Inhibition of host tetherin by virus

Tetherin(D28137:9606) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses, including human immunodeficiency virus type 1 (HIV-1), HIV-2, other retroviruses, Lassa virus-like particles (VLPs), Marburg and Ebola VLPs.
Tetherin may also act as an innate immune sensor of viral infections that activates NF-kappaB to induce an inflammatory response .

Several viruses manage to circumvent the antiviral activity of tetherin(D28137:9606). The Vpu(P05919) protein form HIV-1 bridges tetherin(D28137:9606) to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, inducing its ubiquitination and subsequent proteasomal degradation. HIV-2 instead downregulates cell surface expression of tetherin(D28137:9606), restricting it to the trans-Golgi network via direct interaction with the viral glycoprotein(P18094).

Matching UniProtKB/Swiss-Prot entries

35 entries grouped by strain (browse by keywords)

Only complete proteome entries are shown (view all 55 entries)

1 entry

Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1) reference strain

VPU_HV1MA Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) reference strain

VPU_HV1B1 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) reference strain

VPU_HV1H2 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate MN) (HIV-1) reference strain

VPU_HV1MN Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1) reference strain

VPU_HV1VI Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2) reference strain

ENV_HV2BE Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus) reference strain

VGP_EBORR Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; GP2-delta]

1 entry

Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain

VGP_EBOZM Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; GP2-delta]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1)

VPU_HV1A2 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1)

VPU_HV1BR Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1)

VPU_HV1JR Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1)

VPU_HV1RH Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1)

VPU_HV1Y2 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1)

VPU_HV1B9 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025) (HIV-1)

VPU_HV192 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype C (isolate ETH2220) (HIV-1)

VPU_HV1ET Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate ELI) (HIV-1)

VPU_HV1EL Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1)

VPU_HV193 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056) (HIV-1)

VPU_HV190 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group N (isolate YBF106) (HIV-1)

VPU_HV1YB Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1)

VPU_HV1YF Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1)

VPU_HV1AN Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1)

VPU_HV1MV Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate CAM2) (HIV-2)

ENV_HV2CA Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate D194) (HIV-2)

ENV_HV2D1 Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate Ghana-1) (HIV-2)

ENV_HV2G1 Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate KR) (HIV-2)

ENV_HV2KR Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2)

ENV_HV2RO Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate SBLISY) (HIV-2)

ENV_HV2SB Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate ST) (HIV-2)

ENV_HV2ST Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Human immunodeficiency virus type 2 subtype B (isolate EHO) (HIV-2)

ENV_HV2EH Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Human immunodeficiency virus type 2 subtype B (isolate UC1) (HIV-2)

ENV_HV2UC Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)

VGP_EBORE Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; GP2-delta]

1 entry

Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)

VGP_EBOSU Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; GP2-delta]

1 entry

Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)

VGP_EBOZ5 Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; GP2-delta]