Alphaflexiviridae

VIRION

Non-enveloped, flexuous, filamentous, 470-800 nm or more long and 12-13 nm in diameter.

GENOME

Linear ssRNA(+) genome of 5.4-9 kb in size. The 3' terminus is polyadenylated and, in some genera, the 5' end is capped. Encodes 1 to 6 proteins.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. RNA-dependent RNA polymerase (RdRp) is translated directly from the genomic RNA. The other ORFS, when present, are transcribed presumably as monocistronic subgenomic mRNAs (sgRNAs). TGB3 is expressed by leaky scanning of the TGB2 subgenomic mRNA.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA is translated as a monocistronic mRNA to produce the RdRp (encoded by the 5'-proximal ORF).
  4. Replication occurs in viral factories recruited by TGB1. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Internal subgenomic promoters are used to transcribe the sgRNAs. Traduction of these sgRNAs yields the capsid and movement proteins.
  7. Assembly of new virus particles.
  8. Triple gene block proteins (TGBp) allow cell-to-cell and long-distance movement.

Host-virus interaction

Suppression of RNA silencing

Potato virus X TGBp1 protein functions as a suppressor of RNA silencing inhibiting the PTGS pathway .

Matching UniProtKB/Swiss-Prot entries

82 entries grouped by strain (browse by keywords)

Only complete proteome entries are shown (view all 95 entries)

7 entries

Papaya mosaic potexvirus (PMV) reference strain

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CAPSD_PMV Coat protein (Capsid protein) (CP)
RDRP_PMV RNA replication protein (176 kDa protein) (ORF1 protein) [Includes: RNA-directed RNA polymerase (EC ...
TGB1_PMV Movement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor P25) (Triple gene block ...
TGB3_PMV Movement protein TGBp3 (7 kDa protein) (Triple gene block 3 protein) (TGBp3)
TGB2_PMV Movement protein TGB2 (12 kDa protein) (Triple gene block 2 protein) (TGBp2)
Y14K_PMV Uncharacterized 14.1 kDa protein in ORF1 coding strand
Y15K_PMV Uncharacterized 14.7 kDa protein in coat protein coding strand

6 entries

Indian citrus ringspot virus (isolate Kinnow mandarin/India/K1/1996) (ICRSV) reference strain

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CAPSD_ICRSV Capsid protein (CP) (Coat protein)
RDRP_ICRSV RNA replication protein [Includes: RNA-directed RNA polymerase (EC 2.7.7.48); Helicase (EC ...
TGB1_ICRSV Movement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor P25) (Triple gene block ...
TGB2_ICRSV Movement protein TGB2 (Triple gene block 2 protein) (TGBp2)
TGB3_ICRSV Movement protein TGBp3 (Triple gene block 3 protein) (TGBp3)
VNBP_ICRSV 23kDa protein (Putative 23 kDa nucleic acid binding protein)

6 entries

Lolium latent virus (isolate Lolium/USA/US1/-) (LoLV) reference strain

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CAPSD_LOLV Capsid protein (CP) (Coat protein)
ORF6_LOLV Uncharacterized ORF6 protein
RDRP_LOLV RNA-directed RNA polymerase (EC 2.7.7.48) [Includes: Helicase (EC 3.6.4.13)]
TGB1_LOLV Movement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor P25) (Triple gene block ...
TGB3_LOLV Movement protein TGBp3 (Triple gene block 3 protein) (TGBp3)
TGB2_LOLV Movement protein TGB2 (14 kDa protein) (Triple gene block 2 protein) (TGBp2)

6 entries

Narcissus mosaic virus (NMV) reference strain

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CAPSD_NMV Coat protein (Capsid protein) (CP)
RDRP_NMV RNA replication protein (186 kDa protein) (ORF1 protein) [Includes: RNA-directed RNA polymerase (EC ...
TGB3_NMV Movement protein TGBp3 (7 kDa protein) (Triple gene block 3 protein) (TGBp3)
TGB1_NMV Movement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor P25) (Triple gene block ...
TGB2_NMV Movement protein TGB2 (14 kDa protein) (Triple gene block 2 protein) (TGBp2)
YOR6_NMV Uncharacterized 10 kDa protein (ORF 6)

6 entries

Shallot virus X (ShVX) reference strain

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CAPSD_SHVX Capsid protein (CP) (Coat protein)
ORF4_SHVX Uncharacterized ORF4 protein (42 kDa protein)
RDRP_SHVX RNA replication protein (194 kDa protein) [Includes: RNA-directed RNA polymerase (EC 2.7.7.48); ...
TGB1_SHVX Movement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor P25) (Triple gene block ...
TGB2_SHVX Movement protein TGB2 (12 kDa protein) (Triple gene block 2 protein) (TGBp2)
VNBP_SHVX 14.7 kDa protein (Putative nucleic acid-binding protein)

5 entries

Botrytis virus X (isolate Botrytis cinerea/New Zealand/Howitt/2006) (BOTV-X) reference strain

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CAPSD_BOTVX Capsid protein (CP)
ORF5_BOTVX Uncharacterized ORF5 protein
ORF2_BOTVX Uncharacterized ORF2 protein
ORF4_BOTVX Uncharacterized ORF4 protein
RDRP_BOTVX RNA replication protein [Includes: RNA-directed RNA polymerase (EC 2.7.7.48); Helicase (EC ...

