Ranavirus

VIRION

Polyhedral virions 120-350 nm in diameter. The capsid displays an icosahedral symmetry T=133 or 147, with an internal lipid membrane. Virions are either externally enveloped or not depending whether they budded from the cell membrane, or were arranged in paracrystaline array in the host cell cytoplasm and were released by lysis.

GENOME

Linear, dsDNA genome of 150-170 kb. The genome contains terminal and redundant sequences. Encodes for about 100 proteins.
Approximately 25% of the cytosine residues of the genome are methylated by a virus encoded DNA methyltransferase. However, there is at least one ranavirus, Singapore grouper iridovirus (SGIV), that lacks the DNA methyltransferase gene and cannot methylate its DNA.

GENE EXPRESSION

REPLICATION

NUCLEO-CYTOPLASMIC

  1. Attachement of the viral proteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the DNA core into the host cytoplasm.
  3. Viral DNA is transported to the cell nucleus where host macromolecular synthesis is rapidly shutdown. Transcription is initiated by virally modified host RNA polymerase II.
  4. Parental DNA is used to produce genome and greater than genome length DNA.
  5. Progeny DNA is transported into cytoplasmic viral factories where large concatamers of viral DNA are formed by recombination. Transcription of very late transcripts may also take place in the cytoplasm.
  6. Assembly of new virions in the cytoplasm.
  7. Virions exit the cell by budding or cell lysis.

Host-virus interaction

Apoptosis modulation

The grouper iridovirus (GIV) contains an antiapoptotic B-cell lymphoma (Bcl)-2-like gene that inhibits host apoptosis.

Matching UniProtKB/Swiss-Prot entries

99 entries grouped by strain (browse by keywords)

All proteins are shown (view only 98 complete proteome entries)

