HIV-1 reverse transcriptase (RT)

RT RT RNase RNase
FUNCTION
    Shortly after virus entry into the cell, converts the viral ssRNA genome into dsDNA, which can then be integrated into the host genome. RT is a heterodimer p66/p51 and displays multiple enzymatic activities: RNA-dependent and DNA-dependent DNA polymerase and RNase H activities .
INTERACTIONS
    Viral integrase and host proteins AKAP-149 .
SUBCELLULAR LOCATION
  • Virion
  • Host cytoplasm: reverse transcription probably takes place in the cytoplasm during capsid transport and uncoating .
  • Nucleus
TIMING OF EXPRESSION
    Late