Novirhabdovirus

VIRION

Enveloped, bullet shaped. 180 nm long and 75 nm wide.

GENOME

Negative-stranded RNA linear genome, about 11kb in size. Encodes for six proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription , viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Host-virus interaction

Inhibition of host apoptosis

The NV protein of VHSV has an antiapoptotic function at the early stage of the virus infection

Matching UniProtKB/Swiss-Prot entries

30 entries grouped by strain (browse by keywords)

All proteins are shown (view only 24 complete proteome entries)

6 entries

Infectious hematopoietic necrosis virus (strain WRAC) (IHNV) reference strain

Select_allDeselect_all
GLYCO_IHNVW Glycoprotein (Spike glycoprotein)
MATRX_IHNVW Matrix protein (Protein M2)
L_IHNVW RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_IHNVW Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
NV_IHNVW Non-virion protein
PHOSP_IHNVW Phosphoprotein (Protein P) (Protein M1)

6 entries

Snakehead rhabdovirus (SHRV) reference strain

Select_allDeselect_all
GLYCO_SHRV Glycoprotein
MATRX_SHRV Matrix protein
L_SHRV RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_SHRV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
NV_SHRV Non-virion protein
PHOSP_SHRV Phosphoprotein (Protein P) (Protein M1)

6 entries

Hirame rhabdovirus (strain Korea/CA 9703/1997) (HIRRV)

Select_allDeselect_all
GLYCO_HIRRV Glycoprotein
MATRX_HIRRV Matrix protein
L_HIRRV RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_HIRRV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
NV_HIRRV Non-virion protein
PHOSP_HIRRV Phosphoprotein (Protein P) (Protein M1)

6 entries

Infectious hematopoietic necrosis virus (strain Oregon69) (IHNV)

Select_allDeselect_all
GLYCO_IHNVO Glycoprotein (Spike glycoprotein)
L_IHNVO RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_IHNVO Matrix protein (Protein M2)
NCAP_IHNVO Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
NV_IHNVO Non-virion protein
PHOSP_IHNVO Phosphoprotein (Protein P) (Protein M1)

3 entries

Infectious hematopoietic necrosis virus (strain Round Butte) (IHNV)

Select_allDeselect_all
GLYCO_IHNVR Glycoprotein (Spike glycoprotein)
NCAP_IHNVR Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
NV_IHNVR Non-virion protein

2 entries

Viral hemorrhagic septicemia virus (strain 07-71) (VHSV)

Select_allDeselect_all
GLYCO_VHSV0 Spike glycoprotein
NCAP_VHSV0 Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

1 entry

Viral hemorrhagic septicemia virus (strain Makah) (VHSV)

NCAP_VHSVM Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)