Inhibition of host TAP by virus

Transporter associated with antigen (TAP) composed of two subunits TAP1(X57522:9606) and TAP2(M84748:9606), is required for the translocation of peptides into the ER, where they are loaded onto MHC class I. Both subunits consist of an amino-terminal transmembrane domain and a carboxy-terminal nucleotide cytoplasmic domain.

ICP47 BLN2fa US6

The loading of peptide on MHC by TAP is targeted by several viruses including herpesvirus. ICP47(P03170) from HHV-1 binds to the peptide binding site of TAP, with 10-1000 fold higher affinity than most peptides, thereby blocking the first step of the translocation pathway. HCMV US6(P14334) instead interacts with human TAP from the RE luminal side and inhibits ATP binding and peptide stimulated ATP hydrolysis. The UL49.5(Q77CE4) proteins have different strategies to inhibit TAP. Bovine herpesvirus UL49.5(Q77CE4) targets TAP for proteasomal degradation while equine herpesvirus blocks the binding of ATP to TAP. Finally, BNLF2a(P0C739) protein from Epstein-Barr virus prevents the binding of peptides and ATP to TAP.

Matching UniProtKB/Swiss-Prot entries

11 entries grouped by protein (browse by keywords)

All proteins are shown (view only 7 complete proteome entries)

3 entries

Protein BNLF2a

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BNL2A_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BNL2A_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BNL2A_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4) reference strain

5 entries

ICP47 protein (Immediate-early protein IE12) (Immediate-early-5) (Infected cell protein 47) (US12 protein) (Vmw12)

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ICP47_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP47_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
ICP47_CHV16
Cercopithecine herpesvirus 16 (CeHV-16) (Herpesvirus papio 2)
ICP47_CHV1E
Cercopithecine herpesvirus 1 (strain E2490) (CeHV-1) (Simian herpes B virus)
ICP47_HSV2S
Herpes simplex virus type 2 (strain SA8) (Simian agent 8)

3 entries

Unique short US6 glycoprotein

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US06_HCMVA
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Unique short US6 glycoprotein (Protein HXLF6) (gpUS6)

US06_HCMVM
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
US06_HCMVT
Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Unique short US6 glycoprotein (HXLF6) (gpUS6)