Mardivirus

VIRION

Enveloped, spherical to pleomorphic, 120-200 nm in diameter T=16 icosahedral symmetry. The capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embedded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 175 kbp. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' nontranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

There are three types of genes: immediate-early, early and late. The immediate-early genes are transcribed immediately after infection and ensure the transcription of early genes, which encode the proteins necessary for the viral replication. The late genes mostly encode structural proteins. Standing apart are genes expressed during latency.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral gB, gC, gD and gH proteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Cell-cycle modulation

The conserved UL24 family of human alpha, beta and gamma herpesviruses induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex. Marek disease virus encodes an UL24 homolog that should fullfill this role.

Apoptosis modulation

MEQ antagonizes apoptosis possibly through regulation of its downstream target genes involved in apoptotic and/or anti-apoptotic pathways.

Host splicing inhibition

GaHV-2 MDV068 is an alternative splicing regulator of host mRNA.

Matching UniProtKB/Swiss-Prot entries

115 entries grouped by strain (browse by keywords)

All proteins are shown (view only 90 complete proteome entries)

90 entries

Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) reference strain

Select_allDeselect_all
AN_GAHVM Alkaline nuclease (EC 3.1.-.-)
CEP3_GAHVM Cytoplasmic envelopment protein 3
CEP2_GAHVM Cytoplasmic envelopment protein 2
CEP1_GAHVM Cytoplasmic envelopment protein 1
CVC1_GAHVM Capsid vertex component 1
CVC2_GAHVM Capsid vertex component 2
DPOL_GAHVM DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
DNBI_GAHVM Major DNA-binding protein
DUT_GAHVM Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
EV45_GAHVM Envelope protein UL45 homolog
GD_GAHVM Envelope glycoprotein D (gD)
GL_GAHVM Envelope glycoprotein L (gL)
GC_GAHVM Envelope glycoprotein C homolog (A antigen) (Glycoprotein A) (GA) (Secretory glycoprotein GP57-65)
GB_GAHVM Envelope glycoprotein B (gB)
GE_GAHVM Envelope glycoprotein E (gE)
GH_GAHVM Envelope glycoprotein H (gH)
GI_GAHVM Envelope glycoprotein I
GK_GAHVM Envelope glycoprotein K
GM_GAHVM Envelope glycoprotein M (gM)
GN_GAHVM Envelope glycoprotein N
LTP_GAHVM Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
NEC1_GAHVM Nuclear egress protein 1
NEC2_GAHVM Nuclear egress protein 2
NP03_GAHVM Nuclear phosphoprotein UL3 homolog
PORTL_GAHVM Portal protein
PP24_GAHVM Phosphoprotein pp24
PRIM_GAHVM DNA primase (EC 2.7.7.-)
PP38_GAHVM Phosphoprotein pp38
SCAF_GAHVM Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Virion structural ...
SCP_GAHVM Small capsomere-interacting protein
SHUT_GAHVM Virion host shutoff protein (Vhs) (EC 3.1.27.-)
TEG5_GAHVM Tegument protein UL47 homolog
TEG7_GAHVM Tegument protein UL51 homolog
TEG3_GAHVM Tegument protein UL14 homolog
TG21_GAHVM Tegument protein UL21 homolog
TRM2_GAHVM Tripartite terminase subunit 2
TEG1_GAHVM Tegument protein UL46 homolog (Tegument protein VP11/12 homolog)
TEG6_GAHVM Tegument protein UL55 homolog
HELI_GAHVM DNA replication helicase (EC 3.6.4.-)
HEPA_GAHVM DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
ICP4_GAHVM Major viral transcription factor ICP4 homolog (Immediate-early protein IE175)
ICP22_GAHVM Transcriptional regulator ICP22 homolog (Immediate early ICP22-like protein)
IL8H_GAHVM Viral interleukin-8 homolog (vIL8)
ICP27_GAHVM mRNA export factor ICP27 homolog (Transcriptional regulator IE63 homolog)
ITP_GAHVM Inner tegument protein
KITH_GAHVM Thymidine kinase (EC 2.7.1.21)
MCP_GAHVM Major capsid protein (MCP)
MB43_GAHVM Membrane protein UL43 homolog
MEQ_GAHVM Oncoprotein MEQ (MEQ)
OBP_GAHVM Replication origin-binding protein (OBP) (OriBP)
PAP_GAHVM DNA polymerase processivity factor (DNA-binding protein UL42) (Polymerase accessory protein) (PAP)
RIR2_GAHVM Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small ...
RIR1_GAHVM Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase ...
TRX1_GAHVM Triplex capsid protein 1
TRX2_GAHVM Triplex capsid protein 2
TRM1_GAHVM Tripartite terminase subunit 1
TRM3_GAHVM Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
UL32_GAHVM Packaging protein UL32 homolog
UL4_GAHVM Nuclear protein UL4 homolog
UL24_GAHVM Protein UL24 homolog
UNG_GAHVM Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
VG01_GAHVM Uncharacterized gene 1 protein
VG06B_GAHVM Uncharacterized gene 6b protein
VG71_GAHVM Uncharacterized gene 71 protein
VG72_GAHVM Uncharacterized gene 72 protein
VG83_GAHVM Uncharacterized gene 83 protein
VG85_GAHVM Uncharacterized gene 85 protein
UL13_GAHVM Serine/threonine-protein kinase UL13 homolog (EC 2.7.11.1)
US03_GAHVM Protein kinase US3 homolog (EC 2.7.11.1)
VG69_GAHVM Uncharacterized gene 69 protein
US02_GAHVM Protein US2 homolog
VG09_GAHVM Uncharacterized gene 9 protein
VG11_GAHVM Uncharacterized gene 11 protein
VLIP_GAHVM Virulence factor MDV010 (Viral lipase homolog) (vLIP)
VP16_GAHVM Tegument protein VP16 homolog (Alpha trans-inducing protein) (Alpha-TIF) (ORF10 protein) (Tegument ...
VG97_GAHVM Uncharacterized gene 97 protein
UL20_GAHVM Protein UL20 homolog
US10_GAHVM Virion protein US10 homolog
VG82_GAHVM Uncharacterized gene 82 protein
VG86_GAHVM Uncharacterized gene 86 protein
VG07_GAHVM Uncharacterized gene 7 protein
VG81_GAHVM Uncharacterized gene 81 protein
VG02_GAHVM Uncharacterized gene 2 protein
VG04_GAHVM Uncharacterized gene 4 protein
VG06A_GAHVM Uncharacterized gene 6a protein
VG90_GAHVM Uncharacterized gene 90 protein
VG12_GAHVM Uncharacterized gene 12 protein
VG87_GAHVM Uncharacterized gene 87 protein
VG93_GAHVM Uncharacterized gene 93 protein
VP22_GAHVM Tegument protein VP22

