Rubivirus

VIRION

Enveloped, spherical, icosahedral, 65-70nm in diameter, capsid with a T=4 icosahedral symmetry made of 240 monomers. The envelope contains 80 trimer spikes, each spike = 3 x E1/E2 heterodimers.

GENOME

Monopartite, linear, ssRNA(+) genome of 9.7 kb. The genome is capped and polyadenylated.

GENE EXPRESSION

The virion RNA is infectious and serves as both genome and viral messenger RNA. The whole genome is translated in a non-structural polyprotein which is processed by host and viral proteases. Structural polyprotein is expressed through a subgenomic mRNA.

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral E glycoprotein to host receptors mediates clathrin-mediated endocytosis of virus into the host cell.
  2. Fusion of virus membrane with host endosomal membrane. RNA genome is released into the cytoplasm.
  3. The positive-sense genomic ssRNA is translated into a polyprotein, which is cleaved into non-structural proteins necessary for RNA synthesis (replication and transcription).
  4. Replication takes place in cytoplasmic viral factories at the surface of endosomes. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Expression of the subgenomic RNA (sgRNA) gives rise to the structural proteins.
  7. Capsid assembly occurs in cytoplasm.
  8. The capsid is envelopped by budding at the plasma membrane where the virion exits the cell.

Host-virus interaction

Host gene expression shutoff by virus

Rubella virus capsid protein (Rubivirus) seems to mediate host translation shutoff by inhibiting host poly(A)-binding protein. .

Matching UniProtKB/Swiss-Prot entries

18 entries grouped by strain (browse by keywords)

2 entries

Rubella virus (strain Therien) (RUBV) reference strain

Select_allDeselect_all
POLS_RUBVT Structural polyprotein (p110) [Cleaved into: Capsid protein (Coat protein) (C); E2 envelope ...
POLN_RUBVT Non-structural polyprotein p200 (p200) [Cleaved into: Protease p150 (p150) (EC 3.4.22.-); ...

2 entries

Rubella virus (strain BRD1) (RUBV)

Select_allDeselect_all
POLS_RUBVB Structural polyprotein (p110) [Cleaved into: Capsid protein (Coat protein) (C); E2 envelope ...
POLN_RUBVB Non-structural polyprotein p200 (p200) [Cleaved into: Protease p150 (p150) (EC 3.4.22.-); ...

2 entries

Rubella virus (strain BRDII) (RUBV)

Select_allDeselect_all
POLN_RUBVC Non-structural polyprotein p200 (p200) [Cleaved into: Protease p150 (p150) (EC 3.4.22.-); ...
POLS_RUBVC Structural polyprotein (p110) [Cleaved into: Capsid protein (Coat protein) (C); E2 envelope ...

2 entries

Rubella virus (strain Cendehill) (RUBV)

Select_allDeselect_all
POLN_RUBVD Non-structural polyprotein p200 (p200) [Cleaved into: Protease p150 (p150) (EC 3.4.22.-); ...
POLS_RUBVD Structural polyprotein (p110) [Cleaved into: Capsid protein (Coat protein) (C); E2 envelope ...

2 entries

Rubella virus (strain M33) (RUBV)

Select_allDeselect_all
POLN_RUBVM Non-structural polyprotein p200 (p200) [Cleaved into: Protease p150 (p150) (EC 3.4.22.-); ...
POLS_RUBVM Structural polyprotein (p110) [Cleaved into: Capsid protein (Coat protein) (C); E2 envelope ...

2 entries

Rubella virus (strain RA27/3 vaccine) (RUBV)

Select_allDeselect_all
POLN_RUBVR Non-structural polyprotein p200 (p200) [Cleaved into: Protease p150 (p150) (EC 3.4.22.-); ...
POLS_RUBVR Structural polyprotein (p110) [Cleaved into: Capsid protein (Coat protein) (C); E2 envelope ...

2 entries

Rubella virus (strain RN-UK86) (RUBV)

Select_allDeselect_all
POLN_RUBVN Non-structural polyprotein p200 (p200) [Cleaved into: Protease p150 (p150) (EC 3.4.22.-); ...
POLS_RUBVN Structural polyprotein (p110) [Cleaved into: Capsid protein (Coat protein) (C); E2 envelope ...

2 entries

Rubella virus (strain TO-336 vaccine) (RUBV)

Select_allDeselect_all
POLS_RUBVO Structural polyprotein (p110) [Cleaved into: Capsid protein (Coat protein) (C); E2 envelope ...
POLN_RUBVO Non-structural polyprotein p200 (p200) [Cleaved into: Protease p150 (p150) (EC 3.4.22.-); ...

2 entries

Rubella virus (strain TO-336) (RUBV)

Select_allDeselect_all
POLN_RUBVV Non-structural polyprotein p200 (p200) [Cleaved into: Protease p150 (p150) (EC 3.4.22.-); ...
POLS_RUBVV Structural polyprotein (p110) [Cleaved into: Capsid protein (Coat protein) (C); E2 envelope ...