Thogotovirus

Molecular biology

VIRION

Enveloped, spherical. The virions are 80-120 nm in diameter

GENOME

segmented ssRNA(-) linear genome, encapsidated by nucleoprotein (NP) Contains 6 to 7 segments coding for 7 to 9 proteins. Segments size range from 0.9 to 2.3 kb. Genome total size is about 10 Kb

GENE EXPRESSION

Viral RNA polymerase (PB1, PB2 and PA) transcribes one mRNA from each genome segment. Transcription is primed by cap snatching. mRNA are polyadenylated by the viral polymerase stuttering on a poly U track. Segment 6 mRNA can be alternatively spliced, giving rise to mRNA coding for M1 proteins.

REPLICATION

NUCLEUS

  1. Virus attaches to sialic acid receptor though GP protein and is endocytosed by clathrins in the host cell.
  2. endosome acidification induces fusion of virus membrane with the vesicle membrane; encapsidated RNA segments migrate to the nucleus.
  3. Transcription of genomic segments by the viral polymerase produces mRNAs that are capped and polyadenylated by the viral polymerase.
  4. Replication of genomic segments.
  5. High level of M1 protein induces genomes segments export from nucleus by NEP protein.
  6. Virus assembly and budding occurs at the plasma membrane.

Matching UniProtKB/Swiss-Prot entries

10 entries grouped by strain (browse by keywords)

All proteins are shown (view only 6 complete proteome entries)

6 entries

Thogoto virus (isolate SiAr 126) (Tho) reference strain

Select_allDeselect_all
ENV_THOGV Envelope glycoprotein (Surface glycoprotein 75)
NCAP_THOGV Nucleoprotein (Nucleocapsid protein) (Protein N)
ML_THOGV Protein ML (ML)
PB2_THOGV Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
PA_THOGV Polymerase acidic protein (RNA-directed RNA polymerase subunit P3)
RDRP_THOGV RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (RNA-directed RNA polymerase subunit P2)

4 entries

Dhori virus (strain Indian/1313/61) (Dho)

Select_allDeselect_all
ENV_DHVI1 Envelope glycoprotein
NCAP_DHVI1 Nucleoprotein (Nucleocapsid protein) (Protein N)
M1_DHVI1 Matrix protein 1 (M1)
RDRP_DHVI1 RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (RNA-directed RNA polymerase subunit P2)