Betacoronavirus

VIRION

Enveloped, spherical, about 120 nm in diameter. The RNA genome is associated with the N protein to form the nucleocapsid. see Neuman BW et al. for virion cryo-electron microscopy analysis.

GENOME

Monopartite, linear ssRNA(+) genome of 27-32kb in size (the largest of all RNA virus genomes). Capped, and polyadenylated. The leader RNA (65-89 bp) at the 5' end of the genome is also present at the end of each subgenomic RNAs.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. Genomic RNA encodes ORF1a, as for ORF1b, it is translated by ribosomal frameshifting. Resulting polyproteins pp1a and pp1ab are processed into the viral polymerase (RdRp) and other non-structural proteins involved in RNA synthesis. Structural proteins are expressed as subgenomic RNAs. Each RNA (genomic and subgenomic) is translated to yield only the protein encoded by the 5'-most ORF.

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral S protein (maybe also HE if present) to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the endosomal membrane (probably mediated by S2), ssRNA(+) genome is released into the cytoplasm.
  3. Synthesis and proteolytic cleavage of the replicase polyprotein.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Synthesis of structural proteins encoded by subgenomic mRNAs.
  7. Assembly and budding at membranes of the endoplasmic reticulum (ER), the intermediate compartments, and/or the Golgi complex.
  8. Release of new virions by exocytosis.

Host-virus interaction

Host gene expression shutoff

SARS-CoV nsp1 protein mediates host mRNA decay .

Apoptosis modulation

Human coronavirus induces neuronal apoptosis via mitochondrial apoptosis-inducing factor and cyclophilin D .

Cell-cycle modulation

SARS-CoV Nsp15 has a retinoblastoma protein-binding motif (LXCXE/D) and seems to interact with host retinoblastoma protein resulting in an increased proportion of cells in the S phase of the cell cycle. This probably involves G1/S host cell cycle checkpoint dysregulation by the virus .

Murine coronavirus and SARS-CoV may also induce G0/G1 checkpoint dysregulation .

Innate immune response inhibition

SARS-CoV Protein 3a, which has a viral channel activity, may cause endoplasmic reticulum stress and inhibition of the type 1 interferon receptor .

SARS-CoV PL-Pro mediates ISG15 inhibition and inhibition of host IRF3 .

SARS-CoV M protein mediates the inhibition of host TRAF3

Matching UniProtKB/Swiss-Prot entries

300 entries grouped by strain (browse by keywords)

All proteins are shown (view only 228 complete proteome entries)

15 entries

Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain

Select_allDeselect_all
AP3A_CVHSA Protein 3a (Accessory protein 3a) (Protein U274) (Protein X1)
NCAP_CVHSA Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS3B_CVHSA Non-structural protein 3b (ns3b) (Accessory protein 3b) (Protein X2)
NS7B_CVHSA Protein non-structural 7b (ns7b) (Accessory protein 7b)
NS6_CVHSA Non-structural protein 6 (ns6) (Accessory protein 6) (Protein X3)
NS7A_CVHSA Protein 7a (Accessory protein 7a) (Protein U122) (Protein X4)
NS8B_CVHSA Non-structural protein 8b (ns8b) (Accessory protein 8b)
NS8A_CVHSA Protein non-structural 8a (ns8a) (Accessory protein 8a)
ORF9B_CVHSA Protein 9b (Accessory protein 9b) (ORF-9b)
R1A_CVHSA Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_CVHSA Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
SPIKE_CVHSA Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike ...
VEMP_CVHSA Envelope small membrane protein (E protein) (sM protein)
VME1_CVHSA Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
Y14_CVHSA Uncharacterized protein 14

