Comovirinae

VIRION

Non-enveloped, 28-30 nm in diameter, T=pseudo3 icosahedral capsid. Genome segments are encapsidated separately into two different types of particle similar in size.

GENOME

Segmented, bipartite linear ssRNA(+) genome composed of RNA-1=6-8 kb and RNA-2=4-7 kb. Each genomic segment has a VPg linked to its 5’end and a 3' poly(A) tract.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and mRNA.
RNA-1 and RNA-2 are translated into two polyproteins, which are then processed into functional proteins. RNA-1 encodes proteins necessary for replication, while RNA-2 encodes one or two capsid proteins and product(s) involved in cell-to-cell movement.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. Synthesis and proteolytic cleavage of the replicase polyprotein RNA-1.
  4. Replication occurs in viral factories made of membrane vesicles derived from the ER. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Assembly of new virus particles.
  7. Movement protein allows cell-to-cell movement.

Matching UniProtKB/Swiss-Prot entries

42 entries grouped by protein (browse by keywords)

All proteins are shown (view only 31 complete proteome entries)

1 entry

Capsid protein (Coat protein)

CAPSD_TRSV
Tobacco ringspot virus (TobRV) (TRSV)

15 entries

RNA1 polyprotein (P1)

Select_allDeselect_all
POL1_BBWVS
Broad bean wilt virus 1 (strain Spinach/United States/ATCC PV-132/1963) (BBWV-1) reference strain

RNA1 polyprotein (Genome polyprotein B)

POL1_CPMVS
Cowpea mosaic virus (strain SB) (CPMV) reference strain

RNA1 polyprotein (Genome polyprotein B) (P1)

POL1_TORVR
Tomato ringspot virus (isolate raspberry) (ToRSV) reference strain
POL1_ARMVN
Arabis mosaic virus (isolate NW) (ArMV)
POL1_BPMV
Bean-pod mottle virus (strain Kentucky G7) (BPMV)

RNA1 polyprotein (Genome polyprotein B) (P1)

POL1_BRAV
Blackcurrant reversion association virus (BRAV)
POL1_BRSV
Beet ringspot virus (BRSV) (Tomato black ring virus (strain S))
POL1_CNSV
Cycas necrotic stunt virus (CNSV)
POL1_CPSMV
Cowpea severe mosaic virus (strain DG) (CPSMV)

RNA1 polyprotein (Genome polyprotein B) (P1)

POL1_GCMV
Grapevine chrome mosaic virus (GCMV) (Hungarian grapevine chrome mosaic virus)
POL1_GFLV
Grapevine fanleaf virus (GFLV)
POL1_RCMV
Red clover mottle virus (RCMV)

RNA1 polyprotein (Genome polyprotein B) (P1)

POL1_RRVC
Raspberry ringspot virus (strain cherry) (RpRSV)
POL1_TBRVM
Tomato black ring virus (strain MJ) (TBRV)
POL1_TRSVB
Tobacco ringspot virus (strain Bud Blight) (TobRV) (TRSV)

18 entries

RNA2 polyprotein (P2)

Select_allDeselect_all
POL2_BBWVS
Broad bean wilt virus 1 (strain Spinach/United States/ATCC PV-132/1963) (BBWV-1) reference strain

RNA2 polyprotein (Genome polyprotein M)

POL2_CPMVS
Cowpea mosaic virus (strain SB) (CPMV) reference strain

RNA2 polyprotein (Genome polyprotein M) (P2)

POL2_TORVR
Tomato ringspot virus (isolate raspberry) (ToRSV) reference strain
POL2_APMV
Andean potato mottle virus (APMV)

RNA2 polyprotein (Genome polyprotein M) (P2)

POL2_ARMVN
Arabis mosaic virus (isolate NW) (ArMV)
POL2_ARMVS
Arabis mosaic virus (isolate Syrah) (ArMV)
POL2_BPMV
Bean-pod mottle virus (strain Kentucky G7) (BPMV)

RNA2 polyprotein (Genome polyprotein M) (P2)

POL2_BRAV
Blackcurrant reversion association virus (BRAV)
POL2_BRSV
Beet ringspot virus (BRSV) (Tomato black ring virus (strain S))
POL2_CNSV
Cycas necrotic stunt virus (CNSV)
POL2_CPSMV
Cowpea severe mosaic virus (strain DG) (CPSMV)

RNA2 polyprotein (Genome polyprotein M) (P2)

POL2_GCMV
Grapevine chrome mosaic virus (GCMV) (Hungarian grapevine chrome mosaic virus)
POL2_GFLV
Grapevine fanleaf virus (GFLV)
POL2_GFLVN
Grapevine fanleaf virus (isolate NW) (GFLV)
POL2_RCMV
Red clover mottle virus (RCMV)

RNA2 polyprotein (Genome polyprotein M) (P2)

POL2_RRVC
Raspberry ringspot virus (strain cherry) (RpRSV)
POL2_RRVS
Raspberry ringspot virus (strain S) (RpRSV)
POL2_TRSV
Tobacco ringspot virus (TobRV) (TRSV)

2 entries

Protein P3

Select_allDeselect_all
VP3_ARMV
Arabis mosaic virus (ArMV)
VP3_GFLV
Grapevine fanleaf virus (GFLV)

4 entries

Satellite RNA 48 kDa protein

Select_allDeselect_all
VS48_BRSV
Beet ringspot virus (BRSV) (Tomato black ring virus (strain S))
VS48_TBRVC
Tomato black ring virus (strain C) (TBRV)
VS48_TBRVE
Tomato black ring virus (strain E) (TBRV)
VS48_TBRVL
Tomato black ring virus (strain L) (TBRV)

1 entry

Uncharacterized protein in RNA2

YR21_TORVR
Tomato ringspot virus (isolate raspberry) (ToRSV) reference strain

1 entry

Uncharacterized protein in RNA2

YR22_TORVR
Tomato ringspot virus (isolate raspberry) (ToRSV) reference strain