Orthohepevirus

VIRION

Non-enveloped, spherical, about 32-34 nm in diameter. The RNA genome is enclosed within a capsid that is composed of 60 capsid proteins, assembled into a T=1 icosahedral particle.

GENOME

Monopartite, linear, ssRNA(+) genome of 7.2 kb. The 5' end is capped and the 3' terminus is polyadenylated. Their is no VPg at the 5'-terminus of the genome. The genome consists of three partially overlapping ORFs.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. ORF 1 encodes the nonstructural proteins, it is not clear wether this polyprotein is cleaved or not; ORF 2 encodes the capsid protein; ORF 3 encodes a small immunogenic protein. ORF2 is translated by leaky scanning from the bicistronic ORF3-2 subgenomic RNA.

REPLICATION

  1. Attachement of the virus to host receptors mediates internalization into the host cell by clathrin-mediated endocytosis.
  2. RNA genome is released into the cytoplasm.
  3. The positive-sense genomic ssRNA is translated into a processed ORF1 polyprotein to yield the mature non-structural proteins involved in RNA transcription.
  4. Replication takes place in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Expression of two other messenger RNAs, a 3.7 kb subgenomic one and a 2.0 kb coterminal one.
  7. Virus assembly and release.

Host-virus interaction

Innate immune response inhibition

HEV ORF3 protein suppresses host interferon-α signaling by inhibiting STAT1 phosphorylation .

Matching UniProtKB/Swiss-Prot entries

27 entries grouped by protein (browse by keywords)

9 entries

Capsid protein (Protein ORF2) (pORF2)

Select_allDeselect_all
CAPSD_HEVCH
Hepatitis E virus genotype 1 (isolate Human/China/HeBei/1987) (HEV) reference strain
CAPSD_HEVBU
Hepatitis E virus genotype 1 (isolate Human/Burma) (HEV-1)
CAPSD_HEVCT
Hepatitis E virus genotype 4 (isolate Human/China/T1) (HEV-4) (Hepatitis E virus genotype 4 (isolate Human/China/Ct1))
CAPSD_HEVHY
Hepatitis E virus genotype 1 (isolate Human/India/Hyderabad) (HEV-1)
CAPSD_HEVME
Hepatitis E virus genotype 2 (isolate Human/Mexico) (HEV-2)
CAPSD_HEVMG
Hepatitis E virus genotype 3 (isolate Swine/United States/swUS1) (HEV-3) (Hepatitis E virus genotype 3 (isolate Swine/United States/Meng))
CAPSD_HEVMY
Hepatitis E virus genotype 1 (isolate Human/Myanmar/HEVNE8L) (HEV-1)
CAPSD_HEVPA
Hepatitis E virus genotype 1 (isolate Human/Pakistan/Sar-55) (HEV-1)
CAPSD_HEVUS
Hepatitis E virus genotype 3 (isolate Human/United States/US2) (HEV-3)

9 entries

Protein ORF3 (pORF3)

Select_allDeselect_all
ORF3_HEVCH
Hepatitis E virus genotype 1 (isolate Human/China/HeBei/1987) (HEV) reference strain
ORF3_HEVBU
Hepatitis E virus genotype 1 (isolate Human/Burma) (HEV-1)
ORF3_HEVCT
Hepatitis E virus genotype 4 (isolate Human/China/T1) (HEV-4) (Hepatitis E virus genotype 4 (isolate Human/China/Ct1))
ORF3_HEVHY
Hepatitis E virus genotype 1 (isolate Human/India/Hyderabad) (HEV-1)
ORF3_HEVME
Hepatitis E virus genotype 2 (isolate Human/Mexico) (HEV-2)
ORF3_HEVMG
Hepatitis E virus genotype 3 (isolate Swine/United States/swUS1) (HEV-3) (Hepatitis E virus genotype 3 (isolate Swine/United States/Meng))
ORF3_HEVMY
Hepatitis E virus genotype 1 (isolate Human/Myanmar/HEVNE8L) (HEV-1)
ORF3_HEVPA
Hepatitis E virus genotype 1 (isolate Human/Pakistan/Sar-55) (HEV-1)
ORF3_HEVUS
Hepatitis E virus genotype 3 (isolate Human/United States/US2) (HEV-3)

9 entries

Non-structural polyprotein pORF1

Select_allDeselect_all
POLN_HEVCH
Hepatitis E virus genotype 1 (isolate Human/China/HeBei/1987) (HEV) reference strain
POLN_HEVBU
Hepatitis E virus genotype 1 (isolate Human/Burma) (HEV-1)
POLN_HEVCT
Hepatitis E virus genotype 4 (isolate Human/China/T1) (HEV-4) (Hepatitis E virus genotype 4 (isolate Human/China/Ct1))
POLN_HEVHY
Hepatitis E virus genotype 1 (isolate Human/India/Hyderabad) (HEV-1)
POLN_HEVME
Hepatitis E virus genotype 2 (isolate Human/Mexico) (HEV-2)
POLN_HEVMG
Hepatitis E virus genotype 3 (isolate Swine/United States/swUS1) (HEV-3) (Hepatitis E virus genotype 3 (isolate Swine/United States/Meng))
POLN_HEVMY
Hepatitis E virus genotype 1 (isolate Human/Myanmar/HEVNE8L) (HEV-1)
POLN_HEVPA
Hepatitis E virus genotype 1 (isolate Human/Pakistan/Sar-55) (HEV-1)
POLN_HEVUS
Hepatitis E virus genotype 3 (isolate Human/United States/US2) (HEV-3)