11 entries

Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain

Select_allDeselect_all
HEMA_CVMA5 Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVMA5 Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in nucleocapsid ORF)
NCAP_CVMA5 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS4_CVMA5 Non-structural protein 4 (ns4) (Accessory protein 4)
NS12_CVMA5 Non-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS2A_CVMA5 Non-structural protein 2a (ns2a) (30 kDa accessory protein) (30 kDa non-structural protein) (ns2) ...
R1A_CVMA5 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_CVMA5 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
SPIKE_CVMA5 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1 (90B); ...
VEMP_CVMA5 Envelope small membrane protein (E protein) (sM protein) (Non-structural protein NS3)
VME1_CVMA5 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

10 entries

Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain

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NCAP_BCHK4 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS3A_BCHK4 Non-structural protein 3a (ns3a) (Accessory protein 3a)
NS3B_BCHK4 Non-structural protein 3b (ns3b) (Accessory protein 3b)
NS3D_BCHK4 Non-structural protein 3d (ns3d) (Accessory protein 3d)
ORF4B_BCHK4 Non-structural protein ORF4b (ORF4b)
R1AB_BCHK4 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
R1A_BCHK4 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
SPIKE_BCHK4 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike ...
VEMP_BCHK4 Envelope small membrane protein (E protein) (sM protein)
VME1_BCHK4 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

10 entries

Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain

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ORF4B_BCHK5 Non-structural protein ORF4b (ORF4b)
NCAP_BCHK5 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS3A_BCHK5 Non-structural protein 3a (ns3a) (Accessory protein 3a)
NS3B_BCHK5 Non-structural protein 3b (ns3b) (Accessory protein 3b)
NS3D_BCHK5 Non-structural protein 3d (ns3d) (Accessory protein 3d)
R1AB_BCHK5 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
R1A_BCHK5 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
SPIKE_BCHK5 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike ...
VEMP_BCHK5 Envelope small membrane protein (E protein) (sM protein)
VME1_BCHK5 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

10 entries

Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain

Select_allDeselect_all
ORF3_CVEMC Non-structural protein ORF3 (ORF3)
ORF4B_CVEMC Non-structural protein ORF4b (ORF4b)
NCAP_CVEMC Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
ORF5_CVEMC Non-structural protein ORF5 (ORF5)
ORF4A_CVEMC Non-structural protein ORF4a (ORF4a)
R1AB_CVEMC Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
R1A_CVEMC Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Host translation inhibitor nsp1 ...
SPIKE_CVEMC Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1 (90B); ...
VME1_CVEMC Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
VEMP_CVEMC Envelope small membrane protein (E protein) (sM protein)

4 entries

Human coronavirus OC43 (HCoV-OC43) reference strain

Select_allDeselect_all
IORF_CVHOC Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in nucleocapsid ORF)
NS2A_CVHOC Non-structural protein 2a (ns2a) (32 kDa accessory protein) (32 kDa non-structural protein) (ns2)
R1A_CVHOC Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_CVHOC Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

9 entries

Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain

Select_allDeselect_all
NCAP_BCHK9 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS3_BCHK9 Non-structural protein 3 (ns3) (Accessory protein 3)
NS7A_BCHK9 Non-structural protein 7a (ns7a) (Accessory protein 7a)
NS7B_BCHK9 Non-structural protein 7b (ns7b) (Accessory protein 7b)
R1AB_BCHK9 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
R1A_BCHK9 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
VME1_BCHK9 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
SPIKE_BCHK9 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike ...
VEMP_BCHK9 Envelope small membrane protein (E protein) (sM protein)

9 entries

Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain

Select_allDeselect_all
HEMA_CVHN1 Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVHN1 Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Orf8 protein) (Protein in ...
NCAP_CVHN1 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVHN1 Non-structural protein 4 (ns4) (Accessory protein 4) (Non-structural protein of 12.5 kDa) (ns12.5) ...
R1AB_CVHN1 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
R1A_CVHN1 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
VME1_CVHN1 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
SPIKE_CVHN1 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike ...
VEMP_CVHN1 Envelope small membrane protein (E protein) (sM protein)

8 entries

Porcine hemagglutinating encephalomyelitis virus (strain 67N) (HEV-67N) reference strain

