Gammacoronavirus

VIRION

Enveloped, spherical, about 120 nm in diameter. The RNA genome is associated with the N protein to form the nucleocapsid. see Neuman BW et al. for virion cryo-electron microscopy analysis.

GENOME

Monopartite, linear ssRNA(+) genome of 27-32kb in size (the largest of all RNA virus genomes). Capped, and polyadenylated. The leader RNA (65-89 bp) at the 5' end of the genome is also present at the end of each subgenomic RNAs.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. Genomic RNA encodes for ORF1a, as for ORF1b, it is translated by ribosomal frameshifting. Resulting proteins pp1a and pp1ab are processed into the viral polymerase (RdRp) and other non-structural proteins involved in RNA synthesis. Structural proteins are expressed as subgenomic RNAs. Each RNA (genomic and subgenomic) is translated to yield only the protein encoded by the 5'-most ORF.

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral S protein (maybe also HE if present) to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the endosomal membrane (probably mediated by S2), ssRNA(+) genome is released into the cytoplasm.
  3. Synthesis and proteolytic cleavage of the replicase polyprotein.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Synthesis of structural proteins encoded by subgenomic mRNAs.
  7. Assembly and budding at membranes of the endoplasmic reticulum (ER), the intermediate compartments, and/or the Golgi complex.
  8. Release of new virions by exocytosis.

Host-virus interaction

Autophagy modulation

IBV nsp6 proteins induces autophagy to promote virus replication .

Apoptosis modulation

IBV seems to induce apoptosis at late stages of the infection cycle .

Cell-cycle modulation

IBV induces a both S-phase and G(2)/M-phase arrest in infected cells to promote favorable conditions for viral replication .

Matching UniProtKB/Swiss-Prot entries

64 entries grouped by strain (browse by keywords)

All proteins are shown (view only 24 complete proteome entries)

10 entries

Avian infectious bronchitis virus (strain Beaudette) (IBV) reference strain

Select_allDeselect_all
NS5A_IBVB Non-structural protein 5a (ns5a) (Accessory protein 5a)
NS5B_IBVB Non-structural protein 5b (ns5b) (Accessory protein 5b)
NS3A_IBVB Non-structural protein 3a (ns3a) (Accessory protein 3a)
NCAP_IBVB Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS3B_IBVB Non-structural protein 3b (ns3b) (Accessory protein 3b)
R1AB_IBVB Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 2 ...
R1A_IBVB Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 2 (nsp2) ...
SPIKE_IBVB Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike ...
VME1_IBVB Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
VEMP_IBVB Envelope small membrane protein (E protein) (sM protein) (3c protein)

10 entries

Avian infectious bronchitis virus (strain M41) (IBV)

Select_allDeselect_all
NS3B_IBVM Non-structural protein 3b (ns3b) (Accessory protein 3b)
NS5A_IBVM Non-structural protein 5a (ns5a) (Accessory protein 5a)
NS5B_IBVM Non-structural protein 5b (ns5b) (Accessory protein 5b)
NCAP_IBVM Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS3A_IBVM Non-structural protein 3a (ns3a) (Accessory protein 3a)
R1AB_IBVM Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 2 ...
R1A_IBVM Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 2 (nsp2) ...
SPIKE_IBVM Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike ...
VME1_IBVM Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
VEMP_IBVM Envelope small membrane protein (E protein) (sM protein) (3c protein)

5 entries

Avian infectious bronchitis virus (strain KB8523) (IBV)

Select_allDeselect_all
SPIKE_IBVK Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike ...
NCAP_IBVK Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS5B_IBVK Non-structural protein 5b (ns5b) (Accessory protein 5b)
VME1_IBVK Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
VEMP_IBVK Envelope small membrane protein (E protein) (sM protein) (3c protein)

4 entries

Avian infectious bronchitis virus (strain Beaudette CK) (IBV)

