Herpesviruses tegument proteins

Conservation HHV-1 PRV Varicella HCMV HHV6 EBV KSHV Function
All UL7 UL7 ORF53 UL103 U75 BBRF2 ORF42 Secondary envelopment
AllUL11UL11ORF49UL99U71BBLF1ORF38Secondary envelopment
AllUL13UL13ORF47UL97U69BGLF4 ORF36 Multifunctional kinase
AllUL16UL16ORF44UL94U65BGLF2ORF33Secondary envelopment
AllUL36UL36ORF22UL48U31BPLF1ORF64Secondary envelopment/trafficking
AllUL37UL37ORF21UL47U30BOLF1ORF63Secondary envelopment/trafficking
AllUL51UL51ORF7UL71U44BSRF1ORF55Second envelopment
AlphaUL50UL50ORF8UL72U45xxdUTPase
AlphaUL23UL23ORF36xxBXLF1ORF21Thymidine kinase
AlphaUS2US2xxxxx-
AlphaUS3US3ORF66xxxxInhibition of IRF3
AlphaICP34.5ICP34.5xxxxxPrevents EIF2A/PKR
AlphaUS10US10xxxxx-
AlphaUS11US11xxxxxInhibition of host innate immune response by virus
AlphaICP0ICP0IE61xxxxPML modification
AlphaRS1RS1ORF62/71xxxxTranscription modulation
AlphaUL14UL14ORF46xxxxNuclear import of capsids and VP16
AlphaUL21UL21ORF38xxxxDNA packaging/capsid maturation events
AlphaVHSVHSORF17xxxxtranslation initiation inhibitor
AlphaUL46ORF12ORF12xxxx Activation of the host PI3K/AKT
AlphaUL47UL47ORF11xxxxModulates VHS and virion nuclear egress
AlphaVP16VP16ORF10xxxxTranscription IE genes
AlphaVP22 (UL49)VP22 (UL49)ORF9xxxxModulates VHS and chromatin
AlphaUL55UL55ORF3xxxx-
BetaxxxUL24U3xx-
BetaxxxUL25 (pp85)U14xx-
BetaxxxUL26xxxTransactivator of viral promoters
BetaxxxUL32(pp150)U11xxViral maturation and release
BetaxxxUL35xxxTranscription IE genes/remodel PML bodies
BetaxxxUL43U25xx-
BetaxxxUL45U28xxRibonucleoside-diphosphate reductase
BetaICP27ICP27ORF4UL69U42BMLF1ORF57-
BetaxxxUL82(pp71)U54xxCounteracts DAXX
BetaxxxUL83(pp65)U54xxInhibition IRF3
BetaxxxUL88U59xx-
BetaxxxUL93U64xx-
BetaxxxIRS1xxxPKR inhibition
BetaxxxTSR1-xxPKR inhibition/Autophagy modulation
BetaxxxUS22DR7xx-
GammaxxxxxBNRF1ORF75Inhibition of DAXX/PML
GammaxxxxxBLRF2ORF52Viral maturation and release
GammaxxxxxBRRF2x-
GammaxxxxxBKRF4ORF45IRF7 inhibition


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