5 entries

Foxtail mosaic virus reference strain

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CAPSD_FXMV Coat protein (Capsid protein) (CP)
RDRP_FXMV RNA replication protein (152 kDa protein) (ORF1 protein) [Includes: RNA-directed RNA polymerase (EC ...
TGB3_FXMV Movement protein TGBp3 (7 kDa protein) (Triple gene block 3 protein) (TGBp3)
TGB2_FXMV Movement protein TGB2 (12 kDa protein) (Triple gene block 2 protein) (TGBp2)
TGB1_FXMV Movement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor P25) (Triple gene block ...

5 entries

Plantago asiatica mosaic potexvirus (P1AMV) reference strain

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CAPSD_P1AMV Coat protein (Capsid protein) (CP)
RDRP_P1AMV RNA replication protein (156 kDa protein) (ORF1 protein) [Includes: RNA-directed RNA polymerase (EC ...
TGB1_P1AMV Movement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor P25) (Triple gene block ...
TGB3_P1AMV Movement protein TGBp3 (13 kDa protein) (Triple gene block 3 protein) (TGBp3)
TGB2_P1AMV Movement protein TGB2 (12 kDa protein) (Triple gene block 2 protein) (TGBp2)

5 entries

Potato virus X (strain X3) (PVX) reference strain

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CAPSD_PVXX3 Coat protein (Capsid protein) (CP)
RDRP_PVXX3 RNA replication protein (165 kDa protein) (ORF1 protein) [Includes: RNA-directed RNA polymerase (EC ...
TGB3_PVXX3 Movement protein TGBp3 (7 kDa protein) (Triple gene block 3 protein) (TGBp3)
TGB2_PVXX3 Movement protein TGB2 (12 kDa protein) (Triple gene block 2 protein) (TGBp2)
TGB1_PVXX3 Movement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor P25) (Triple gene block ...

5 entries

Strawberry mild yellow edge-associated virus (SMYEaV) reference strain

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CAPSD_SMYEA Coat protein (Capsid protein) (CP)
RDRP_SMYEA RNA replication protein (150 kDa protein) (ORF1 protein) [Includes: RNA-directed RNA polymerase (EC ...
TGB1_SMYEA Movement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor P25) (Triple gene block ...
TGB2_SMYEA Movement protein TGB2 (12 kDa protein) (Triple gene block 2 protein) (TGBp2)
TGB3_SMYEA Movement protein TGBp3 (8.1 kDa protein) (Triple gene block 3 protein) (TGBp3)

5 entries

White clover mosaic virus (strain M) (WCMV) reference strain

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CAPSD_WCMVM Coat protein (Capsid protein) (CP)
RDRP_WCMVM RNA replication protein (147 kDa protein) (ORF1 protein) [Includes: RNA-directed RNA polymerase (EC ...
TGB3_WCMVM Movement protein TGBp3 (7 kDa protein) (Triple gene block 3 protein) (TGBp3)
TGB1_WCMVM Movement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor P25) (Triple gene block ...
TGB2_WCMVM Movement protein TGB2 (13 kDa protein) (Triple gene block 2 protein) (TGBp2)

1 entry

Sclerotinia sclerotiorum debilitation-associated virus (isolate Sclerotinia/China/Xie/-) (SsDRV) reference strain

RDRP_SSDRV RNA replication protein [Includes: RNA-directed RNA polymerase (EC 2.7.7.48); Helicase (EC ...

5 entries

Potato virus X (PVX)

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CAPSD_PVX Coat protein (Capsid protein) (CP)
RDRP_PVX RNA replication protein (165 kDa protein) (ORF1 protein) [Includes: RNA-directed RNA polymerase (EC ...
TGB2_PVX Movement protein TGB2 (12 kDa protein) (Triple gene block 2 protein) (TGBp2)
TGB3_PVX Movement protein TGBp3 (7 kDa protein) (Triple gene block 3 protein) (TGBp3)
TGB1_PVX Movement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor P25) (Triple gene block ...

5 entries

Potato virus X (strain CP) (PVX)

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CAPSD_PVXCP Coat protein (Capsid protein) (CP)
RDRP_PVXCP RNA replication protein (165 kDa protein) (ORF1 protein) [Includes: RNA-directed RNA polymerase (EC ...
TGB1_PVXCP Movement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor P25) (Triple gene block ...
TGB3_PVXCP Movement protein TGBp3 (7 kDa protein) (Triple gene block 3 protein) (TGBp3)
TGB2_PVXCP Movement protein TGB2 (12 kDa protein) (Triple gene block 2 protein) (TGBp2)

5 entries

Potato virus X (strain HB) (PVX)

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CAPSD_PVXHB Coat protein (Capsid protein) (CP)
RDRP_PVXHB RNA replication protein (165 kDa protein) (ORF1 protein) [Includes: RNA-directed RNA polymerase (EC ...
TGB1_PVXHB Movement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor P25) (Triple gene block ...
TGB3_PVXHB Movement protein TGBp3 (9.7 kDa protein) (Triple gene block 3 protein) (TGBp3)
TGB2_PVXHB Movement protein TGB2 (12 kDa protein) (Triple gene block 2 protein) (TGBp2)

5 entries

White clover mosaic virus (strain O) (WCMV)

Select_allDeselect_all
CAPSD_WCMVO Coat protein (Capsid protein) (CP)
RDRP_WCMVO RNA replication protein (147 kDa protein) (ORF1 protein) [Includes: RNA-directed RNA polymerase (EC ...
TGB2_WCMVO Movement protein TGB2 (13 kDa protein) (Triple gene block 2 protein) (TGBp2)
TGB3_WCMVO Movement protein TGBp3 (7 kDa protein) (Triple gene block 3 protein) (TGBp3)
TGB1_WCMVO Movement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor P25) (Triple gene block ...