Select_allDeselect_all
HEMA_CVP67 Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVP67 Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in nucleocapsid ORF)
NCAP_CVP67 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS49_CVP67 Truncated non-structural protein of 4.9 kDa (Truncated ns4.9) (Truncated 4.9 kDa accessory protein)
NS12_CVP67 Non-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
SPIKE_CVP67 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1 (90B); ...
VEMP_CVP67 Envelope small membrane protein (E protein) (sM protein)
VME1_CVP67 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

4 entries

Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain

Select_allDeselect_all
NCAP_CVM2 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
R1AB_CVM2 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
R1A_CVM2 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
VME1_CVM2 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

13 entries

Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)

Select_allDeselect_all
AP3A_BCRP3 Protein 3 (Accessory protein 3)
NCAP_BCRP3 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS8_BCRP3 Non-structural protein 8 (ns8) (Accessory protein 8)
NS6_BCRP3 Non-structural protein 6 (ns6) (Accessory protein 6)
NS7A_BCRP3 Protein 7a (Accessory protein 7a)
NS7B_BCRP3 Non-structural protein 7b (ns7b) (Accessory protein 7b)
ORF9B_BCRP3 Protein 9b (Accessory protein 9b) (ORF-9b)
R1AB_BCRP3 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
R1A_BCRP3 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
VME1_BCRP3 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
SPIKE_BCRP3 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike ...
VEMP_BCRP3 Envelope small membrane protein (E protein) (sM protein)
Y14_BCRP3 Uncharacterized protein 14

12 entries

Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)

Select_allDeselect_all
AP3A_BC279 Protein 3 (Accessory protein 3)
ORF9B_BC279 Protein 9b (Accessory protein 9b) (ORF-9b)
NCAP_BC279 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS7B_BC279 Non-structural protein 7b (ns7b) (Accessory protein 7b)
NS8_BC279 Non-structural protein 8 (ns8) (Accessory protein 8)
NS6_BC279 Non-structural protein 6 (ns6) (Accessory protein 6)
NS7A_BC279 Protein 7a (Accessory protein 7a)
R1AB_BC279 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
R1A_BC279 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
VME1_BC279 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
SPIKE_BC279 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike ...
VEMP_BC279 Envelope small membrane protein (E protein) (sM protein)

12 entries

Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)

Select_allDeselect_all
AP3A_BCHK3 Protein 3 (Accessory protein 3)
ORF9B_BCHK3 Protein 9b (Accessory protein 9b) (ORF-9b)
NCAP_BCHK3 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS7A_BCHK3 Protein 7a (Accessory protein 7a)
NS6_BCHK3 Non-structural protein 6 (ns6) (Accessory protein 6)
NS8_BCHK3 Non-structural protein 8 (ns8) (Accessory protein 8)
NS7B_BCHK3 Non-structural protein 7b (ns7b) (Accessory protein 7b)
R1AB_BCHK3 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
R1A_BCHK3 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
SPIKE_BCHK3 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike ...
VME1_BCHK3 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
VEMP_BCHK3 Envelope small membrane protein (E protein) (sM protein)

12 entries

Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)

Select_allDeselect_all
HEMA_CVBEN Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVBEN Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in nucleocapsid ORF)
NCAP_CVBEN Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVBEN Non-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS2A_CVBEN Non-structural protein 2a (ns2a) (32 kDa accessory protein) (32 kDa non-structural protein) (ns2)
NS48_CVBEN Non-structural protein of 4.8 kDa (ns4.8) (4.8 kDa accessory protein)
NS49_CVBEN Truncated non-structural protein of 4.9 kDa (Truncated ns4.9) (Truncated 4.9 kDa accessory protein)
R1A_CVBEN Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_CVBEN Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
SPIKE_CVBEN Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1 (90B); ...
VME1_CVBEN Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
VEMP_CVBEN Envelope small membrane protein (E protein) (sM protein)

12 entries

Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)

