Pneumoviridae

VIRION

Enveloped, spherical. Diameter from about 150nm nm.

GENOME

Negative-stranded RNA linear genome, about 13-15 kb in size. Encodes for 8 to 11 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The NS2 protein plays a role in inhibition of RIG-I antiviral signaling

The NS1 protein plays a role in inhibition of MAVS antiviral signaling

Activation of host NF-kappa-B

The HRSV M2-1 can activate NF-kappa-B signaling through interaction with host RELA.

Matching UniProtKB/Swiss-Prot entries

112 entries grouped by protein (browse by keywords)

All proteins are shown (view only 62 complete proteome entries)

12 entries

Fusion glycoprotein F0

Select_allDeselect_all
FUS_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain

Fusion glycoprotein F0 (Protein F)

FUS_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
FUS_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain

Fusion glycoprotein F0 (Protein F)

FUS_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain

Fusion glycoprotein F0 (Protein F)

FUS_BRSVC
Bovine respiratory syncytial virus (strain Copenhagen) (BRS)
FUS_BRSVR
Bovine respiratory syncytial virus (strain Rb94) (BRS)
FUS_HRSV1
Human respiratory syncytial virus B (strain 18537)
FUS_HRSVA
Human respiratory syncytial virus A (strain A2)

Fusion glycoprotein F0 (Protein F)

FUS_HRSVL
Human respiratory syncytial virus A (strain Long)
FUS_HRSVR
Human respiratory syncytial virus A (strain RSS-2)
FUS_MPV15
Murine pneumonia virus (strain 15) (MPV)
FUS_TRTV
Turkey rhinotracheitis virus (TRTV)

23 entries

Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

Select_allDeselect_all
GLYC_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
GLYC_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
GLYC_BRSV1
Bovine respiratory syncytial virus (strain 127) (BRS)
GLYC_BRSV2
Bovine respiratory syncytial virus (strain 220-60) (BRS)
GLYC_BRSV4
Bovine respiratory syncytial virus (strain 4642) (BRS)
GLYC_BRSV7
Bovine respiratory syncytial virus (strain 375) (BRS)
GLYC_BRSV9
Bovine respiratory syncytial virus (strain 220-69) (BRS)
GLYC_BRSVC
Bovine respiratory syncytial virus (strain Copenhagen) (BRS)
GLYC_BRSVL
Bovine respiratory syncytial virus (strain Lelystad) (BRS)
GLYC_BRSVR
Bovine respiratory syncytial virus (strain Rb94) (BRS)
GLYC_BRSVS
Bovine respiratory syncytial virus (strain Snook) (BRS)
GLYC_BRSVW
Bovine respiratory syncytial virus (strain Wbh) (BRS)
GLYC_HRSV1
Human respiratory syncytial virus B (strain 18537)
GLYC_HRSV2
Human respiratory syncytial virus A (strain rsb642)
GLYC_HRSV3
Human respiratory syncytial virus A (strain rsb1734)
GLYC_HRSV4
Human respiratory syncytial virus A (strain rsb5857)
GLYC_HRSV5
Human respiratory syncytial virus A (strain rsb6190)
GLYC_HRSV6
Human respiratory syncytial virus A (strain rsb6256)
GLYC_HRSV7
Human respiratory syncytial virus A (strain rsb6614)
GLYC_HRSV8
Human respiratory syncytial virus B (strain 8/60)

Major surface glycoprotein G (Attachment glycoprotein G)

GLYC_HRSVA
Human respiratory syncytial virus A (strain A2)
GLYC_HRSVL
Human respiratory syncytial virus A (strain Long)
GLYC_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

Major surface glycoprotein G (Attachment glycoprotein G)

7 entries

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

Select_allDeselect_all
L_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain
L_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
L_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain
L_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
L_MPV15
Murine pneumonia virus (strain 15) (MPV) reference strain
L_HRSVA
Human respiratory syncytial virus A (strain A2)
L_HRSVL
Human respiratory syncytial virus A (strain Long)

7 entries

Matrix M2-1 (Envelope-associated 22 kDa protein)

Select_allDeselect_all
M21_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain
M21_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
M21_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain
M21_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
M21_MPV15
Murine pneumonia virus (strain 15) (MPV) reference strain
M21_HRSVA
Human respiratory syncytial virus A (strain A2)
M21_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

