Inhibition of host MDA5 by virus

Upon viral infection, the cytosolic receptor MDA5(AF095844:9606) recognizes long viral dsRNAs and initiates an antiviral signaling cascade by interacting with the downstream partner MAVS, located to the mitochondria. This signaling pathway leads to the establishment of an antiviral state characterized by expression of antiviral cytokines and interferons. The MDA5(AF095844:9606) protein belongs to the RNA helicase family.

RIGI RIGI TRIM25 MAVS STING TRADD TRADD TRAF3 TRAF6 TRAF2 FADD RIP1 TBK1 IKKe IRF3 IRF3 IRF7 IRF7 IKb IKb DDX3 IKKgamma IKKalpha IKKbeta NFKB NFKB NFKB

Several viruses encode proteins that directly interfere with MDA5(AF095844:9606) to decrease interferon production by infected cells. For example, all viruses from paramyxovirinae subfamily encode a protein V(O55777) able to interact with MDA5(AF095844:9606) and block MDA5(AF095844:9606) interaction with MAVS, its downstream partner in the cascade. The interaction has been investigated in detail and the C-terminal domain of the V proteins is responsible for the binding of the helicase domain of protein V(O55777).

Matching UniProtKB/Swiss-Prot entries

17 entries grouped by protein (browse by keywords)

Only complete proteome entries are shown (view all 31 entries)

2 entries

Probable RNA-binding protein

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RNB_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

RNA-binding protein (Vmw21)

RNB_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

15 entries

Non-structural protein V

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V_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
V_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
V_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain

Non-structural protein V (Non-structural protein NS1)

V_NDVB1
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain

Protein V

V_PI2HT
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
V_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
V_SENDO
Sendai virus (strain Ohita) (SeV) reference strain

Protein V

V_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain

Protein V

V_SV41
Simian virus 41 (SV41) reference strain
V_TPMV
Tupaia paramyxovirus (TPMV) reference strain
V_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
V_NIPAV
Nipah virus
V_SENDA
Sendai virus (strain Hamamatsu) (SeV)

Protein V

V_SENDF
Sendai virus (strain Fushimi) (SeV)

Protein V