Fijivirus

VIRION

Non enveloped, icosahedral virion with a double capsid structure, about 65-70 nm in diameter. Pentameric turrets sit on the outside of the innermost capsid. The outer capsid has a T=13 icosahedral symmetry, the inner capsid a T=2* icosahedral symmetry.

GENOME

Segmented linear dsRNA genome. Contains 10 segments coding for 12 proteins. Segments size range from 1.4 to 4.5 kb. Genome total size is about 27-30 kb.

GENE EXPRESSION

The dsRNA genome is never completely uncoated, to prevent activation of antiviral state by the cell in response to dsRNA. The viral polymerase synthesizes a capped mRNA from each dsRNA segment. This capped mRNA is translocated to the cell cytoplasm where it is translated.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Particles are partially uncoated in endolysosomes, but not entirely, and penetrate in the cytoplasm.
  3. Early transcription of the dsRNA genome by viral polymerase occurs inside this sub-viral particle (naked core), so that dsRNA is never exposed to the cytoplasm.
  4. Full-length plus-strand transcripts from each of the dsRNA segments are synthesized. These plus-strand transcripts are used as templates for translation.
  5. Viral proteins and genomic RNAs aggregates in cytoplasmic viral factories.
  6. (+)RNAs are encapsidated in a sub-viral particle, in which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
  7. The capsid is assembled on the sub-viral particle.
  8. Mature virions are released presumably following cell death and associated breakdown of host plasma membrane.

Matching UniProtKB/Swiss-Prot entries

15 entries grouped by strain (browse by keywords)

All proteins are shown (view only 12 complete proteome entries)

12 entries

Fiji disease virus (isolate Sugarcane) (FDV) reference strain

Select_allDeselect_all
CAPSD_FDVS Putative major capsid protein
RDRP_FDVS RNA-directed RNA polymerase VP1 (EC 2.7.7.48)
VP5_FDVS Uncharacterized protein VP5
VP10_FDVS Putative outer capsid protein p10
VP91_FDVS Non-structural protein P9-1
VP3_FDVS Putative structural protein VP3
VP8_FDVS Microtubule-associated protein VP8
VP4_FDVS Uncharacterized protein VP4
VP71_FDVS Uncharacterized protein VP7-1
VP92_FDVS Uncharacterized protein VP9-2
VP6_FDVS Uncharacterized protein VP6
VP72_FDVS Uncharacterized protein VP7-2

2 entries

Maize rough dwarf virus (MRDV)

Select_allDeselect_all
VP61_MRDV Probable non-structural 41.0 kDa protein
VP62_MRDV Probable non-structural 36.3 kDa protein

1 entry

Rice black streaked dwarf virus (RBSDV)

VP10_RBSDV Protein S10