Percavirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embeded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 180 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' nontranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

The viral interleukin-10 homolog down-regulates the expression of the TAP1 gene (transporter associated with antigen processing), thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.

Apoptosis modulation

The EHV-2 v-FLIP protein (ORF E8) inhibits TNFRSF1A, TNFRSF6, TNFRSF10 and TNFRSF12 induced apoptosis.

Cell-cycle modulation

The UL24 protein induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex .

Splicing inhibition

Modulates the viral and host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing.

Matching UniProtKB/Swiss-Prot entries

75 entries grouped by protein (browse by keywords)

All proteins are shown (view only 74 complete proteome entries)

1 entry

Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)

AN_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Putative transcription activator BRLF1 homolog

BRLF1_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Cytoplasmic envelopment protein 1

CEP1_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Cytoplasmic envelopment protein 2

CEP2_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Cytoplasmic envelopment protein 3

CEP3_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Viral CASP8 and FADD-like apoptosis regulator (v-CFLAR) (Viral FLICE-inhibitory protein) (v-FLIP)

CFLA_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Capsid vertex component 1

CVC1_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Capsid vertex component 2

CVC2_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Major DNA-binding protein

DNBI_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

DNA polymerase catalytic subunit (EC 2.7.7.7)

DPOL_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

DUT_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Envelope glycoprotein B (gB)

GB_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Envelope glycoprotein H (gH)

GH_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Envelope glycoprotein L (gL)

GL_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Envelope glycoprotein M (gM)

GM_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Envelope glycoprotein N

GN_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

DNA replication helicase (EC 3.6.4.-)

HELI_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)

HEPA_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Immediate-early phosphoprotein 57

IE63_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

2 entries

Viral interleukin-10 homolog (vIL-10)

Select_allDeselect_all
IL10H_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain
IL10H_EHV2T
Equine herpesvirus 2 (strain T400/3) (EHV-2)

1 entry

Inner tegument protein

ITP_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Thymidine kinase (EC 2.7.1.21)

KITH_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

LTP_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Major capsid protein (MCP)

MCP_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Nuclear egress protein 1

NEC1_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Nuclear egress protein 2

NEC2_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Portal protein

PORTL_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

DNA primase (EC 2.7.7.-)

PRIM_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase large subunit)

RIR1_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small subunit)

RIR2_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR)

SCAF_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Small capsomere-interacting protein

SCP_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Tegument protein UL51 homolog

TEG7_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Tripartite terminase subunit 1

TRM1_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Tripartite terminase subunit 2

TRM2_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)

TRM3_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Triplex capsid protein 1

TRX1_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Triplex capsid protein 2

TRX2_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)

TYSY_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Protein UL24 homolog

UL24_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Packaging protein UL32 homolog

UL32_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Uncharacterized gene 66 protein

UL49_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Gene 18 protein

UL79_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Gene 24 protein

UL87_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Uncharacterized gene 30 protein

UL91_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Gene 31 protein

UL92_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Gene 34 protein

UL95_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Gene 35 protein

UL96_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)

UNG_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

CARD domain-containing protein E10

VCLAP_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Uncharacterized gene 10 protein

VG10_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Uncharacterized gene 11 protein

VG11_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Protein E6A

VG12_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Protein E6C

VG13_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Uncharacterized gene 23 protein

VG23_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Uncharacterized gene 27 protein

VG27_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Uncharacterized gene 28 protein

VG28_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Probable inactive protein kinase 38

VG36_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Uncharacterized gene 45 protein

VG45_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Tegument protein G48

VG48_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Uncharacterized gene 49 protein

VG49_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Putative C-type lectin protein 51

VG51_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Gene 52 protein

VG52_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Gene 58 protein

VG58_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

DNA polymerase processivity factor

VG59_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

G-protein coupled receptor 74

VG74_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Probable membrane antigen 75 (Tegument protein)

VG75_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

G-protein coupled receptor E1

VGE1_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Uncharacterized gene E2 protein

VGE2_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

SUSHI domain-containing protein E3

VGE3_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Uncharacterized gene E4 protein

VGE4_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

G-protein coupled receptor E6

VGE6_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Uncharacterized gene E9 protein

VGE9_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

1 entry

Probable membrane antigen 3 (Tegument protein)

VP03_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain