Paramyxoviridae

VIRION

Enveloped, spherical. Diameter of about 150 nm.

GENOME

Negative-stranded RNA linear genome, about 15 kb in size. Encodes for eight proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. Most express a C protein by leaky scanning and V/W proteins by mRNA editing.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through HN, H or G glycoproteins.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthesized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of MDA-5 antiviral signaling

The Nipah P,V and W proteins play a role in inhibition of STAT1 antiviral signaling

The Sendai C protein plays a role in inhibition of STAT1 antiviral signaling

Matching UniProtKB/Swiss-Prot entries

136 entries grouped by protein (browse by keywords)

Only complete proteome entries are shown (view all 316 entries)

11 entries

Protein C

Select_allDeselect_all
C_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
C_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
C_PI3B
Bovine parainfluenza 3 virus (BPIV-3) reference strain
C_SENDO
Sendai virus (strain Ohita) (SeV) reference strain

Protein C'

C_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain

C' protein

C_TPMV
Tupaia paramyxovirus (TPMV) reference strain
C_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
C_NIPAV
Nipah virus
C_RINDR
Rinderpest virus (strain RBOK) (RDV)
C_SENDA
Sendai virus (strain Hamamatsu) (SeV)

Protein C'

C_SENDF
Sendai virus (strain Fushimi) (SeV)

Protein C'

16 entries

Fusion glycoprotein F0

Select_allDeselect_all
FUS_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain

Fusion glycoprotein F0 (Protein F)

FUS_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
FUS_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain
FUS_NDVB1
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
FUS_PI2HT
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
FUS_PI3B
Bovine parainfluenza 3 virus (BPIV-3) reference strain
FUS_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
FUS_SENDO
Sendai virus (strain Ohita) (SeV) reference strain

Fusion glycoprotein F0 (Protein F)

FUS_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain

Fusion glycoprotein F0 (Protein F)

FUS_SV41
Simian virus 41 (SV41) reference strain
FUS_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
FUS_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
FUS_NIPAV
Nipah virus

Fusion glycoprotein F0 (Protein F)

FUS_RINDR
Rinderpest virus (strain RBOK) (RDV)
FUS_SENDA
Sendai virus (strain Hamamatsu) (SeV)

Fusion glycoprotein F0 (Protein F)

FUS_SENDF
Sendai virus (strain Fushimi) (SeV)

Fusion glycoprotein F0 (Protein F)

2 entries

Glycoprotein G

Select_allDeselect_all
GLYCP_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
GLYCP_NIPAV
Nipah virus

4 entries

Hemagglutinin glycoprotein

Select_allDeselect_all
HEMA_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
HEMA_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
HEMA_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
HEMA_RINDR
Rinderpest virus (strain RBOK) (RDV)

10 entries

Hemagglutinin-neuraminidase (EC 3.2.1.18)

Select_allDeselect_all
HN_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain
HN_NDVB1
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
HN_PI2HT
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
HN_PI3B
Bovine parainfluenza 3 virus (BPIV-3) reference strain
HN_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
HN_SENDO
Sendai virus (strain Ohita) (SeV) reference strain

Hemagglutinin-neuraminidase (HN protein) (Protein HANA) (EC 3.2.1.18)

HN_SV41
Simian virus 41 (SV41) reference strain
HN_SENDA
Sendai virus (strain Hamamatsu) (SeV)

Hemagglutinin-neuraminidase (HN protein) (EC 3.2.1.18)

HN_SENDF
Sendai virus (strain Fushimi) (SeV)

Hemagglutinin-neuraminidase (HN protein) (EC 3.2.1.18)

HN_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ))

Hemagglutinin-neuraminidase (HN protein) (EC 3.2.1.18)

16 entries

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

Select_allDeselect_all
L_CDVO
Canine distemper virus (strain Onderstepoort) (CDV) reference strain
L_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
L_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
L_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain
L_NDVB1
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
L_PI2HT
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
L_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
L_SENDO
Sendai virus (strain Ohita) (SeV) reference strain
L_SV41
Simian virus 41 (SV41) reference strain
L_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
L_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
L_NIPAV
Nipah virus
L_RINDR
Rinderpest virus (strain RBOK) (RDV)
L_SENDA
Sendai virus (strain Hamamatsu) (SeV)
L_SENDF
Sendai virus (strain Fushimi) (SeV)
L_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ))

16 entries

Matrix protein

Select_allDeselect_all
MATRX_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain

Matrix protein (Protein M)

MATRX_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
MATRX_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain
MATRX_NDVB1
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
MATRX_PI2HT
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain

Matrix protein (Membrane protein)

MATRX_PI3B
Bovine parainfluenza 3 virus (BPIV-3) reference strain
MATRX_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain

Matrix protein (Membrane protein)

MATRX_SENDO
Sendai virus (strain Ohita) (SeV) reference strain

Matrix protein (M protein)

MATRX_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain

Matrix protein (M protein)

MATRX_SV41
Simian virus 41 (SV41) reference strain
MATRX_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
MATRX_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
MATRX_NIPAV
Nipah virus

Matrix protein (Protein M)

MATRX_RINDR
Rinderpest virus (strain RBOK) (RDV)
MATRX_SENDA
Sendai virus (strain Hamamatsu) (SeV)

Matrix protein (M protein)

MATRX_SENDF
Sendai virus (strain Fushimi) (SeV)

Matrix protein (M protein)

22 entries

Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

Select_allDeselect_all
NCAP_CDVO
Canine distemper virus (strain Onderstepoort) (CDV) reference strain

Nucleoprotein (Protein N) (Nucleocapsid protein)

NCAP_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain

Nucleoprotein (Protein N) (Nucleocapsid protein)

NCAP_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
NCAP_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain
NCAP_NDVB1
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
NCAP_PI2HT
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
NCAP_PI3B
Bovine parainfluenza 3 virus (BPIV-3) reference strain
NCAP_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
NCAP_SENDO
Sendai virus (strain Ohita) (SeV) reference strain
NCAP_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain
NCAP_SV41
Simian virus 41 (SV41) reference strain
NCAP_TPMV
Tupaia paramyxovirus (TPMV) reference strain
NCAP_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
NCAP_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
NCAP_MEASM
Measles virus (strain Edmonston-Moraten vaccine) (MeV) (Subacute sclerose panencephalitis virus)
NCAP_MEASW
Measles virus (strain Edmonston-Schwarz vaccine) (MeV) (Subacute sclerose panencephalitis virus)
NCAP_MUMPJ
Mumps virus (strain Jeryl-Lynn) (MuV)
NCAP_NIPAV
Nipah virus

Nucleoprotein (Protein N) (Nucleocapsid protein)

NCAP_PPRV
Peste-des-petits-ruminants virus (PPRV)
NCAP_RINDR
Rinderpest virus (strain RBOK) (RDV)
NCAP_SENDA
Sendai virus (strain Hamamatsu) (SeV)
NCAP_SENDF
Sendai virus (strain Fushimi) (SeV)

15 entries

Phosphoprotein (Protein P)

Select_allDeselect_all
PHOSP_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
PHOSP_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
PHOSP_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain
PHOSP_NDVB1
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
PHOSP_PI2HT
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
PHOSP_PI3B
Bovine parainfluenza 3 virus (BPIV-3) reference strain
PHOSP_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
PHOSP_SENDO
Sendai virus (strain Ohita) (SeV) reference strain
PHOSP_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain
PHOSP_TPMV
Tupaia paramyxovirus (TPMV) reference strain
PHOSP_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
PHOSP_NIPAV
Nipah virus
PHOSP_RINDR
Rinderpest virus (strain RBOK) (RDV)
PHOSP_SENDA
Sendai virus (strain Hamamatsu) (SeV)
PHOSP_SENDF
Sendai virus (strain Fushimi) (SeV)

2 entries

Small hydrophobic protein

Select_allDeselect_all
SH_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain
SH_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain

15 entries

Non-structural protein V

Select_allDeselect_all
V_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
V_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
V_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain

Non-structural protein V (Non-structural protein NS1)

V_NDVB1
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain

Protein V

V_PI2HT
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
V_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
V_SENDO
Sendai virus (strain Ohita) (SeV) reference strain

Protein V

V_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain

Protein V

V_SV41
Simian virus 41 (SV41) reference strain
V_TPMV
Tupaia paramyxovirus (TPMV) reference strain
V_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
V_NIPAV
Nipah virus
V_SENDA
Sendai virus (strain Hamamatsu) (SeV)

Protein V

V_SENDF
Sendai virus (strain Fushimi) (SeV)

Protein V

7 entries

Protein W

Select_allDeselect_all
W_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
W_NDVB1
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
W_SENDO
Sendai virus (strain Ohita) (SeV) reference strain
W_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain
W_NIPAV
Nipah virus
W_SENDA
Sendai virus (strain Hamamatsu) (SeV)
W_SENDF
Sendai virus (strain Fushimi) (SeV)