Gammaretrovirus

Molecular biology

VIRION

Enveloped, spherical to pleomorphic in shape, 80-100 nm in diameter.

GENOME

Monopartite, linear, dimeric, ssRNA(+) genome of about 8.3 kb, with a 5'-cap and a 3’poly-A tail. There are two long terminal repeats (LTRs) of about 600nt long at the 5' and 3' ends. The LTRs contain the U3, R, and U5 regions. There are also a primer binding site (PBS) at the 5’end and a polypurine tract (PPT) at the 3’end.

GENE EXPRESSION

The integrated provirus utilizes the promoter elements in the 5’LTR to drive transcription. This gives rise to the unspliced full length mRNA that will serve as genomic RNA to be packaged into virions or used as a template for translation of gag, and gag-(pro)pol (suppression of termination of the gag termination codon). The spliced mRNA encodes env that is cleaved into SU and TM envelope proteins. Glyco-GAG is translated by noncanonical initiation of translation .

REPLICATION

NUCLEAR

  1. Virus attaches to host receptors through the SU glycoprotein. TM glycoprotein mediates fusion with cell membrane.
  2. Internalization and partial uncoating.
  3. ssRNA(+) genome is copied into a linear dsDNA molecule by the reverse transcriptase.
  4. Nuclear entry of the viral dsDNA when the nuclear membrane is disassembled at mitosis.
  5. Viral dsDNA is covalently and randomly integrated into the cell’s genome by the viral integrase (=provirus).
  6. Transcription of provirus by Pol II produces viral spliced and unspliced RNAs.
  7. Nuclear export of the incompletely spliced RNAs.
  8. Translation of unspliced viral RNAs produces Env, Gag and Gag-Pol polyproteins.
  9. Assembly of the virion at the host cellular membrane and packaging of the viral RNA genome.
  10. Budding through the plasma membrane and release of the virions.
  11. Proteolytic processing of the precursors polyproteins by viral protease and maturation of the virions.

Matching UniProtKB/Swiss-Prot entries

100 entries grouped by strain (browse by keywords)

All proteins are shown (view only 37 complete proteome entries)

3 entries

Moloney murine leukemia virus (isolate Shinnick) (MoMLV) reference strain

Select_allDeselect_all
ENV_MLVMS Envelope glycoprotein (Pr80env) (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein ...
GAG_MLVMS Gag polyprotein (Pr65gag) (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
POL_MLVMS Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

3 entries

Xenotropic MuLV-related virus (isolate VP62) (XMRV) reference strain

Select_allDeselect_all
ENV_XMRV6 Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein ...
GAG_XMRV6 Gag polyprotein (Pr65gag) (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
POL_XMRV6 Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

3 entries

AKV murine leukemia virus (AKR (endogenous) murine leukemia virus)

Select_allDeselect_all
ENV_MLVAV Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
GAG_MLVAV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
POL_MLVAV Pol polyprotein [Cleaved into: Protease (EC 3.4.23.-); Reverse transcriptase/ribonuclease H (RT) (EC ...

3 entries

Abelson murine leukemia virus

Select_allDeselect_all
ABL_MLVAB Tyrosine-protein kinase transforming protein Abl (EC 2.7.10.2) (V-abl)
GAG_MLVAB Gag polyprotein [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12; Capsid ...
V18K_MLVAB 18 kDa protein

3 entries

Baboon endogenous virus (strain M7)

Select_allDeselect_all
ENV_BAEVM Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
GAG_BAEVM Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
POL_BAEVM Pol polyprotein [Cleaved into: Protease (EC 3.4.23.-); Reverse transcriptase/ribonuclease H (RT) (EC ...

3 entries

Feline leukemia virus

Select_allDeselect_all
GAG_FLV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
MYC_FLV Viral myc transforming protein (v-Myc)
TCB_FLV Viral T-cell receptor beta chain-like T17T-22

3 entries

Feline sarcoma virus (strain Gardner-Arnstein) (Ga-FeSV) (Gardner-Arnstein feline leukemia oncovirus B)

Select_allDeselect_all
ENV_FSVGA Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
FES_FSVGA Tyrosine-protein kinase transforming protein Fes (EC 2.7.10.2)
GAG_FSVGA Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

3 entries

Friend murine leukemia virus (isolate 57) (FrMLV)

Select_allDeselect_all
ENV_MLVF5 Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
GAG_MLVF5 Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 ...
POL_MLVF5 Pol polyprotein [Cleaved into: Protease (EC 3.4.23.-); Reverse transcriptase/ribonuclease H (RT) (EC ...

