Inhibition of host MAVS by virus

The MAVS protein is required for innate immune defense against viruses. It acts downstream of RIG-I(AF038963:9606) and MDA5(AF095844:9606), which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to induction of antiviral cytokines. Alternatively, MAVS can cause apoptosis independent of its function in initiating interferon production. MAVS harbors a C-terminal transmembrane domain that targets it to the mitochondrial outer membrane.

RIGI RIGI TRIM25 MAVS STING TRADD TRADD TRAF3 TRAF6 TRAF2 FADD RIP1 TBK1 IKKe IRF3 IRF3 IRF7 IRF7 IKb IKb DDX3 IKKgamma IKKalpha IKKbeta NFKB NFKB NFKB

Some viruses selectively inhibit MAVS function. For example, Hepatitis C virus encodes a specific serine protease NS3/4A(P27958) which cleaves the MAVS transmembrane domain, removes it from the mitochondria thereby preventing interferon production. In a similar way, Hepatitis A encodes for the ABC protein(P08617), which localizes to the mitochondria and inhibits MAVS signaling via proteolytic cleavage.

Matching UniProtKB/Swiss-Prot entries

161 entries grouped by protein (browse by keywords)

All proteins are shown (view only 120 complete proteome entries)

1 entry

Matrix protein M2-2

M22_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain

7 entries

Non-structural protein 1 (Non-structural protein 1C)

Select_allDeselect_all
NS1_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
NS1_HRSVA
Human respiratory syncytial virus A (strain A2) reference strain

Non-structural protein 1 (NS1) (Non-structural protein 1C)

NS1_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
NS1_HRSS2
Human respiratory syncytial virus A (strain S-2) (HRSV-S2)

Non-structural protein 1 (NS1) (Non-structural protein 1C)

NS1_HRSV1
Human respiratory syncytial virus B (strain 18537)
NS1_HRSVL
Human respiratory syncytial virus A (strain Long)
NS1_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

56 entries

Protein PB1-F2

Select_allDeselect_all
PB1F2_I34A1
Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain
PB1F2_I49A1
Influenza A virus (strain A/Duck/Germany/1949 H10N7) reference strain
PB1F2_I68A4
Influenza A virus (strain A/Hong Kong/1/1968 H3N2) reference strain
PB1F2_I77AF
Influenza A virus (strain A/Gull/Maryland/704/1977 H13N6) reference strain
PB1F2_I96A0
Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
PB1F2_I00A0
Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
PB1F2_I01A0
Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
PB1F2_I01A1
Influenza A virus (strain A/Chicken/Hong Kong/YU562/2001 H5N1 genotype B)
PB1F2_I01A2
Influenza A virus (strain A/Chicken/Hong Kong/FY150/2001 H5N1 genotype D)
PB1F2_I01A3
Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
PB1F2_I02A1
Influenza A virus (strain A/Guinea fowl/Hong Kong/38/2002 H5N1 genotype X0)
PB1F2_I02A2
Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
PB1F2_I02A3
Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)
PB1F2_I02A4
Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)
PB1F2_I02A5
Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
PB1F2_I02A6
Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
PB1F2_I02A7
Influenza A virus (strain A/Teal/China/2978.1/2002 H5N1 genotype W)
PB1F2_I03A0
Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
PB1F2_I03A1
Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
PB1F2_I05A1
Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
PB1F2_I06A0
Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)
PB1F2_I18A0
Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))
PB1F2_I33A0
Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))
PB1F2_I35A3
Influenza A virus (strain A/USA:Phila/1935 H1N1)
PB1F2_I36A0
Influenza A virus (strain A/Henry/1936 H1N1)
PB1F2_I40A0
Influenza A virus (strain A/Hickox/1940 H1N1)
PB1F2_I43A0
Influenza A virus (strain A/USA:Iowa/1943 H1N1)
PB1F2_I45A0
Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)
PB1F2_I56A1
Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)
PB1F2_I56A2
Influenza A virus (strain A/Duck/England/1/1956 H11N6)
PB1F2_I59A0
Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
PB1F2_I60A0
Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)
PB1F2_I66A0
Influenza A virus (strain A/Turkey/Ontario/7732/1966 H5N9)
PB1F2_I66A1
Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)
PB1F2_I68A3
Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)
PB1F2_I71A1
Influenza A virus (strain A/Memphis/1/1971 H3N2)
PB1F2_I72A3
Influenza A virus (strain A/Memphis/102/1972 H3N2)
PB1F2_I72A4
Influenza A virus (strain A/Memphis/101/1972 H3N2)
PB1F2_I73A5
Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)
PB1F2_I75A0
Influenza A virus (strain A/Beijing/39/1975 H3N2)
PB1F2_I76A6
Influenza A virus (strain A/Memphis/110/1976 H3N2)
PB1F2_I77A4
Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)
PB1F2_I78A7
Influenza A virus (strain A/Memphis/2/1978 H3N2)
PB1F2_I78A8
Influenza A virus (strain A/Memphis/18/1978 H3N2)
PB1F2_I78AC
Influenza A virus (strain A/Turkey/Minnesota/501/1978 H6N8)
PB1F2_I79A7
Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)
PB1F2_I80A2
Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7)
PB1F2_I80A4
Influenza A virus (strain A/Memphis/4/1980 H3N2)
PB1F2_I80A6
Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)
PB1F2_I80A8
Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2)
PB1F2_I83A4
Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)
PB1F2_I83A5
Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)
PB1F2_I83A6
Influenza A virus (strain A/Chicken/Pennsylvania/1370/1983 H5N2)
PB1F2_I83A8
Influenza A virus (strain A/Hong Kong/5/1983 H3N2)
PB1F2_I85A3
Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)
PB1F2_I97A1
Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)

