Ephemerovirus

VIRION

Enveloped, bullet shaped. 180 nm long and 75 nm wide.

GENOME

Negative-stranded RNA linear genome, about 14.6-14.8 kb in size. Encodes for 5 to 9 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Matching UniProtKB/Swiss-Prot entries

18 entries grouped by strain (browse by keywords)

All proteins are shown (view only 12 complete proteome entries)

12 entries

Bovine ephemeral fever virus (strain BB7721) (BEFV) reference strain

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GLYCO_BEFVB Glycoprotein
L_BEFVB RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_BEFVB Matrix protein
NCAP_BEFVB Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_BEFVB Phosphoprotein (Protein P) (Protein M1)
VGLN_BEFVB Non-structural glycoprotein GNS
VPA3_BEFVB Protein alpha-3
VPG_BEFVB Protein gamma
VPP_BEFVB Putative protein P'
VPA1_BEFVB Protein alpha-1
VPB_BEFVB Protein beta
VPA2_BEFVB Protein alpha-2

6 entries

Adelaide River virus (ARV)

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GLYCO_ARV Glycoprotein
NCAP_ARV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
VPA2_ARV Protein alpha-2
VPB_ARV Protein beta
VGLN_ARV Non-structural glycoprotein
VPA1_ARV Protein alpha-1