Alloherpesviridae

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers. Glycoproteins complexes are embed in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of 134-248 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' non-translated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Entry into host cell is still unclear and may depend on the host cell type, i.e. endocytosis versus fusion at the plasma membrane.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes.
  5. Transcription of early viral mRNA by host polymerase II, transport into the cytoplasm and translation into early proteins.
  6. Early proteins are involved in replication of the viral DNA and are transported back into the nucleus.
  7. Synthesis of multiple copies of viral DNA by the viral DNA-dependent DNA polymerase.
  8. Transcription of late mRNAs by host polymerase II, transport into the cytoplasm and translation into late proteins.
  9. Late proteins are structural or core proteins and are transported back into the nucleus.
  10. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Matching UniProtKB/Swiss-Prot entries

76 entries grouped by strain (browse by keywords)

76 entries

Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) reference strain

Select_allDeselect_all
DPOL_ICHVA DNA polymerase (EC 2.7.7.7)
DUT_ICHVA Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
HELI_ICHVA Probable ATP-dependent helicase 25 (EC 3.6.4.-)
KR14_ICHVA Protein kinase ORF14 (EC 2.7.11.1)
KR16_ICHVA Protein kinase ORF16 (EC 2.7.11.1)
KR15_ICHVA Protein kinase ORF15 (EC 2.7.11.1)
VG28_ICHVA Uncharacterized protein ORF28
VG38_ICHVA Uncharacterized protein ORF38
VG41_ICHVA Uncharacterized protein ORF41
VG46_ICHVA Probable major glycoprotein
VG04_ICHVA Uncharacterized protein ORF4
VG60_ICHVA Uncharacterized protein ORF60
VTER_ICHVA Probable DNA-packaging protein (Terminase)
VG02_ICHVA Uncharacterized protein ORF2
VG09_ICHVA Putative zinc-binding protein ORF9
VG12_ICHVA Putative zinc-binding protein ORF12
VG29_ICHVA Uncharacterized protein ORF29
VG44_ICHVA Uncharacterized protein ORF44
VG45_ICHVA Uncharacterized protein ORF45
VG54_ICHVA Uncharacterized protein ORF54
VG56_ICHVA Uncharacterized protein ORF56
VG03_ICHVA Uncharacterized protein ORF3
VG07_ICHVA Putative membrane protein ORF7
VG11_ICHVA Putative zinc-binding protein ORF11
VG34_ICHVA Uncharacterized protein ORF34
VG35_ICHVA Uncharacterized protein ORF35
VG43_ICHVA Uncharacterized protein ORF43
VG48_ICHVA Uncharacterized protein ORF48
VG61_ICHVA Uncharacterized protein ORF61
VG63_ICHVA Uncharacterized protein ORF63
VG68_ICHVA Uncharacterized protein ORF68
VG22_ICHVA Uncharacterized protein ORF22
VG26_ICHVA Uncharacterized protein ORF26
VG27_ICHVA Uncharacterized protein ORF27
VG40_ICHVA Uncharacterized protein ORF40
VG42_ICHVA Uncharacterized protein ORF42
VG64_ICHVA Uncharacterized protein ORF64
VG75_ICHVA Uncharacterized protein ORF75
VG39_ICHVA Uncharacterized protein ORF39
VG50_ICHVA Uncharacterized protein ORF50
VG51_ICHVA Putative membrane protein ORF51
VG77_ICHVA Uncharacterized protein ORF77
VG72_ICHVA Uncharacterized protein ORF72
VG78_ICHVA Putative zinc-binding protein ORF78
KR73_ICHVA Protein kinase ORF73 (EC 2.7.11.1)
KITH_ICHVA Thymidine kinase (EC 2.7.1.21)
KR74_ICHVA Protein kinase ORF74 (EC 2.7.11.1)
VG17_ICHVA Uncharacterized protein ORF17
VG19_ICHVA Putative membrane protein ORF19
VG47_ICHVA Subtilisin-like protease (EC 3.4.21.-)
VG52_ICHVA Uncharacterized protein ORF52
VG01_ICHVA Uncharacterized protein ORF1
VG08_ICHVA Putative membrane protein ORF8
VG21_ICHVA Uncharacterized protein ORF21
VG23_ICHVA Uncharacterized protein ORF23
VG31_ICHVA Uncharacterized protein ORF31
VG70_ICHVA Uncharacterized protein ORF70
VG76_ICHVA Uncharacterized protein ORF76
VG79_ICHVA Uncharacterized protein ORF79
VG06_ICHVA Putative membrane protein ORF6
VG10_ICHVA Putative membrane protein ORF10
VG13_ICHVA Uncharacterized protein ORF13
VG18_ICHVA Uncharacterized protein ORF18
VG20_ICHVA Uncharacterized protein ORF20
VG24_ICHVA Uncharacterized protein ORF24
VG33_ICHVA Uncharacterized protein ORF33
VG37_ICHVA Uncharacterized protein ORF37
VG53_ICHVA Uncharacterized protein ORF53
VG55_ICHVA Uncharacterized protein ORF55
VG30_ICHVA Uncharacterized protein ORF30
VG32_ICHVA Uncharacterized protein ORF32
VG36_ICHVA Uncharacterized protein ORF36
VG59_ICHVA Putative membrane protein ORF59
VG65_ICHVA Uncharacterized protein ORF65
VG66_ICHVA Uncharacterized protein ORF66
VG67_ICHVA Uncharacterized protein ORF67