54 entries

Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

Select_allDeselect_all
PB2_I34A1
Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain
PB2_I49A1
Influenza A virus (strain A/Duck/Germany/1949 H10N7) reference strain
PB2_I68A4
Influenza A virus (strain A/Hong Kong/1/1968 H3N2) reference strain
PB2_I000X
Influenza A virus (strain A/X-31 H3N2)
PB2_I00A1
Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)
PB2_I06A0
Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)
PB2_I07A0
Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)
PB2_I18A0
Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))
PB2_I30A0
Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)
PB2_I33A0
Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))
PB2_I35A3
Influenza A virus (strain A/USA:Phila/1935 H1N1)
PB2_I36A0
Influenza A virus (strain A/Henry/1936 H1N1)
PB2_I40A0
Influenza A virus (strain A/Hickox/1940 H1N1)
PB2_I43A0
Influenza A virus (strain A/USA:Iowa/1943 H1N1)
PB2_I45A0
Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)
PB2_I47A0
Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)
PB2_I51A0
Influenza A virus (strain A/USA:Albany/12/1951 H1N1)
PB2_I54A2
Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)
PB2_I57A0
Influenza A virus (strain A/Japan/305/1957 H2N2)
PB2_I57A1
Influenza A virus (strain A/Leningrad/134/1957 H2N2)
PB2_I57A2
Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)
PB2_I57A3
Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)
PB2_I57A5
Influenza A virus (strain A/Singapore/1/1957 H2N2)
PB2_I60A0
Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)
PB2_I61A1
Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)
PB2_I67A0
Influenza A virus (strain A/Tokyo/3/1967 H2N2)
PB2_I67A2
Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)
PB2_I68A5
Influenza A virus (strain A/Korea/426/1968 H2N2)
PB2_I68A6
Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus (strain NT60)) (Influenza A virus (strain A/NT/60/1968 H3N2))
PB2_I69A0
Influenza A virus (strain A/England/878/1969 H3N2)
PB2_I70A0
Influenza A virus (strain A/Qu/7/1970 H3N2)
PB2_I71A1
Influenza A virus (strain A/Memphis/1/1971 H3N2)
PB2_I72A2
Influenza A virus (strain A/Udorn/307/1972 H3N2)
PB2_I72A3
Influenza A virus (strain A/Memphis/102/1972 H3N2)
PB2_I72A4
Influenza A virus (strain A/Memphis/101/1972 H3N2)
PB2_I73A5
Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)
PB2_I75A0
Influenza A virus (strain A/Beijing/39/1975 H3N2)
PB2_I75A3
Influenza A virus (strain A/Victoria/3/1975 H3N2)
PB2_I76A6
Influenza A virus (strain A/Memphis/110/1976 H3N2)
PB2_I77A4
Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)
PB2_I77AA
Influenza A virus (strain A/Brazil/11/1978 H1N1)
PB2_I77AB
Influenza A virus (strain A/USSR/90/1977 H1N1)
PB2_I77AC
Influenza A virus (strain A/Swine/Tennessee/24/1977 H1N1)
PB2_I78A7
Influenza A virus (strain A/Memphis/2/1978 H3N2)
PB2_I78A8
Influenza A virus (strain A/Memphis/18/1978 H3N2)
PB2_I79A4
Influenza A virus (strain A/Kiev/59/1979 H1N1)
PB2_I80A4
Influenza A virus (strain A/Memphis/4/1980 H3N2)
PB2_I80AA
Influenza A virus (strain A/India/6263/1980 H1N1)
PB2_I83A1
Influenza A virus (strain A/Chile/1/1983 H1N1)
PB2_I83A8
Influenza A virus (strain A/Hong Kong/5/1983 H3N2)
PB2_I88A3
Influenza A virus (strain A/Memphis/8/1988 H3N2)
PB2_I93A0
Influenza A virus (strain A/Kitakyushu/159/1993 H3N2)
PB2_I96A2
Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)
PB2_I96A3
Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)