5 entries

Matrix M2-2

Select_allDeselect_all
M22_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain
M22_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
M22_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain

Matrix protein M2-2

M22_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
M22_HRSVA
Human respiratory syncytial virus A (strain A2)

6 entries

Matrix protein

Select_allDeselect_all
MATRX_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
MATRX_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
MATRX_HRSS2
Human respiratory syncytial virus A (strain S-2) (HRSV-S2)
MATRX_HRSVA
Human respiratory syncytial virus A (strain A2)
MATRX_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)
MATRX_TRTV
Turkey rhinotracheitis virus (TRTV)

3 entries

Matrix protein

Select_allDeselect_all
MTRX_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain
MTRX_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain
MTRX_MPV15
Murine pneumonia virus (strain 15) (MPV) reference strain

10 entries

Nucleoprotein (Protein N) (Nucleocapsid protein)

Select_allDeselect_all
NCAP_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain
NCAP_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
NCAP_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain
NCAP_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
NCAP_BRSV3
Bovine respiratory syncytial virus (strain 391-2) (BRS)
NCAP_BRSVR
Bovine respiratory syncytial virus (strain Rb94) (BRS)
NCAP_HRSV1
Human respiratory syncytial virus B (strain 18537)
NCAP_HRSVA
Human respiratory syncytial virus A (strain A2)
NCAP_MPV15
Murine pneumonia virus (strain 15) (MPV)

Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

NCAP_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

8 entries

Non-structural protein 1 (Non-structural protein 1C)

Select_allDeselect_all
NS1_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
NS1_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
NS1_HRSS2
Human respiratory syncytial virus A (strain S-2) (HRSV-S2)

Non-structural protein 1 (NS1) (Non-structural protein 1C)

NS1_HRSV1
Human respiratory syncytial virus B (strain 18537)
NS1_HRSVA
Human respiratory syncytial virus A (strain A2)

Non-structural protein 1 (NS1) (Non-structural protein 1C)

NS1_HRSVL
Human respiratory syncytial virus A (strain Long)
NS1_MPV15
Murine pneumonia virus (strain 15) (MPV)
NS1_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

7 entries

Non-structural protein 2 (NS2) (Non-structural protein 1B)

Select_allDeselect_all
NS2_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
NS2_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
NS2_HRSV1
Human respiratory syncytial virus B (strain 18537)
NS2_HRSVA
Human respiratory syncytial virus A (strain A2)
NS2_HRSVL
Human respiratory syncytial virus A (strain Long)
NS2_MPV15
Murine pneumonia virus (strain 15) (MPV)
NS2_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

10 entries

Phosphoprotein (Protein P)

Select_allDeselect_all
PHOSP_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain

Phosphoprotein

PHOSP_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
PHOSP_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain
PHOSP_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
PHOSP_MPV15
Murine pneumonia virus (strain 15) (MPV) reference strain
PHOSP_HRSV
Human respiratory syncytial virus
PHOSP_HRSV1
Human respiratory syncytial virus B (strain 18537)
PHOSP_HRSVA
Human respiratory syncytial virus A (strain A2)
PHOSP_HRSVL
Human respiratory syncytial virus A (strain Long)
PHOSP_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

10 entries

Small hydrophobic protein (Small protein 1A)

Select_allDeselect_all
SH_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain

Small hydrophobic protein

SH_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
SH_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain

Small hydrophobic protein

SH_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
SH_BRSV3
Bovine respiratory syncytial virus (strain 391-2) (BRS)
SH_HRSS2
Human respiratory syncytial virus A (strain S-2) (HRSV-S2)
SH_HRSV1
Human respiratory syncytial virus B (strain 18537)
SH_HRSV8
Human respiratory syncytial virus B (strain 8/60)
SH_HRSVA
Human respiratory syncytial virus A (strain A2)
SH_TRTV
Turkey rhinotracheitis virus (TRTV)

Small hydrophobic protein

3 entries

Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

Select_allDeselect_all
VGLG_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain
VGLG_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain
VGLG_TRTV
Turkey rhinotracheitis virus (TRTV)

Major surface glycoprotein G (Attachment glycoprotein G)

1 entry

Matrix M2 (Envelope-associated 22 kDa protein)

VMA2_TRTV
Turkey rhinotracheitis virus (TRTV)