Alpharetrovirus

VIRION

Enveloped, spherical to pleomorphic in shape, 80-100 nm in diameter.

GENOME

Monopartite, linear, dimeric, ssRNA(+) genome of about 7.2 kb, with a 5'-cap and a 3’poly-A tail. There are two long terminal repeats (LTRs) of about 600nt long at the 5' and 3' ends. The LTRs contain the U3, R, and U5 regions. There are also a primer binding site (PBS) at the 5’end and a polypurine tract (PPT) at the 3’end.

GENE EXPRESSION

The integrated provirus utilizes the promoter elements in the 5' LTR to drive transcription. This gives rise to the unspliced full length mRNA that will serve as genomic RNA to be packaged into virions or used as a template for translation of gag(pro) and gag(pro)-pol (1 ribosomal frameshift) polyproteins. The spliced mRNA encodes env that is cleaved into SU and TM envelope proteins. There are no additional genes other than gag, pro, pol and env.

REPLICATION

NUCLEAR

  1. Virus attaches to host receptors through the SU glycoprotein. TM glycoprotein mediates fusion with cell membrane.
  2. Internalization and partial uncoating.
  3. ssRNA(+) genome is copied into a linear dsDNA molecule by the reverse transcriptase.
  4. Nuclear entry of the viral dsDNA when the nuclear membrane is disassembled at mitosis.
  5. Viral dsDNA is covalently and randomly integrated into the cell’s genome by the viral integrase (=provirus).
  6. Transcription of provirus by Pol II produces viral spliced and unspliced RNAs.
  7. Nuclear export of the incompletely spliced RNAs.
  8. Translation of unspliced viral RNAs produces Env, Gag and Gag-Pol polyproteins.
  9. Assembly of the virion at the host cellular membrane and packaging of the viral RNA genome.
  10. Budding through the plasma membrane and release of the virions.
  11. Proteolytic processing of the precursors polyproteins by viral protease and maturation of the virions.

Matching UniProtKB/Swiss-Prot entries

47 entries grouped by strain (browse by keywords)

All proteins are shown (view only 17 complete proteome entries)

5 entries

Avian leukosis virus RSA (RSV-SRA) (Rous sarcoma virus (strain Schmidt-Ruppin A)) reference strain

Select_allDeselect_all
ENV_RSVSA Envelope glycoprotein gp95 (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 85) ...
GAG_RSVSA Gag-Pro polyprotein [Cleaved into: Matrix protein p19; p2A; p2B; p10; p3; Capsid protein p27; ...
POL_RSVSA Gag-Pro-Pol polyprotein [Cleaved into: Matrix protein p19; p2A; p2B; p10; p3; Capsid protein p27; ...
VP14_RSVSA Putative trans-acting factor
SRC_RSVSA Tyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) (p60-Src) (v-Src)

4 entries

Rous sarcoma virus (strain Prague C) (RSV-PrC)

Select_allDeselect_all
ENV_RSVP Envelope glycoprotein gp95 (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 85) ...
GAG_RSVP Gag-Pro polyprotein [Cleaved into: p3; Matrix protein p19; p2A; p2B; p10; Capsid protein p27; ...
POL_RSVP Gag-Pro-Pol polyprotein [Cleaved into: Matrix protein p19; p2A; p2B; p10; Capsid protein p27; p3; ...
SRC_RSVP Tyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) (p60-Src) (v-Src)

2 entries

Avian leukosis virus (ALV)

Select_allDeselect_all
ERBB_ALV Tyrosine-protein kinase transforming protein erbB (EC 2.7.10.1)
POL_ALV Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) ...

2 entries

Avian myelocytomatosis virus MC29

Select_allDeselect_all
GAG_AVIMC Gag polyprotein [Cleaved into: Matrix protein p19; Core protein p10; Core protein p27]
MYC_AVIMC Viral myc transforming protein (v-Myc)

2 entries

Avian retrovirus MH2

Select_allDeselect_all
MIL_AVIMH Serine/threonine-protein kinase-transforming protein mil (EC 2.7.11.1)
MYC_AVIMH Viral myc transforming protein (v-Myc)

2 entries

Fujinami sarcoma virus

Select_allDeselect_all
FPS_FUJSV Tyrosine-protein kinase transforming protein Fps (EC 2.7.10.2)
GAG_FUJSV Gag polyprotein [Cleaved into: Matrix protein p19; p10; Capsid protein p27]

2 entries

Rous sarcoma virus (strain Schmidt-Ruppin B) (RSV-SRB)

Select_allDeselect_all
GAG_RSVSB Gag-Pro polyprotein [Cleaved into: Matrix protein p19; p2A; p2B; p10; p3; Capsid protein p27; ...
POL_RSVSB Gag-Pro-Pol polyprotein [Cleaved into: Matrix protein p19; p2A; p2B; p10; Capsid protein p27; p3; ...