Select_allDeselect_all
HEMA_CVBLU Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVBLU Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in nucleocapsid ORF)
NCAP_CVBLU Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS49_CVBLU Truncated non-structural protein of 4.9 kDa (Truncated ns4.9) (Truncated 4.9 kDa accessory protein)
NS48_CVBLU Non-structural protein of 4.8 kDa (ns4.8) (4.8 kDa accessory protein)
NS12_CVBLU Non-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS2A_CVBLU Non-structural protein 2a (ns2a) (32 kDa accessory protein) (32 kDa non-structural protein) (ns2)
R1A_CVBLU Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_CVBLU Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
VME1_CVBLU Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
SPIKE_CVBLU Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1 (90B); ...
VEMP_CVBLU Envelope small membrane protein (E protein) (sM protein)

12 entries

Bovine coronavirus (strain Mebus) (BCoV) (BCV)

Select_allDeselect_all
HEMA_CVBM Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVBM Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in nucleocapsid ORF)
NCAP_CVBM Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS49_CVBM Non-structural protein of 4.9 kDa (ns4.9) (4.9 kDa accessory protein)
NS2A_CVBM Non-structural protein 2a (ns2a) (32 kDa accessory protein) (32 kDa non-structural protein) (ns2)
NS48_CVBM Non-structural protein of 4.8 kDa (ns4.8) (4.8 kDa accessory protein)
NS12_CVBM Non-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
R1AB_CVBM Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
R1A_CVBM Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
VME1_CVBM Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
SPIKE_CVBM Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1 (90B); ...
VEMP_CVBM Envelope small membrane protein (E protein) (sM protein)

12 entries

Bovine coronavirus (strain Quebec) (BCoV) (BCV)

Select_allDeselect_all
HEMA_CVBQ Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVBQ Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in nucleocapsid ORF)
NCAP_CVBQ Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS2A_CVBQ Non-structural protein 2a (ns2a) (32 kDa accessory protein) (32 kDa non-structural protein) (ns2)
NS48_CVBQ Non-structural protein of 4.8 kDa (ns4.8) (4.8 kDa accessory protein)
NS12_CVBQ Non-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS49_CVBQ Non-structural protein of 4.9 kDa (ns4.9) (4.9 kDa accessory protein)
R1A_CVBQ Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_CVBQ Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
SPIKE_CVBQ Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1 (90B); ...
VEMP_CVBQ Envelope small membrane protein (E protein) (sM protein)
VME1_CVBQ Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

11 entries

Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)

Select_allDeselect_all
HEMA_CVMJH Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVMJH Protein I (N internal ORF protein) (IORF) (N2 protein) (Protein in nucleocapsid ORF)
NCAP_CVMJH Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVMJH Non-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS2A_CVMJH Non-structural protein 2a (ns2a) (30 kDa accessory protein) (30 kDa non-structural protein) (ns2) ...
NS4_CVMJH Non-structural protein 4 (ns4) (Accessory protein 4)
R1A_CVMJH Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_CVMJH Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
VME1_CVMJH Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
SPIKE_CVMJH Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1 (90B); ...
VEMP_CVMJH Envelope small membrane protein (E protein) (sM protein)

10 entries

Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)

Select_allDeselect_all
NCAP_BC133 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS3C_BC133 Non-structural protein 3c (ns3c) (Accessory protein 3c)
NS3B_BC133 Non-structural protein 3b (ns3b) (Accessory protein 3b)
NS3D_BC133 Non-structural protein 3d (ns3d) (Accessory protein 3d)
NS3A_BC133 Non-structural protein 3a (ns3a) (Accessory protein 3a)
R1A_BC133 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_BC133 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
VME1_BC133 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
SPIKE_BC133 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike ...
VEMP_BC133 Envelope small membrane protein (E protein) (sM protein)

10 entries

Bovine coronavirus (strain LSU-94LSS-051) (BCoV-LSU) (BCV)