3 entries

Friend murine leukemia virus (isolate FB29) (FrMLV)

Select_allDeselect_all
ENV_MLVFF Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
GAG_MLVFF Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 ...
POL_MLVFF Pol polyprotein [Cleaved into: Protease (EC 3.4.23.-); Reverse transcriptase/ribonuclease H (RT) (EC ...

3 entries

Friend murine leukemia virus (isolate PVC-211) (FrMLV)

Select_allDeselect_all
ENV_MLVFP Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
GAG_MLVFP Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 ...
POL_MLVFP Pol polyprotein [Cleaved into: Protease (EC 3.4.23.-); Reverse transcriptase/ribonuclease H (RT) (EC ...

3 entries

Gibbon ape leukemia virus (GALV)

Select_allDeselect_all
ENV_GALV Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
GAG_GALV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
POL_GALV Pol polyprotein [Cleaved into: Protease (EC 3.4.23.-); Reverse transcriptase/ribonuclease H (RT) (EC ...

3 entries

Koala retrovirus (KoRV)

Select_allDeselect_all
ENV_KORV Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
GAG_KORV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
POL_KORV Pro-Pol polyprotein (Pr125Pol) [Cleaved into: Protease/Reverse transcriptase/ribonuclease H (EC ...

3 entries

Moloney murine sarcoma virus (MoMSV)

Select_allDeselect_all
GAG_MSVMO Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
MOS_MSVMO Serine/threonine-protein kinase-transforming protein mos (EC 2.7.11.1)
RASH_MSVMO GTPase HRas (Transforming protein p21/H-Ras)

3 entries

Radiation murine leukemia virus

Select_allDeselect_all
ENV_MLVRD Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 76) ...
GAG_MLVRD Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
POL_MLVRD Pol polyprotein [Cleaved into: Protease (EC 3.4.23.-); Reverse transcriptase/ribonuclease H (RT) (EC ...

3 entries

Xenotropic MuLV-related virus (isolate VP35) (XMRV)

Select_allDeselect_all
ENV_XMRV3 Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein ...
GAG_XMRV3 Gag polyprotein (Pr65gag) (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
POL_XMRV3 Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

3 entries

Xenotropic MuLV-related virus (isolate VP42) (XMRV)

Select_allDeselect_all
ENV_XMRV4 Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein ...
GAG_XMRV4 Gag polyprotein (Pr65gag) (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
POL_XMRV4 Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

2 entries

Avian reticuloendotheliosis virus

Select_allDeselect_all
ENV_AVIRE Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 73) ...
REL_AVIRE Transforming protein rel polyprotein (p58 V-rel) [Cleaved into: Env polyprotein N-terminal; ...

2 entries

Cas-Br-E murine leukemia virus

Select_allDeselect_all
ENV_MLVCB Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
GAG_MLVCB Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

2 entries

FBR murine osteosarcoma virus (FBR-MSV) (Finkel-Biskis-Reilly murine osteosarcoma virus)

Select_allDeselect_all
FOSX_MSVFR Transforming protein v-Fos/v-Fox
GAG_MSVFR Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

2 entries

Feline sarcoma virus (strain Gardner-Rasheed)

Select_allDeselect_all
FGR_FSVGR Tyrosine-protein kinase transforming protein Fgr (EC 2.7.10.2)
GAG_FSVGR Core protein p15

2 entries

Feline sarcoma virus (strain McDonough)

Select_allDeselect_all
GAG_FSVMD Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
KFMS_FSVMD Tyrosine-protein kinase transforming protein fms (EC 2.7.10.1)

2 entries

Feline sarcoma virus (strain Snyder-Theilen)

Select_allDeselect_all
FES_FSVST Tyrosine-protein kinase transforming protein Fes (EC 2.7.10.2)
GAG_FSVST Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

2 entries

Friend spleen focus-forming virus (isolate 502) (FSFFV)

Select_allDeselect_all
ENV_FRSF5 Glycoprotein 55 (gp55)
GAG_FRSF5 Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

2 entries

Hortulanus murine leukemia virus (HoMuLV) (Mus hortulanus virus)

Select_allDeselect_all
ENV_MLVHO Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 76) ...
GAG_MLVHO Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

2 entries

Moloney murine sarcoma virus (strain ts110) (MoMSV)

Select_allDeselect_all
GAG_MSVMT Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
MOS_MSVMT Serine/threonine-protein kinase-transforming protein mos (EC 2.7.11.1)

2 entries

Woolly monkey sarcoma virus (WMSV) (Smian sarcoma-associated virus)

Select_allDeselect_all
GAG_WMSV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
TSIS_WMSV PDGF-related-transforming protein sis (p28sis)

1 entry

AKT8 murine leukemia virus

AKT_MLVAT AKT kinase-transforming protein (EC 2.7.11.1)

1 entry

Avian spleen necrosis virus

ENV_AVISN Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 73) ...

