Malacoherpesviridae

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers. Glycoproteins complexes are embeded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of 134 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' nontranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Entry into host cell is still unclear and may depend on the host cell type, i.e. endocytosis versus fusion at the plasma membrane.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes.
  5. Transcription of early viral mRNA by host polymerase II, transport into the cytoplasm and translation into early proteins.
  6. Early proteins are involved in replication of the viral DNA and are transported back into the nucleus.
  7. Synthesis of multiple copies of viral DNA by the viral DNA-dependent DNA polymerase.
  8. Transcription of late mRNAs by host polymerase II, transport into the cytoplasm and translation into late proteins.
  9. Late proteins are structural or core proteins and are transported back into the nucleus.
  10. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Matching UniProtKB/Swiss-Prot entries

114 entries grouped by strain (browse by keywords)

114 entries

Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) reference strain

Select_allDeselect_all
DPOL_OSHVF DNA polymerase (EC 2.7.7.7)
IAP3_OSHVF Putative apoptosis inhibitor ORF99
IAP4_OSHVF Putative apoptosis inhibitor ORF106
IAP1_OSHVF Putative apoptosis inhibitor ORF42
IAP2_OSHVF Putative apoptosis inhibitor ORF87
PRIM_OSHVF Putative primase (EC 2.7.7.-)
Y001_OSHVF Uncharacterized protein ORF1
Y028_OSHVF Uncharacterized protein ORF28
Y029_OSHVF Uncharacterized protein ORF29
Y044_OSHVF Uncharacterized protein ORF44
Y069_OSHVF Uncharacterized protein ORF69
Y091_OSHVF Uncharacterized protein ORF91
Y092_OSHVF Uncharacterized protein ORF92
Y093_OSHVF Uncharacterized protein ORF93
Y104_OSHVF Uncharacterized protein ORF104
Y109_OSHVF Uncharacterized protein ORF109
Y112_OSHVF Uncharacterized protein ORF112
Y113_OSHVF Uncharacterized protein ORF113
Y006_OSHVF Uncharacterized protein ORF6
Y015_OSHVF Uncharacterized protein ORF15
Y021_OSHVF Uncharacterized protein ORF21
Y070_OSHVF Uncharacterized protein ORF70
Y079_OSHVF Uncharacterized protein ORF79
Y012_OSHVF Uncharacterized protein ORF12
Y024_OSHVF Uncharacterized protein ORF24
Y048_OSHVF Uncharacterized protein ORF48
Y054_OSHVF Uncharacterized protein ORF54
Y060_OSHVF Uncharacterized protein ORF60
Y085_OSHVF Uncharacterized protein ORF85
Y098_OSHVF Uncharacterized protein ORF98
Y103_OSHVF Putative transmembrane protein ORF103
Y004_OSHVF Uncharacterized protein ORF4
Y027_OSHVF Uncharacterized protein ORF27
Y102_OSHVF Uncharacterized protein ORF102
Y110_OSHVF Uncharacterized protein ORF110
Y076_OSHVF Uncharacterized protein ORF76
Y089_OSHVF Uncharacterized protein ORF89
Y096_OSHVF Putative RING finger protein ORF96
Y097_OSHVF Putative RING finger protein ORF97
Y033_OSHVF Uncharacterized protein ORF33
Y037_OSHVF Uncharacterized protein ORF37
Y047_OSHVF Uncharacterized protein ORF47
Y057_OSHVF Putative transmembrane protein ORF57
Y064_OSHVF Uncharacterized protein ORF64
Y067_OSHVF Uncharacterized protein ORF67
Y080_OSHVF Uncharacterized protein ORF80
Y094_OSHVF Uncharacterized protein ORF94
Y116_OSHVF Uncharacterized protein ORF116
Y122_OSHVF Uncharacterized protein ORF122
Y123_OSHVF Uncharacterized protein ORF123
Y014_OSHVF Uncharacterized protein ORF14
Y022_OSHVF Uncharacterized protein ORF22
Y025_OSHVF Putative transmembrane protein ORF25
Y045_OSHVF Uncharacterized protein ORF45
Y019_OSHVF Uncharacterized protein ORF19
Y013_OSHVF Uncharacterized protein ORF13
Y031_OSHVF Uncharacterized protein ORF31
Y035_OSHVF Uncharacterized protein ORF35
Y038_OSHVF Putative RING finger protein ORF38
Y039_OSHVF Uncharacterized protein ORF39
Y040_OSHVF Uncharacterized protein ORF40
Y049_OSHVF Uncharacterized protein ORF49
Y052_OSHVF Uncharacterized protein ORF52
Y072_OSHVF Uncharacterized protein ORF72
Y078_OSHVF Uncharacterized protein ORF78
Y081_OSHVF Uncharacterized protein ORF81
Y083_OSHVF Uncharacterized protein ORF83
Y095_OSHVF Uncharacterized protein ORF95
Y108_OSHVF Uncharacterized protein ORF108
Y034_OSHVF Uncharacterized protein ORF34
Y036_OSHVF Uncharacterized protein ORF36
Y056_OSHVF Uncharacterized protein ORF56
Y068_OSHVF Putative transmembrane protein ORF68
Y074_OSHVF Uncharacterized protein ORF74
Y075_OSHVF Uncharacterized protein ORF75
Y077_OSHVF Uncharacterized protein ORF77
Y124_OSHVF Uncharacterized protein ORF124
Y008_OSHVF Uncharacterized protein ORF8
Y009_OSHVF Putative RING finger protein ORF9
Y053_OSHVF Uncharacterized protein ORF53
Y055_OSHVF Uncharacterized protein ORF55
Y088_OSHVF Putative transmembrane protein ORF88
Y101_OSHVF Uncharacterized protein ORF101
Y114_OSHVF Uncharacterized protein ORF114
Y118_OSHVF Putative RING finger protein ORF118
Y003_OSHVF Uncharacterized protein ORF3
Y041_OSHVF Uncharacterized protein ORF41
Y043_OSHVF Uncharacterized protein ORF43
Y046_OSHVF Uncharacterized protein ORF46
Y058_OSHVF Uncharacterized protein ORF58
Y059_OSHVF Uncharacterized protein ORF59
Y061_OSHVF Uncharacterized protein ORF61
Y082_OSHVF Uncharacterized protein ORF82
Y090_OSHVF Uncharacterized protein ORF90
Y002_OSHVF Uncharacterized protein ORF2
Y016_OSHVF Uncharacterized protein ORF16
Y017_OSHVF Uncharacterized protein ORF17
Y018_OSHVF Uncharacterized protein ORF18
Y023_OSHVF Uncharacterized protein ORF23
Y117_OSHVF Putative RING finger protein ORF117
Y121_OSHVF Putative zinc finger protein ORF121
Y010_OSHVF Uncharacterized protein ORF10
Y026_OSHVF Uncharacterized protein ORF26
Y030_OSHVF Uncharacterized protein ORF30
Y071_OSHVF Uncharacterized protein ORF71
Y084_OSHVF Uncharacterized protein ORF84
Y086_OSHVF Uncharacterized protein ORF86
Y107_OSHVF Uncharacterized protein ORF107
Y111_OSHVF Putative transmembrane protein ORF111
Y115_OSHVF Uncharacterized protein ORF115
Y119_OSHVF Uncharacterized protein ORF119
Y120_OSHVF Uncharacterized protein ORF120
RIR1_OSHVF Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1)
RIR2_OSHVF Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1)