Xipapillomavirus

VIRION

Non-enveloped. Small, icosahedral, about 52-55 nm in size. A single molecule of circular dsDNA is contained within the T=7 icosahedral capsid, which is composed of 72 pentamers.

GENOME

Circular dsDNA, about 7 kb in size, associated with cellular histones. A characteristic E6 ORF is absent.
On rare non-specific recombination, the viral genome can be integrated in host chromosome. This inactivates the integrated virus but can gives the host cell a replicative advantage sometimes leading to malignant tumours.

GENE EXPRESSION

Only one strand of the genome is transcribed and yield two classes of proteins expressed by alternative splicing: a) Early Proteins: non-structural regulatory proteins (E1-E7).
b) Late Proteins: the structural proteins L1 and L2.

REPLICATION

NUCLEAR

Replication is divided in two distinct steps that are linked to the differentiation state of the host epithelial cell:

a) The plasmid replication takes place in the basal squamous epithelial cells. It corresponds to viral DNA replication in synchrony with the host cell chromosome in order to ensures an average of one viral genome per basal cell.

  1. Attachment of the viral proteins to host receptors mediates endocytosis into vesicles in the basal squamous epithelial cell.
  2. Transport to the nucleus and uncoating of the viral DNA.
  3. Early-region transcription and translation of the early proteins.
  4. Steady-state viral DNA nuclear replication. Requires the origin of DNA replication in cis and the viral E1 and E2 proteins in trans.

b) The vegetative replication, which occurs in differentiated keratinocytes. In these cells, which no longer undergo cellular DNA synthesis, there is a burst of viral DNA synthesis with active production of virions.

  1. Vegetative viral DNA synthesis.
  2. Transcription of the late region.
  3. Capsid proteins L1 and L2 synthesis.
  4. Nuclear capsid assembly and release of viruses.

Matching UniProtKB/Swiss-Prot entries

22 entries grouped by protein (browse by keywords)

3 entries

Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)

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VE1_BPV3
Bovine papillomavirus type 3 reference strain
VE1_BPV4
Bovine papillomavirus type 4 reference strain
VE1_BPV6
Bovine papillomavirus type 6

3 entries

Regulatory protein E2

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VE2_BPV3
Bovine papillomavirus type 3 reference strain
VE2_BPV4
Bovine papillomavirus type 4 reference strain
VE2_BPV6
Bovine papillomavirus type 6

1 entry

Probable protein E3

VE3_BPV4
Bovine papillomavirus type 4 reference strain

1 entry

Probable protein E4

VE4_BPV4
Bovine papillomavirus type 4 reference strain

1 entry

Probable protein E5A

VE5A_BPV4
Bovine papillomavirus type 4 reference strain

1 entry

Probable protein E5B

VE5B_BPV4
Bovine papillomavirus type 4 reference strain

3 entries

Protein E7

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VE7_BPV3
Bovine papillomavirus type 3 reference strain
VE7_BPV4
Bovine papillomavirus type 4 reference strain
VE7_BPV6
Bovine papillomavirus type 6

3 entries

Uncharacterized protein E8

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VE8_BPV3
Bovine papillomavirus type 3 reference strain
VE8_BPV4
Bovine papillomavirus type 4 reference strain
VE8_BPV6
Bovine papillomavirus type 6

1 entry

Protein E8^E2C

VE8E2_BPV3
Bovine papillomavirus type 3 reference strain

2 entries

Major capsid protein L1

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VL1_BPV3
Bovine papillomavirus type 3 reference strain
VL1_BPV4
Bovine papillomavirus type 4 reference strain

2 entries

Minor capsid protein L2

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VL2_BPV3
Bovine papillomavirus type 3 reference strain
VL2_BPV4
Bovine papillomavirus type 4 reference strain

1 entry

Probable protein L3

VL3_BPV4
Bovine papillomavirus type 4 reference strain