12 entries

Gallid herpesvirus 2 (strain GA) (GaHV-2) (Marek's disease herpesvirus type 1)

Select_allDeselect_all
GC_GAHVG Envelope glycoprotein C homolog (A antigen) (Glycoprotein A) (GA) (Secretory glycoprotein GP57-65)
GL_GAHVG Envelope glycoprotein L (gL)
ICP4_GAHVG Major viral transcription factor ICP4 homolog (Immediate-early protein IE175)
U1053_GAHVG Uncharacterized 40.6 kDa protein
US426_GAHVG Uncharacterized 15.7 kDa protein
US441_GAHVG Uncharacterized 16.7 kDa protein
US384_GAHVG Uncharacterized 14.2 kDa protein
US420_GAHVG Uncharacterized 15.5 kDa protein
US03_GAHVG Serine/threonine-protein kinase US3 homolog (EC 2.7.11.1)
US10_GAHVG Virion protein US10 homolog
US453_GAHVG Uncharacterized 16.6 kDa protein
VP38_GAHVG 38 kDa phosphoprotein (Phosphoprotein pp38)

4 entries

Gallid herpesvirus 2 (strain RB-1b) (GaHV-2) (Marek's disease herpesvirus type 1)

Select_allDeselect_all
GH_GAHVR Envelope glycoprotein H (gH)
GC_GAHVR Envelope glycoprotein C homolog (A antigen) (Glycoprotein A) (GA) (Secretory glycoprotein GP57-65)
GB_GAHVR Envelope glycoprotein B (gB)
KITH_GAHVR Thymidine kinase (EC 2.7.1.21)

2 entries

Gallid herpesvirus 2 (strain bc-1) (GaHV-2) (Marek's disease herpesvirus type 1)

Select_allDeselect_all
EV45_GAHVB Envelope protein UL45 homolog
GC_GAHVB Envelope glycoprotein C homolog (A antigen) (Glycoprotein A) (GA) (Secretory glycoprotein GP57-65)

2 entries

Meleagrid herpesvirus 1 (MeHV-1) (Turkey herpesvirus)

Select_allDeselect_all
GH_MEHV1 Envelope glycoprotein H (gH)
KITH_MEHV1 Thymidine kinase (EC 2.7.1.21)

2 entries

Meleagrid herpesvirus 1 (strain FC126) (MeHV-1) (Turkey herpesvirus)

Select_allDeselect_all
GC_MEHVF Envelope glycoprotein C homolog (A antigen) (Glycoprotein A)
KITH_MEHVF Thymidine kinase (EC 2.7.1.21)

2 entries

Meleagrid herpesvirus 1 (strain H2) (MeHV-1) (Turkey herpesvirus)

Select_allDeselect_all
EV45_MEHVH Envelope protein UL45 homolog (23.5 kDa protein)
GC_MEHVH Envelope glycoprotein C homolog (A antigen) (Glycoprotein A)

1 entry

Gallid herpesvirus 2 (strain MD11/75C/R2) (GaHV-2) (Marek's disease herpesvirus type 1)

VP38_GAHVN 38 kDa phosphoprotein (Phosphoprotein pp38)