T7) reference strain

1 entry

Internal virion protein gp15 (Gene product 15) (Gp15)

GP15_BPT7
Enterobacteria phage T7 (Bacteriophage T7) reference strain

1 entry

Tail needle protein gp26 (Head completion protein) (Packaged DNA stabilization protein) (Tail accessory factor gp26)

NEEDL_BPP22
Salmonella phage P22 (Bacteriophage P22) reference strain

14 entries

Portal protein (Head-to-tail connector)

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PORTL_BP44A
Staphylococcus phage 44AHJD reference strain

Portal protein (Connector protein) (Gene product 19) (gp19) (Head-to-tail connector) (Probable portal protein) (Upper collar protein)

PORTL_BPAPS
Acyrthosiphon pisum secondary endosymbiont phage 1 (Bacteriophage APSE-1) reference strain

Portal protein (Gene product 19) (Gp19) (Head-to-tail connector)

PORTL_BPBPP
Bordetella phage BPP-1 reference strain

Probable portal protein (Gene product 21) (gp21) (Head-to-tail connector)

PORTL_BPE15
Salmonella phage epsilon15 reference strain
PORTL_BPKHP
Helicobacter pylori bacteriophage KHP30 reference strain

Portal protein (Head-to-tail connector gp8) (Putative portal protein ORF17)

PORTL_BPKMV
Pseudomonas phage phiKMV reference strain
PORTL_BPN4
Enterobacteria phage N4 (Bacteriophage N4) reference strain

Probable portal protein (94 kDa protein) (Gene product 59) (gp59) (Head-to-tail connector)

PORTL_BPP22
Salmonella phage P22 (Bacteriophage P22) reference strain

Portal protein (Gene product 1) (Gp1) (Head-to-tail connector)

PORTL_BPPH2
Bacillus phage phi29 (Bacteriophage phi-29) reference strain

Portal protein (Connector protein) (Gene product 10) (gp10) (Gene product 19) (gp19) (Head-to-tail connector) (Probable portal protein) (Protein p10) (Upper collar protein)

PORTL_BPSP6
Enterobacteria phage SP6 (Bacteriophage SP6) reference strain
PORTL_BPT7
Enterobacteria phage T7 (Bacteriophage T7) reference strain

Portal protein (Gene product 8) (Gp8) (Head-to-tail connector gp8)

PORTL_BPB03
Bacillus phage B103 (Bacteriophage B103)

Portal protein (Gene product 10) (gp10) (Head-to-tail connector) (Upper collar protein)

PORTL_BPPZA
Bacillus phage PZA (Bacteriophage PZA)

Portal protein (Connector protein) (Gene product 10) (gp10) (Gene product 19) (gp19) (Head-to-tail connector) (Probable portal protein) (Protein p10) (Upper collar protein)

PORTL_BPT3
Enterobacteria phage T3 (Bacteriophage T3)

Portal protein (Gene product 8) (Gp8) (Head-to-tail connector gp8) (Head-to-tail joining protein)

3 entries

Proximal tail tube connector protein (Gene product 11) (gp11) (Lower collar protein) (Protein p11)

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TUB11_BPPH2
Bacillus phage phi29 (Bacteriophage phi-29) reference strain
TUB11_BPB03
Bacillus phage B103 (Bacteriophage B103)
TUB11_BPPZA
Bacillus phage PZA (Bacteriophage PZA)

1 entry

Tail tubular protein gp11 (Gene product 11) (Gp11)

TUBE1_BPT7
Enterobacteria phage T7 (Bacteriophage T7) reference strain

1 entry

Tail tubular protein gp12 (Gene product 12) (Gp12)

TUBE2_BPT7
Enterobacteria phage T7 (Bacteriophage T7) reference strain