Select_allDeselect_all
NCAP_IBVBC Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
R1A_IBVBC Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 2 (nsp2) ...
R1AB_IBVBC Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 2 ...
VME1_IBVBC Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

3 entries

Avian infectious bronchitis virus (strain Portugal/322/82) (IBV)

Select_allDeselect_all
NS3B_IBVP3 Non-structural protein 3b (ns3b) (Accessory protein 3b)
NS3A_IBVP3 Non-structural protein 3a (ns3a) (Accessory protein 3a)
VEMP_IBVP3 Envelope small membrane protein (E protein) (sM protein) (3c protein)

3 entries

Avian infectious bronchitis virus (strain UK/183/66) (IBV)

Select_allDeselect_all
NS3B_IBVU5 Non-structural protein 3b (ns3b) (Accessory protein 3b)
NS3A_IBVU5 Non-structural protein 3a (ns3a) (Accessory protein 3a)
VEMP_IBVU5 Envelope small membrane protein (E protein) (sM protein) (3c protein)

3 entries

Avian infectious bronchitis virus (strain UK/68/84) (IBV)

Select_allDeselect_all
NS3A_IBVU4 Non-structural protein 3a (ns3a) (Accessory protein 3a)
NS3B_IBVU4 Non-structural protein 3b (ns3b) (Accessory protein 3b)
VEMP_IBVU4 Envelope small membrane protein (E protein) (sM protein) (3c protein)

2 entries

Avian infectious bronchitis virus (strain 6/82) (IBV)

Select_allDeselect_all
SPIKE_IBV6 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike ...
VME1_IBV6 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

2 entries

Avian infectious bronchitis virus (strain Beaudette US) (IBV)

Select_allDeselect_all
NCAP_IBVBU Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
VME1_IBVBU Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

2 entries

Avian infectious bronchitis virus (strain D1466) (IBV)

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NCAP_IBVD1 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
VME1_IBVD1 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

2 entries

Avian infectious bronchitis virus (strain DE072) (IBV)

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NCAP_IBVDE Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
VME1_IBVDE Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

2 entries

Avian infectious bronchitis virus (strain Gray) (IBV)

Select_allDeselect_all
NCAP_IBVG Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
VME1_IBVG Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

2 entries

Avian infectious bronchitis virus (strain H120) (IBV)

Select_allDeselect_all
NCAP_IBVH1 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
VME1_IBVH1 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

2 entries

Avian infectious bronchitis virus (strain H52) (IBV)

Select_allDeselect_all
NCAP_IBVH5 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
VME1_IBVH5 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

2 entries

Turkey enteric coronavirus (TCoV) (TCV)

Select_allDeselect_all
IORF_CVTKE Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in nucleocapsid ORF)
VME1_CVTKE Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

1 entry

Avian infectious bronchitis virus (strain Arkansas 99) (IBV)

NCAP_IBVAR Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

1 entry

Avian infectious bronchitis virus (strain Beaudette M42) (IBV)

VME1_IBVB2 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

1 entry

Avian infectious bronchitis virus (strain D274) (IBV)

SPIKE_IBVD2 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike ...

1 entry

Avian infectious bronchitis virus (strain D41) (IBV)

VME1_IBV41 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

1 entry

Avian infectious bronchitis virus (strain SAIB20) (IBV)

NCAP_IBVSA Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

1 entry

Avian infectious bronchitis virus (strain V18/91) (IBV)

NCAP_IBVV1 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

1 entry

Avian infectious bronchitis virus (strain Vic S) (IBV)

NCAP_IBVVI Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

1 entry

Turkey coronavirus (strain Indiana) (TCoV) (TCV)

NCAP_CVTIN Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

1 entry

Turkey coronavirus (strain Minnesota) (TCoV) (TCV)

NCAP_CVTMI Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

1 entry

Turkey coronavirus (strain NC95) (TCoV) (TCV)

NCAP_CVTNC Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)