2 entries

UR2 sarcoma virus (UR2SV) (Avian sarcoma virus (strain UR2))

Select_allDeselect_all
GAG_AVISU Core protein p19 (Gag protein p19)
ROS_AVISU Tyrosine-protein kinase transforming protein ros (EC 2.7.10.1)

1 entry

Avian erythroblastosis virus (strain ES4)

ERBB_AVIER Tyrosine-protein kinase transforming protein erbB (EC 2.7.10.1)

1 entry

Avian erythroblastosis virus (strain S13)

SEA_AVIET Tyrosine-protein kinase transforming protein SEA (EC 2.7.10.2)

1 entry

Avian erythroblastosis virus (strain Sloan-Kettering)

SKI_AVIES Transforming protein Ski

1 entry

Avian erythroblastosis virus (strain ts167)

ERBB_AVIEU Tyrosine-protein kinase transforming protein erbB (EC 2.7.10.1)

1 entry

Avian musculoaponeurotic fibrosarcoma virus AS42

MAF_AVIS4 Transforming protein Maf

1 entry

Avian myeloblastosis associated virus (MAV)

GAG_AVIMA Proteinase p15 (EC 3.4.23.-)

1 entry

Avian myeloblastosis virus

MYB_AVIMB Transforming protein Myb

1 entry

Avian myelocytomatosis virus CMII

MYC_AVIM2 Viral myc transforming protein (v-Myc)

1 entry

Avian retrovirus IC10

RMIL_AVII1 Serine/threonine-protein kinase-transforming protein Rmil (EC 2.7.11.1)

1 entry

Avian retrovirus MH2E21

MYC_AVIME Viral myc transforming protein (v-Myc)

1 entry

Avian retrovirus NK24

FOS_AVINK p55-v-Fos-transforming protein

1 entry

Avian retrovirus OK10

MYC_AVIOK Viral myc transforming protein (v-Myc)

1 entry

Avian retrovirus RPL30

RYK_AVIR3 Tyrosine-protein kinase transforming protein RYK (EC 2.7.10.1)

1 entry

Avian rous-associated virus type 1

RMIL_AVEVR Serine/threonine-protein kinase-transforming protein Rmil (EC 2.7.11.1)

1 entry

Avian sarcoma virus (strain 17)

JUN_AVIS1 Viral jun-transforming protein (v-Jun)

1 entry

Avian sarcoma virus (strain 31) (ASV31)

QIN_AVIS3 Transforming protein Qin (Oncogene Qin)

1 entry

Avian sarcoma virus (strain CT10)

GAGC_AVISC P47(GAG-CRK) protein

1 entry

Avian sarcoma virus (strain PR2257)

SRC_AVIS2 Tyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) (p60-Src) (v-Src)

1 entry

Avian sarcoma virus (strain PRCII)

FPS_AVISP Tyrosine-protein kinase transforming protein Fps (EC 2.7.10.2)

1 entry

Avian sarcoma virus (strain S1)

SRC_AVISS Tyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) (p60-Src) (v-Src)

1 entry

Avian sarcoma virus (strain S2)

SRC_AVIST Tyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) (p60-Src) (v-Src)

1 entry

Avian sarcoma virus (strain Y73)

GAG_AVISY Gag polyprotein [Cleaved into: Matrix protein p19; Core protein p10]

1 entry

Avian sarcoma virus (strain rASV1441)

SRC_AVISR Tyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) (p60-Src) (v-Src)

1 entry

Rous sarcoma virus (strain H-19)

SRC_RSVH1 Tyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) (p60-Src) (v-Src)

1 entry

Rous sarcoma virus (strain PA101T)

SRC_RSVPA Tyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) (p60-Src) (v-Src)

1 entry

Rous sarcoma virus (strain Schmidt-Ruppin E) (RSV-SR-E)

SRC_RSVSE Tyrosine-protein kinase transforming protein Src (EC 2.7.10.2) (pp60v-src) (p60-Src) (v-Src)