Tibrovirus

VIRION

Enveloped, bullet shaped.

GENOME

Negative-stranded RNA linear genome,about 13.2 kb in size. Encodes for 8 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription , viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Matching UniProtKB/Swiss-Prot entries

9 entries grouped by strain (browse by keywords)

9 entries

Tibrogargan virus (strain CS132) (TIBV) reference strain

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GLYCO_TIBVC Glycoprotein
L_TIBVC RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_TIBVC Matrix protein
NCAP_TIBVC Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_TIBVC Phosphoprotein (P protein)
U3_TIBVC Protein U3
U4_TIBVC Uncharacterized protein U4
U2_TIBVC Protein U2
U1_TIBVC Protein U1