Tymoviridae

VIRION

Non-enveloped, isometric capsid with T=3 icosahedral symmetry, about 30 nm in diameter.

GENOME

Monopartite, linear, C-rich, ssRNA(+) genome of 6-7.5 kb. The 3'-terminus may have a tRNA-like structure or a polyA tract, depending upon the virus.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. The virion RNA is infectious and serves as both the genome and viral messenger RNA. The ORF1 encodes a polyprotein whichis expressed by leaky scanning. The capsid protein is translated from a subgenomic RNA.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA is translated to produce the protein necessary for RNA synthesis (replication and transcription).
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. The RdRp recognizes an internal subgenomic promoter on the negative-sense RNA to transcribe the 3’co-terminal subgenomic RNA that will generate the capsid protein.
  7. Assembly of new virus particles.

Host-virus interaction

Modulation of host ubiquitin pathway by virus

Turnip yellow mosaic virus 98K replication protein counteracts degradation of its RNA-dependent RNA polymerase (RdRp) by the host ubiquitin-proteasome system. The viral 98K replication protein mediates deubiquitylation of RdRp leading to its stabilization .

Matching UniProtKB/Swiss-Prot entries

28 entries grouped by protein (browse by keywords)

All proteins are shown (view only 18 complete proteome entries)

1 entry

Capsid protein (CP) (Coat protein)

CAPSD_GFKVM
Grapevine fleck virus (isolate Italy/MT48) (GFkV) reference strain

9 entries

Coat protein (Virion protein)

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COAT_TYMV
Turnip yellow mosaic virus reference strain
COAT_BMDV
Belladonna mottle virus (BMDV)
COAT_CAYMV
Cacao yellow mosaic virus
COAT_ELV
Erysimum latent virus (ELV)
COAT_EPMV
Eggplant mosaic virus
COAT_KYMVJ
Kennedya yellow mosaic virus (strain Jervis bay) (KYMV)
COAT_OYMV
Ononis yellow mosaic virus
COAT_PHMV
Physalis mottle virus (PhMV) (Belladonna mottle virus-Iowa)
COAT_TYMVA
Turnip yellow mosaic virus (isolate Australia)

1 entry

Putative movement protein

MOVP_MRFVC
Maize rayado fino virus (isolate Costa Rica/Guapiles) (MRFV) reference strain

1 entry

Uncharacterized protein ORF3

ORF3_GFKVM
Grapevine fleck virus (isolate Italy/MT48) (GFkV) reference strain

1 entry

Uncharacterized protein ORF4

ORF4_GFKVM
Grapevine fleck virus (isolate Italy/MT48) (GFkV) reference strain

5 entries

69 kDa protein (p69)

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P69_TYMV
Turnip yellow mosaic virus reference strain
P69_EPMV
Eggplant mosaic virus

70 kDa protein

P69_OYMV
Ononis yellow mosaic virus

66 kDa protein

P69_TYMVA
Turnip yellow mosaic virus (isolate Australia)
P69_TYMVC
Turnip yellow mosaic virus (isolate TYMC)

1 entry

Genome polyprotein

POLG_MRFVC
Maize rayado fino virus (isolate Costa Rica/Guapiles) (MRFV) reference strain

7 entries

RNA replicase polyprotein (EC 2.7.7.48)

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POLR_TYMV
Turnip yellow mosaic virus reference strain

RNA replicase polyprotein (206 kDa polyprotein)

POLR_ELV
Erysimum latent virus (ELV)
POLR_EPMV
Eggplant mosaic virus
POLR_KYMVJ
Kennedya yellow mosaic virus (strain Jervis bay) (KYMV)
POLR_OYMV
Ononis yellow mosaic virus
POLR_TYMVA
Turnip yellow mosaic virus (isolate Australia)
POLR_TYMVC
Turnip yellow mosaic virus (isolate TYMC)

1 entry

RNA replication protein

RDRP_GFKVM
Grapevine fleck virus (isolate Italy/MT48) (GFkV) reference strain

1 entry

Uncharacterized 48 kDa protein

Y48K_ELV
Erysimum latent virus (ELV)