Select_allDeselect_all
HEMA_CVBLS Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVBLS Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in nucleocapsid ORF)
NCAP_CVBLS Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVBLS Non-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS2A_CVBLS Non-structural protein 2a (ns2a) (32 kDa accessory protein) (32 kDa non-structural protein) (ns2)
NS48_CVBLS Non-structural protein of 4.8 kDa (ns4.8) (4.8 kDa accessory protein)
NS49_CVBLS Truncated non-structural protein of 4.9 kDa (Truncated ns4.9) (Truncated 4.9 kDa accessory protein)
VME1_CVBLS Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
SPIKE_CVBLS Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1 (90B); ...
VEMP_CVBLS Envelope small membrane protein (E protein) (sM protein)

10 entries

Bovine coronavirus (strain LY-138) (BCoV) (BCV)

Select_allDeselect_all
HEMA_CVBLY Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVBLY Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in nucleocapsid ORF)
NCAP_CVBLY Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS2A_CVBLY Non-structural protein 2a (ns2a) (32 kDa accessory protein) (32 kDa non-structural protein) (ns2)
NS48_CVBLY Non-structural protein of 4.8 kDa (ns4.8) (4.8 kDa accessory protein)
NS12_CVBLY Non-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS49_CVBLY Non-structural protein of 4.9 kDa (ns4.9) (4.9 kDa accessory protein)
SPIKE_CVBLY Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1 (90B); ...
VME1_CVBLY Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
VEMP_CVBLY Envelope small membrane protein (E protein) (sM protein)

10 entries

Bovine coronavirus (strain OK-0514) (BCoV) (BCV)

Select_allDeselect_all
HEMA_CVBOK Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVBOK Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in nucleocapsid ORF)
NCAP_CVBOK Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVBOK Non-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS48_CVBOK Non-structural protein of 4.8 kDa (ns4.8) (4.8 kDa accessory protein)
NS49_CVBOK Non-structural protein of 4.9 kDa (ns4.9) (4.9 kDa accessory protein)
NS2A_CVBOK Non-structural protein 2a (ns2a) (32 kDa accessory protein) (32 kDa non-structural protein) (ns2)
SPIKE_CVBOK Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1 (90B); ...
VME1_CVBOK Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
VEMP_CVBOK Envelope small membrane protein (E protein) (sM protein)

6 entries

Human coronavirus OC43 (HCoV-OC43)

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HEMA_CVHOC Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
NCAP_CVHOC Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVHOC Non-structural protein of 12.9 kDa (ns12.9) (12.9 kDa accessory protein) (NS2)
SPIKE_CVHOC Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1 (90B); ...
VME1_CVHOC Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
VEMP_CVHOC Envelope small membrane protein (E protein) (sM protein) (NS3 protein)

9 entries

Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)

Select_allDeselect_all
HEMA_CVHN2 Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVHN2 Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Orf8 protein) (Protein in ...
NCAP_CVHN2 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVHN2 Non-structural protein 4 (ns4) (Accessory protein 4) (Non-structural protein of 12.5 kDa) (ns12.5) ...
R1A_CVHN2 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_CVHN2 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
SPIKE_CVHN2 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike ...
VEMP_CVHN2 Envelope small membrane protein (E protein) (sM protein)
VME1_CVHN2 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

9 entries

Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)

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HEMA_CVHN5 Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVHN5 Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Orf8 protein) (Protein in ...
NCAP_CVHN5 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVHN5 Non-structural protein 4 (ns4) (Accessory protein 4) (Non-structural protein of 12.5 kDa) (ns12.5) ...
R1AB_CVHN5 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
R1A_CVHN5 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
SPIKE_CVHN5 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike ...
VEMP_CVHN5 Envelope small membrane protein (E protein) (sM protein)
VME1_CVHN5 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

9 entries

Rat coronavirus (strain 681) (RCV-SDAV) (Sialodacryoadenitis virus SDAV-681)

