Inhibition of host IKBKE by virus

Upon activation of viral RNA sensors, such as RIG-I-like receptors, IKK-epsilon associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli.


Several viruses including arenaviruses or ebola virus interact directly with and inhibit IKBKE/IKK-epsilon to prevent IRFs activation. Engagement of arenavirus nucleocapsid protein seems to sequester IKKepsilon in an inactive complex while VP35 from ebola virus interferes with the interaction between Ikkepsilon and IRF3/IRF7 substrates.

Inhibition of MDA5/RIG-I pathway Inhibition of RIG-I
Inhibition of MDA5
Inhibition of MAVS
Inhibition of IKKepsilon
Inhibition of host IRF3
Inhibition of host IRF7
Links Uniprot Keyword: KW-1224
GO ontology: GO:0039724
Virus -Arenaviruses
(Arenaviridae, Arenavirus )

-Ebolavirus
(Filoviridae, Ebolavirus )

-Dengue virus
(Flaviviridae, Flavivirus )

Matching UniProtKB/Swiss-Prot entries

31 entries grouped by protein (browse by keywords)

All proteins are shown (view only 26 complete proteome entries)

23 entries

Nucleoprotein (Nucleocapsid protein) (Protein N)

Select_allDeselect_all
NCAP_LASSJ
Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain
NCAP_LATVB
Latino mammarenavirus (isolate Rat/Bolivia/MARU 1924/1965) (LATV) reference strain
NCAP_LYCVA
Lymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain
NCAP_PIRVV
Pirital mammarenavirus (isolate Rat/Venezuela/VAV-488/1995) (PIRV) reference strain
NCAP_TACVF
Tacaribe virus (strain Franze-Fernandez) (TCRV) reference strain
NCAP_ALLVP
Allpahuayo mammarenavirus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)
NCAP_BCNVU
Bear Canyon mammarenavirus (isolate Mouse/United States/AV A0070039/2000) (BCNV)
NCAP_CHAVB
Chapare mammarenavirus (isolate Human/Bolivia/810419/2003)
NCAP_CPXVB
Cupixi mammarenavirus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)
NCAP_GTOVV
Guanarito mammarenavirus (isolate Human/Venezuela/NH-95551/1990) (GTOV)
NCAP_IPPYV
Ippy mammarenavirus (isolate Rat/Central African Republic/Dak An B 188 d/1970) (IPPYV)
NCAP_JUNIN
Junin mammarenavirus (JUNV) (Junn mammarenavirus)
NCAP_LASSG
Lassa virus (strain GA391) (LASV)
NCAP_LYCVW
Lymphocytic choriomeningitis virus (strain WE) (LCMV)
NCAP_MACHU
Machupo virus (MACV)

Nucleoprotein (Protein N) (Nucleocapsid protein)

NCAP_MOBVC
Mobala mammarenavirus (isolate Rat/Central African Republic/Acar 3080/1983) (MOBV)
NCAP_MOPEI
Mopeia virus (MOPV)
NCAP_OLVVA
Oliveros mammarenavirus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)
NCAP_PARVP
Parana mammarenavirus (isolate Rat/Paraguay/12056/1965) (PARV) (Paran mammarenavirus)
NCAP_PIARV
Pichinde mammarenavirus (PICV) (Pichind mammarenavirus)
NCAP_SABVB
Sabia mammarenavirus (isolate Human/Brasil/SPH114202/1990) (SABV) (Sabi mammarenavirus)
NCAP_TAMVU
Tamiami mammarenavirus (isolate Rat/United States/W 10777/1964) (TAMV)
NCAP_WWAVU
Whitewater Arroyo mammarenavirus (isolate Rat/United States/AV 9310135/1995) (WWAV)

3 entries

Non-structural protein ORF4b (ORF4b)

Select_allDeselect_all
ORF4B_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
ORF4B_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
ORF4B_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain

5 entries

Polymerase cofactor VP35

Select_allDeselect_all
VP35_EBOZM
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain
VP35_EBORE
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
VP35_EBORR
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
VP35_EBOSU
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
VP35_EBOZ5
Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)