98 entries

Frog virus 3 (isolate Goorha) (FV-3) reference strain

Select_allDeselect_all
VINT_FRG3G Integrase homolog
VP31_FRG3G Early 31 kDa protein (P31K)
001R_FRG3G Putative transcription factor 001R
003R_FRG3G Uncharacterized protein 3R
011R_FRG3G Uncharacterized protein 011R
012L_FRG3G Uncharacterized protein 012L
018L_FRG3G Uncharacterized protein 018L
019R_FRG3G Putative serine/threonine-protein kinase 019R (EC 2.7.11.1)
023R_FRG3G Uncharacterized protein 023R
024R_FRG3G Uncharacterized protein 024R
028R_FRG3G Uncharacterized protein 028R
036L_FRG3G Uncharacterized protein 036L
037R_FRG3G uncharacterized protein 037R
043R_FRG3G Uncharacterized protein 043R
044R_FRG3G Uncharacterized protein 044R
045L_FRG3G Uncharacterized protein 045L
050L_FRG3G Uncharacterized protein 050L
051R_FRG3G Uncharacterized protein 051R
054L_FRG3G Uncharacterized protein 054L
055L_FRG3G Putative helicase 055L (EC 3.6.4.-)
057R_FRG3G Putative phosphotransferase 057R
058R_FRG3G Uncharacterized protein 058R
065L_FRG3G Putative collagen-like domain-containing protein 065L
068R_FRG3G Putative uncharacterized protein 068R
069R_FRG3G Transmembrane protein 069R
077L_FRG3G LCDV1 orf2-like protein
078L_FRG3G Uncharacterized protein 078L
098R_FRG3G Uncharacterized protein 098R
010R_FRG3G Uncharacterized protein 010R
020R_FRG3G Uncharacterized protein 020R
029L_FRG3G Uncharacterized protein 029L
031R_FRG3G Uncharacterized protein 031R
030R_FRG3G Uncharacterized protein 030R
032R_FRG3G Uncharacterized protein 032R
034R_FRG3G Uncharacterized protein 034R
035L_FRG3G Uncharacterized protein 035L
046L_FRG3G Uncharacterized protein 046L
049L_FRG3G Putative SAP domain-containing protein 049L
052L_FRG3G Uncharacterized protein 052L
064R_FRG3G Caspase recruitment domain-containing protein 064R
066L_FRG3G Uncharacterized protein 066L
071R_FRG3G Uncharacterized protein 071R
073L_FRG3G Uncharacterized protein 073L
074L_FRG3G Uncharacterized protein 074L
075L_FRG3G Uncharacterized protein 075L
079R_FRG3G Uncharacterized protein 079R
086L_FRG3G Uncharacterized protein 086L
095R_FRG3G Putative RAD2-like endonuclease 095R (EC 3.1.-.-)
005R_FRG3G Uncharacterized protein 005R
033R_FRG3G Transmembrane protein 033R
039R_FRG3G Uncharacterized protein 039R
040R_FRG3G Uncharacterized protein 040R
041R_FRG3G Uncharacterized protein 041R
042L_FRG3G Uncharacterized protein 042L
047L_FRG3G Uncharacterized protein 047L
076R_FRG3G Uncharacterized protein 076R
081R_FRG3G Putative transcription elongation factor S-II-like protein 81R
089R_FRG3G Uncharacterized protein 89R
092R_FRG3G Uncharacterized protein 092R
007R_FRG3G Uncharacterized protein 007R
014R_FRG3G Uncharacterized protein 014R
009L_FRG3G Putative helicase 009L (EC 3.6.4.-)
021L_FRG3G Uncharacterized protein 021L
027R_FRG3G Uncharacterized protein 027R
048L_FRG3G Uncharacterized protein 048L
053R_FRG3G Putative myristoylated protein 053R
055R_FRG3G Uncharacterized protein 055R
056R_FRG3G Uncharacterized protein 056R
059L_FRG3G Uncharacterized protein 059L
061L_FRG3G Uncharacterized protein 061L
070R_FRG3G Uncharacterized protein 070R
072L_FRG3G Uncharacterized protein 072L
084R_FRG3G Uncharacterized protein 084R
087L_FRG3G Uncharacterized protein 087L
088R_FRG3G Putative FAD-linked sulfhydryl oxidase 088R (EC 1.8.3.2)
093L_FRG3G Uncharacterized protein 093L
094L_FRG3G Uncharacterized protein 094L
096R_FRG3G Uncharacterized protein 096R
002L_FRG3G Uncharacterized protein 002L
004R_FRG3G Uncharacterized protein 004R
006R_FRG3G Uncharacterized protein 006R
013R_FRG3G Uncharacterized protein 013R
015R_FRG3G Uncharacterized protein 015R
017L_FRG3G Uncharacterized protein 017L
097R_FRG3G Uncharacterized protein 097R
DPOL_FRG3G Putative DNA polymerase 060R (EC 2.7.7.7)
DUT_FRG3G Putative deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23)
DNK_FRG3G Putative deoxynucleoside kinase (EC 2.7.1.-)
DNMT_FRG3G Putative DNA (cytosine-5)-methyltransferase (EC 2.1.1.37)
ICP18_FRG3G Immediate-early protein ICP-18
ICP46_FRG3G Immediate-early protein ICP-46
MCP_FRG3G Major capsid protein (MCP) (P50)
O22R_FRG3G Putative helicase 022R (EC 3.6.4.-)
RIR2_FRG3G Putative ribonucleoside-diphosphate reductase small subunit 067L (EC 1.17.4.1)
RIR1_FRG3G Putative ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleotide reductase ...
RNC_FRG3G Putative ribonuclease 3 (EC 3.1.26.3) (Ribonuclease III) (RNase III)
RPB1_FRG3G Putative DNA-directed RNA polymerase 008R (EC 2.7.7.6)
RPB2_FRG3G Putative DNA-directed RNA polymerase II subunit RPB2 homolog (EC 2.7.7.6)

1 entry

Rana tigrina ranavirus

MCP_RTRV Major capsid protein (MCP) (P50)