Inhibition of host MDA5 by virus

Upon viral infection, the cytosolic receptor MDA5(AF095844:9606) recognizes long viral dsRNAs and initiates an antiviral signaling cascade by interacting with the downstream partner MAVS, located to the mitochondria. This signaling pathway leads to the establishment of an antiviral state characterized by expression of antiviral cytokines and interferons. The MDA5(AF095844:9606) protein belongs to the RNA helicase family.

RIGI RIGI TRIM25 MAVS STING TRADD TRADD TRAF3 TRAF6 TRAF2 FADD RIP1 TBK1 IKKe IRF3 IRF3 IRF7 IRF7 IKb IKb DDX3 IKKgamma IKKalpha IKKbeta NFKB NFKB NFKB

Several viruses encode proteins that directly interfere with MDA5(AF095844:9606) to decrease interferon production by infected cells. For example, all viruses from paramyxovirinae subfamily encode a protein V(O55777) able to interact with MDA5(AF095844:9606) and block MDA5(AF095844:9606) interaction with MAVS, its downstream partner in the cascade. The interaction has been investigated in detail and the C-terminal domain of the V proteins is responsible for the binding of the helicase domain of protein V(O55777).

Matching UniProtKB/Swiss-Prot entries

31 entries grouped by strain (browse by keywords)

All proteins are shown (view only 17 complete proteome entries)

1 entry

Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain

V_HENDH Non-structural protein V

1 entry

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

RNB_HHV11 RNA-binding protein (Vmw21)

1 entry

Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

RNB_HHV2H Probable RNA-binding protein

1 entry

Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain

V_PI2HT Non-structural protein V

1 entry

Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain

V_MEASC Non-structural protein V

1 entry

Mumps virus (strain Miyahara vaccine) (MuV) reference strain

V_MUMPM Non-structural protein V (Non-structural protein NS1)

1 entry

Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain

V_NDVB1 Protein V

1 entry

Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain

V_PIV5 Non-structural protein V

1 entry

Sendai virus (strain Ohita) (SeV) reference strain

V_SENDO Protein V

1 entry

Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain

V_SENDZ Protein V

1 entry

Simian virus 41 (SV41) reference strain

V_SV41 Non-structural protein V

1 entry

Tupaia paramyxovirus (TPMV) reference strain

V_TPMV Non-structural protein V

1 entry

Human herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)

RNB_HHV1M RNA-binding protein (Vmw21)

1 entry

Human parainfluenza 2 virus (HPIV-2)

V_PI2H Non-structural protein V

1 entry

Human parainfluenza 4a virus (strain Toshiba) (HPIV-4a)

V_PI4HA Non-structural protein V

1 entry

Human parainfluenza 4b virus (strain 68-333) (HPIV-4b)

V_PI4HB Non-structural protein V

1 entry

Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASE Non-structural protein V

1 entry

Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASA Non-structural protein V

1 entry

Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASI Non-structural protein V

1 entry

Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASY Non-structural protein V

1 entry

Mumps virus (strain Enders) (MuV)

V_MUMPE Non-structural protein V (Non-structural protein NS1)

1 entry

Mumps virus (strain SBL) (MuV)

V_MUMPS Non-structural protein V (Non-structural protein NS1)

1 entry

Mumps virus (strain SBL-1) (MuV)

V_MUMP1 Non-structural protein V (Non-structural protein NS1)

1 entry

Newcastle disease virus (strain Ulster/2C) (NDV)

V_NDVU2 Non-structural protein V

1 entry

Nipah virus

V_NIPAV Non-structural protein V

1 entry

Phocine distemper virus (PDV)

V_PHODV Non-structural protein V

1 entry

Rinderpest virus (strain Kabete O) (RDV)

V_RINDK Non-structural protein V

1 entry

Rinderpest virus (strain RBOK) (RDV)

V_RINDR Non-structural protein V

1 entry

Sendai virus (strain Fushimi) (SeV)

V_SENDF Protein V

1 entry

Sendai virus (strain Hamamatsu) (SeV)

V_SENDA Protein V

1 entry

Sendai virus (strain Harris) (SeV)

V_SENDH Protein V