Influenza C virus

Molecular biology

VIRION

Enveloped. Usually rounded but can be filamentous. The virions are 80-120 nm in diameter.

GENOME

segmented ssRNA(-) linear genome, encapsidated by nucleoprotein (NP) Contains 7 segments coding for 9 proteins. Segments size range from 0.9 to 2.3 kb. Genome total size is about 10 Kb

GENE EXPRESSION

Viral RNA polymerase (PB1, PB2 and PA) transcribes one mRNA from each genome segment. Transcription is primed by cap snatching. mRNA are polyadenylated by the viral polymerase stuttering on a poly U track. NS mRNA can be alternatively spliced, giving rise to mRNA coding for NEP proteins. Polyprotein p42 is cleaved in M1 and CM2 proteins.

REPLICATION

NUCLEUS

  1. Virus attaches to sialic acid receptor though HEF protein and is endocytosed by clathrins in the host cell.
  2. endosome acidification induces fusion of virus membrane with the vesicle membrane; encapsidated RNA segments migrate to the nucleus.
  3. Transcription of genomic segments by the viral polymerase produces mRNAs that are capped and polyadenylated by the viral polymerase.
  4. Replication of genomic segments.
  5. High level of M1 protein induces genomes segments export from nucleus by NEP protein.
  6. Virus assembly and budding occurs at the plasma membrane.

Host-virus interaction

Innate immune response inhibition

Influenza C virus inhibits the cascade leading to production of interferon-beta by targeting host RIG-I activation through NS1 protein.

Matching UniProtKB/Swiss-Prot entries

31 entries grouped by strain (browse by keywords)

All proteins are shown (view only 13 complete proteome entries)

8 entries

Influenza C virus (strain C/Ann Arbor/1/1950) reference strain

Select_allDeselect_all
HEMA_INCAA Hemagglutinin-esterase-fusion glycoprotein (HEF) (EC 3.1.1.53) [Cleaved into: ...
NEP_INCAA Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NCAP_INCAA Nucleoprotein (Nucleocapsid protein) (Protein N)
MAT_INCAA Polyprotein p42 [Cleaved into: Protein M1' (CM1') (p31); Protein CM2]
NS1_INCAA Non-structural protein 1 (NS1) (NS1C)
PB2_INCAA Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
PA_INCAA Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)
RDRP_INCAA RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

5 entries

Influenza C virus (strain C/California/1978)

Select_allDeselect_all
HEMA_INCCA Hemagglutinin-esterase-fusion glycoprotein (HEF) (EC 3.1.1.53) [Cleaved into: ...
NCAP_INCCA Nucleoprotein (Nucleocapsid protein) (Protein N)
MAT_INCCA Polyprotein p42 [Cleaved into: Protein M1' (CM1') (p31); Protein CM2]
NS1_INCCA Non-structural protein 1 (NS1) (NS1C)
NEP_INCCA Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

5 entries

Influenza C virus (strain C/Johannesburg/1/1966)

Select_allDeselect_all
HEMA_INCJH Hemagglutinin-esterase-fusion glycoprotein (HEF) (EC 3.1.1.53) [Cleaved into: ...
NCAP_INCJH Nucleoprotein (Nucleocapsid protein) (Protein N)
PB2_INCJH Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
PA_INCJH Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)
RDRP_INCJH RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

4 entries

Influenza C virus (strain C/JJ/1950)

Select_allDeselect_all
MAT_INCJJ Polyprotein p42 [Cleaved into: Protein M1' (CM1') (p31); Protein CM2]
PB2_INCJJ Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
PA_INCJJ Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)
RDRP_INCJJ RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) ...

3 entries

Influenza C virus (strain C/Hyogo/1/1983)

Select_allDeselect_all
NEP_INCHY Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
MAT_INCHY Polyprotein p42 [Cleaved into: Protein M1' (CM1') (p31); Protein CM2]
NS1_INCHY Non-structural protein 1 (NS1) (NS1C)

2 entries

Influenza C virus (strain C/Yamagata/1964)

Select_allDeselect_all
NEP_INCY6 Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NS1_INCY6 Non-structural protein 1 (NS1) (NS1C)

1 entry

Influenza C virus (strain C/Berlin/1/1985)

PB2_INCBE Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

1 entry

Influenza C virus (strain C/Nara/2/1985)

HEMA_INCNB Hemagglutinin-esterase-fusion glycoprotein (HEF) (EC 3.1.1.53) [Cleaved into: ...

1 entry

Influenza C virus (strain C/Taylor/1233/1947)

MAT_INCTA Polyprotein p42 [Cleaved into: Protein M1' (CM1') (p31); Protein CM2]

1 entry

Influenza C virus (strain C/Yamagata/4/1988)

HEMA_INCYB Hemagglutinin-esterase-fusion glycoprotein (HEF) (EC 3.1.1.53) [Cleaved into: ...