Picobirnaviridae

VIRION

Non enveloped, capsid with T=2* icosahedral symmetry, 35-40 nm in diameter .

GENOME

Segmented linear dsRNA genome: 2 segments encode for 4 proteins. Segments size range from 1.7 to 2.5 kb. Genome total size is about 4 kb.

GENE EXPRESSION

Genomic segment A encodes for a polyprotein (ORF1) that self-cleaves to yield the mature coat protein and a large peptide. Also encodes another protein (ORF2).
Genomic segment B encodes for the RNA-dependent RNA polymerase.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the cytoplasm.
  2. Transcription of the dsRNA genome by viral polymerase occurs inside the virion, so that dsRNA is never exposed to the cytoplasm. This plus-strand transcript is used as template for translation.
  3. (+)RNAs are encapsidated in virion particle, inside which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
  4. Mature virions are released by budding.

Matching UniProtKB/Swiss-Prot entries

3 entries grouped by strain (browse by keywords)

3 entries

Human picobirnavirus (strain Human/Thailand/Hy005102/-) (PBV) reference strain

Select_allDeselect_all
CAPSD_HPBVH Capsid protein precursor [Cleaved into: 7 kDa polypeptide; Capsid protein (CP)]
ORF1_HPBVH Uncharacterized ORF1 protein
RDRP_HPBVH Potential RNA-dependent RNA polymerase (EC 2.7.7.48)