1 entry

Cas-NS-1 murine leukemia virus

CBL_MLVCN Transforming protein cbl

1 entry

Duplan murine leukemia virus

GAG_MLVDU Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

FBJ murine osteosarcoma virus (FBJ-MSV) (Finkel-Biskis-Jinkins murine osteosarcoma virus)

FOS_MSVFB p55-v-Fos-transforming protein

1 entry

Feline endogenous virus ECE1

ENV_FENV1 Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

1 entry

Feline leukemia virus (isolate CFE-6)

ENV_FLVC6 Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

1 entry

Feline leukemia virus (strain A/Glasgow-1)

ENV_FLVGL Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

1 entry

Feline leukemia virus (strain B/lambda-B1)

ENV_FLVLB Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

1 entry

Feline leukemia virus (strain C/Sarma)

ENV_FLVSA Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

1 entry

Feline leukemia virus FTT

MYC_FLVTT Viral myc transforming protein (v-Myc)

1 entry

Feline sarcoma virus (strain Hardy-Zuckerman 2)

ABL_FSVHY Tyrosine-protein kinase transforming protein Abl (EC 2.7.10.2) (V-abl)

1 entry

Feline sarcoma virus (strain Hardy-Zuckerman 4)

KIT_FSVHZ Tyrosine-protein kinase transforming protein kit (EC 2.7.10.1)

1 entry

Feline sarcoma virus (strain SM) (Sm-FeSV)

ENV_FSVSM Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

1 entry

Friend spleen focus-forming virus (strain BB6) (FSFFV)

ENV_FRSFB Glycoprotein 42 (gp42)

1 entry

Friend spleen focus-forming virus (strain Lilly-Steeves) (FSFFV)

ENV_FRSFL Glycoprotein 55 (gp55)

1 entry

Harvey murine sarcoma virus

RASH_MSVHA Transforming protein p29 [Cleaved into: Transforming protein p21]

1 entry

Kirsten murine sarcoma virus

RASK_MSVKI GTPase KRas (Ki-Ras) (Transforming protein p21/K-Ras)

1 entry

Mink cell focus-forming murine leukemia virus

ENV_MCFF Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

1 entry

Mink cell focus-forming murine leukemia virus (isolate CI-3)

ENV_MCFF3 Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

1 entry

Moloney murine leukemia virus (strain neuropathogenic variant ts1-92b) (MoMLV)

GAG80_MLVMN Glycosylated Gag polyprotein (Pr80gag) (Glyco-gag) (gp80gag) [Cleaved into: Nextended-MA-p12; CA-NC]

1 entry

Moloney murine sarcoma virus (strain HT-1) (MoMSV)

MOS_MSVMH Serine/threonine-protein kinase-transforming protein mos (EC 2.7.11.1)

1 entry

Moloney murine sarcoma virus (strain m1) (MoMSV)

MOS_MSVMM Serine/threonine-protein kinase-transforming protein mos (EC 2.7.11.1)

1 entry

Murine leukemia virus (strain BM5 eco)

GAG_MLVBM Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Murine leukemia virus (strain DEF27)

GAG_MLVDE Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Murine sarcoma virus 3611

RAF_MSV36 Serine/threonine-protein kinase-transforming protein raf (EC 2.7.11.1)

1 entry

Murine sarcoma virus NS.C58

RASH_MSVNS GTPase HRas (Transforming protein p21/H-Ras)

1 entry

Myeloproliferative sarcoma virus (isolate ts159)

MOS_MSVTS Serine/threonine-protein kinase-transforming protein mos (EC 2.7.11.1)

1 entry

Radiation murine leukemia virus (strain Kaplan)

ENV_MLVRK Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 76) ...

1 entry

Rasheed rat sarcoma virus

RASH_RRASV Transforming protein p29 [Cleaved into: Transforming protein p21]

1 entry

Rauscher mink cell focus-inducing virus

ENV_RMCFV Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

1 entry

Rauscher spleen focus-forming virus (RSFFV)

ENV_RSFFV Glycoprotein 55 (gp55)