Select_allDeselect_all
HEMA_CVRSD Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVRSD Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in nucleocapsid ORF)
NCAP_CVRSD Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS4_CVRSD Non-structural protein 4 (15 kDa non-structural protein) (Accessory protein 4) (ns4)
NS12_CVRSD Non-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS2A_CVRSD Non-structural protein 2a (ns2a) (32 kDa accessory protein) (32 kDa non-structural protein) (ns2)
SPIKE_CVRSD Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1 (90B); ...
VME1_CVRSD Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
VEMP_CVRSD Envelope small membrane protein (E protein) (sM protein)

8 entries

Porcine hemagglutinating encephalomyelitis virus (strain IAF-404) (HEV)

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HEMA_CVPIA Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVPIA Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in nucleocapsid ORF)
NCAP_CVPIA Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVPIA Non-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS49_CVPIA Truncated non-structural protein of 4.9 kDa (Truncated ns4.9) (Truncated 4.9 kDa accessory protein)
SPIKE_CVPIA Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1 (90B); ...
VEMP_CVPIA Envelope small membrane protein (E protein) (sM protein)
VME1_CVPIA Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

7 entries

Bovine coronavirus (strain F15) (BCoV) (BCV)

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HEMA_CVBF Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVBF Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in nucleocapsid ORF)
NCAP_CVBF Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVBF Non-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
SPIKE_CVBF Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1 (90B); ...
VEMP_CVBF Envelope small membrane protein (E protein) (sM protein)
VME1_CVBF Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

5 entries

Bovine coronavirus (strain Ontario) (BCoV) (BCV)

Select_allDeselect_all
HEMA_CVBON Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
NS12_CVBON Non-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS49_CVBON Truncated non-structural protein of 4.9 kDa (Truncated ns4.9) (Truncated 4.9 kDa accessory protein)
NS48_CVBON Non-structural protein of 4.8 kDa (ns4.8) (4.8 kDa accessory protein)
VEMP_CVBON Envelope small membrane protein (E protein) (sM protein)

5 entries

Murine coronavirus (strain S) (MHV-S) (Murine hepatitis virus)

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HEMA_CVMS Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVMS Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in nucleocapsid ORF)
NCAP_CVMS Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS4_CVMS Non-structural protein 4 (ns4) (Accessory protein 4)
VEMP_CVMS Envelope small membrane protein (E protein) (sM protein)

2 entries

Bovine coronavirus (strain L9) (BCoV) (BCV)

Select_allDeselect_all
HEMA_CVBL9 Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
SPIKE_CVBL9 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1 (90B); ...

2 entries

Murine coronavirus (strain 1) (MHV-1) (Murine hepatitis virus)

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IORF_CVM1 Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in nucleocapsid ORF)
NCAP_CVM1 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

2 entries

Murine coronavirus (strain 3) (MHV-3) (Murine hepatitis virus)

Select_allDeselect_all
IORF_CVM3 Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in nucleocapsid ORF)
NCAP_CVM3 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

2 entries

Murine coronavirus (strain DVIM) (MHV-DVIM) (Murine hepatitis virus)

Select_allDeselect_all
HEMA_CVMDV Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
NCAP_CVMDV Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

2 entries

Puffinosis coronavirus (PV) (Puffinosis virus)

Select_allDeselect_all
HEMA_CVPV Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
NCAP_CVPV Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

1 entry

Bovine coronavirus (strain G95) (BCoV) (BCV)

HEMA_CVBG9 Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)

1 entry

Bovine coronavirus (strain vaccine) (BCoV) (BCV)

SPIKE_CVBV Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1 (90B); ...

1 entry

Equine coronavirus (isolate NC99) (ECoV)

NCAP_CVEN9 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

1 entry

Murine coronavirus (strain 4) (MHV-4) (Murine hepatitis virus)

SPIKE_CVM4 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1 (90B); ...

1 entry

Murine coronavirus (strain JHMV / variant CL-2) (MHV) (Murine hepatitis virus)

SPIKE_CVMJC Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1 (90B); ...

1 entry

Rat coronavirus (strain NJ) (RCV-NJ)

NCAP_CVRNJ Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)