Henipavirus

Molecular biology

VIRION

Enveloped, spherical. Diameter from about 150nm.

GENOME

Negative-stranded RNA linear genome, about 18 kb in size. Encodes for nine proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. The V protein is produced through RNA editing and the C protein is produced by Leaky scanning of The P mRNA.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through G glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. the ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of MDA-5 antiviral signaling

The P,V and W proteins play a role in inhibition of STAT1 antiviral signaling

Matching UniProtKB/Swiss-Prot entries

18 entries grouped by strain (browse by keywords)

9 entries

Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain

Select_allDeselect_all
C_HENDH Protein C
FUS_HENDH Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
GLYCP_HENDH Glycoprotein G
NCAP_HENDH Nucleoprotein (Protein N) (Nucleocapsid protein)
W_HENDH Protein W
V_HENDH Non-structural protein V
L_HENDH RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_HENDH Matrix protein (Protein M)
PHOSP_HENDH Phosphoprotein (Protein P)

9 entries

Nipah virus

Select_allDeselect_all
C_NIPAV Protein C
FUS_NIPAV Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
GLYCP_NIPAV Glycoprotein G
NCAP_NIPAV Nucleoprotein (Protein N) (Nucleocapsid protein)
V_NIPAV Non-structural protein V
W_NIPAV Protein W
L_NIPAV RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_NIPAV Matrix protein (Protein M)
PHOSP_NIPAV Phosphoprotein (Protein P)