43 entries

Genome polyprotein

Select_allDeselect_all
POLG_HAVHM
Human hepatitis A virus genotype IB (isolate HM175) (HHAV) (Human hepatitis A virus (isolate Human/Australia/HM175/1976)) reference strain
POLG_HCVH
Hepatitis C virus genotype 1a (isolate H) (HCV) reference strain
POLG_GBVB
Hepatitis GB virus B (GBV-B) (GB virus B)
POLG_HAV88
Human hepatitis A virus genotype IIB (isolate SLF88) (HHAV) (Human hepatitis A virus (isolate Human/Sierra Leone/SLF88/1988))
POLG_HAVCF
Human hepatitis A virus genotype IIA (isolate CF-53) (HHAV) (Human hepatitis A virus (isolate Human/France/CF-53/1979))
POLG_HAVGB
Human hepatitis A virus genotype IA (isolate GBM) (HHAV) (Human hepatitis A virus (isolate Human/Germany/GBM/1976))
POLG_HAVH2
Human hepatitis A virus genotype IA (isolate H2) (HHAV) (Human hepatitis A virus (isolate Human/China/H2/1982))
POLG_HAVJ8
Human hepatitis A virus genotype IIIB (isolate HAJ85-1) (HHAV) (Human hepatitis A virus (isolate Human/Japan/HAJ85-1/1985))
POLG_HAVLA
Human hepatitis A virus genotype IA (isolate LA) (HHAV) (Human hepatitis A virus (isolate Human/Northern California/LA/1974))
POLG_HAVMB
Human hepatitis A virus genotype IB (isolate MBB) (HHAV) (Human hepatitis A virus (isolate Human/Northern Africa/MBB/1978))
POLG_HAVNO
Human hepatitis A virus genotype IIIA (isolate NOR-21) (HHAV) (Human hepatitis A virus (isolate Human/Norway/NOR-21/1998))
POLG_HAVS2
Simian hepatitis A virus genotype V (isolate AGM-27) (SHAV) (Simian hepatitis A virus (isolate Cercopithecus/Kenya/AGM-27/1985))
POLG_HCV1
Hepatitis C virus genotype 1a (isolate 1) (HCV)
POLG_HCV6A
Hepatitis C virus genotype 6a (isolate 6a33) (HCV)
POLG_HCVBB
Hepatitis C virus genotype 2c (isolate BEBE1) (HCV)
POLG_HCVCO
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
POLG_HCVED
Hepatitis C virus genotype 4a (isolate ED43) (HCV)
POLG_HCVEU
Hepatitis C virus genotype 6a (isolate EUHK2) (HCV)
POLG_HCVEV
Hepatitis C virus genotype 5a (isolate EUH1480) (HCV)
POLG_HCVH9
Hepatitis C virus genotype 1c (isolate HC-G9) (HCV)
POLG_HCVIN
Hepatitis C virus genotype 1c (isolate India) (HCV)
POLG_HCVJ1
Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)
POLG_HCVJ4
Hepatitis C virus genotype 1b (strain HC-J4) (HCV)
POLG_HCVJ6
Hepatitis C virus genotype 2a (isolate HC-J6) (HCV)
POLG_HCVJ8
Hepatitis C virus genotype 2b (isolate HC-J8) (HCV)
POLG_HCVJA
Hepatitis C virus genotype 1b (isolate Japanese) (HCV)
POLG_HCVJF
Hepatitis C virus genotype 2a (isolate JFH-1) (HCV)
POLG_HCVJK
Hepatitis C virus genotype 3k (isolate JK049) (HCV)
POLG_HCVJL
Hepatitis C virus genotype 6g (isolate JK046) (HCV)
POLG_HCVJP
Hepatitis C virus genotype 2b (isolate JPUT971017) (HCV)
POLG_HCVJT
Hepatitis C virus genotype 1b (isolate HC-JT) (HCV)
POLG_HCVK3
Hepatitis C virus genotype 3a (isolate k3a) (HCV)
POLG_HCVNZ
Hepatitis C virus genotype 3a (isolate NZL1) (HCV)
POLG_HCVR6
Hepatitis C virus genotype 1b (isolate HCR6) (HCV)
POLG_HCVSA
Hepatitis C virus genotype 5a (isolate SA13) (HCV)
POLG_HCVT5
Hepatitis C virus genotype 6b (isolate Th580) (HCV)
POLG_HCVTR
Hepatitis C virus genotype 3b (isolate Tr-Kj) (HCV)
POLG_HCVTW
Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)
POLG_HCVVA
Hepatitis C virus genotype 2k (isolate VAT96) (HCV)
POLG_HCVVN
Hepatitis C virus genotype 6d (isolate VN235) (HCV)
POLG_HCVVO
Hepatitis C virus genotype 6k (isolate VN405) (HCV)
POLG_HCVVP
Hepatitis C virus genotype 6h (isolate VN004) (HCV)