Inhibition of host TYK2 by virus

Tyrosine kinase 2 TYK2(X54637:9606) is a member of IFNα/β signaling that belongs to the Janus kinase (JAK) family. Activation of TYK2(X54637:9606) by IFNα/β stimulation leads to a series of phosphorylation events, causing the formation of IFN stimulated gene factor 3 (ISGF3) complexes that consist of STAT1(M97935:9606), STAT2(M97934:9606) and IFN regulatory factor 9 IRF9(M87503:9606). Subsequently, ISGF3 translocates to the nucleus and binds to IFN stimulated response elements (IRF/ISRE), which in turn activates transcription of several hundred IFN-responsive genes.

INFRA1 INFRA2 INFRG1 INFRG2 JAK1 JAK1 TYK2 JAK2 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT2 STAT2 STAT2 STAT2 IRF9 IRF9 IRF9 LMP1 NS5 E6

Several viruses have evolved mechanisms to inhibit TYK2(X54637:9606) activity and prevent the subsequent activation of downstream partners STAT1(M97935:9606) and STAT2(M97934:9606). The Epstein-Barr virus LMP-1(P03230) protein interacts with TYK2(X54637:9606) and prevents its phosphorylation. Human papillomavirus E6(P03126) also interacts with and impair TYK2(X54637:9606) activation.

Matching UniProtKB/Swiss-Prot entries

36 entries grouped by protein (browse by keywords)

All proteins are shown (view only 33 complete proteome entries)

5 entries

Latent membrane protein 1 (LMP-1) (Protein p63)

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LMP1_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
LMP1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
LMP1_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4) reference strain
LMP1_EBVC
Epstein-Barr virus (strain Cao) (HHV-4) (Human herpesvirus 4)
LMP1_EBVR
Epstein-Barr virus (strain Raji) (HHV-4) (Human herpesvirus 4)

28 entries

Genome polyprotein

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POLG_DEN1W
Dengue virus type 1 (strain Nauru/West Pac/1974) (DENV-1) reference strain
POLG_ZIKV
Zika virus (strain Mr 766) (ZIKV) reference strain
POLG_DEN1B
Dengue virus type 1 (strain Brazil/97-11/1997) (DENV-1)
POLG_DEN1S
Dengue virus type 1 (strain Singapore/S275/1990) (DENV-1)
POLG_DEN26
Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2)
POLG_DEN27
Dengue virus type 2 (strain 16681-PDK53) (DENV-2)
POLG_DEN28
Dengue virus type 2 (isolate Thailand/0168/1979) (DENV-2)
POLG_DEN2J
Dengue virus type 2 (strain Jamaica/1409/1983) (DENV-2)
POLG_DEN2N
Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)
POLG_DEN2P
Dengue virus type 2 (strain Puerto Rico/PR159-S1/1969) (DENV-2)
POLG_DEN2Q
Dengue virus type 2 (strain Peru/IQT2913/1996) (DENV-2)
POLG_DEN3C
Dengue virus type 3 (strain China/80-2/1980) (DENV-3)
POLG_DEN3I
Dengue virus type 3 (strain Singapore/8120/1995) (DENV-3)
POLG_DEN3M
Dengue virus type 3 (strain Martinique/1243/1999) (DENV-3)
POLG_DEN3P
Dengue virus type 3 (strain Philippines/H87/1956) (DENV-3)
POLG_DEN3S
Dengue virus type 3 (strain Sri Lanka/1266/2000) (DENV-3)
POLG_DEN4D
Dengue virus type 4 (strain Dominica/814669/1981) (DENV-4)
POLG_DEN4H
Dengue virus type 4 (strain Thailand/0476/1997) (DENV-4)
POLG_DEN4P
Dengue virus type 4 (strain Philippines/H241/1956) (DENV-4)
POLG_DEN4S
Dengue virus type 4 (strain Singapore/8976/1995) (DENV-4)
POLG_DEN4T
Dengue virus type 4 (strain Thailand/0348/1991) (DENV-4)
POLG_JAEV1
Japanese encephalitis virus (strain SA-14)
POLG_JAEV5
Japanese encephalitis virus (strain SA(v))
POLG_JAEVJ
Japanese encephalitis virus (strain Jaoars982)
POLG_KUNJM
Kunjin virus (strain MRM61C)
POLG_LANVT
Langat virus (strain TP21)
POLG_USUV
Usutu virus (USUV)
POLG_WNV
West Nile virus (WNV)

3 entries

Non-structural protein V

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V_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
V_RINDR
Rinderpest virus (strain RBOK) (RDV)