Morbillivirus

VIRION

Enveloped, spherical. Diameter from 150nm to 300nm.

GENOME

Negative-stranded RNA linear genome, about 15-16 kb in size. Encodes for eight proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and “polyadenylated” by the L protein during synthesis. The V protein is produced through RNA editing and the C protein is produced by Leaky scanning of The P mRNA.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through H glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. the ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of MDA-5 antiviral signaling

The V also blocks the type I interferon signaling pathway by interacting with and inhibiting host TYK2

Matching UniProtKB/Swiss-Prot entries

34 entries grouped by protein (browse by keywords)

Only complete proteome entries are shown (view all 90 entries)

3 entries

Protein C

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C_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
C_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
C_RINDR
Rinderpest virus (strain RBOK) (RDV)

4 entries

Fusion glycoprotein F0

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FUS_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
FUS_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
FUS_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
FUS_RINDR
Rinderpest virus (strain RBOK) (RDV)

4 entries

Hemagglutinin glycoprotein

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HEMA_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
HEMA_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
HEMA_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
HEMA_RINDR
Rinderpest virus (strain RBOK) (RDV)

5 entries

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

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L_CDVO
Canine distemper virus (strain Onderstepoort) (CDV) reference strain
L_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
L_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
L_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
L_RINDR
Rinderpest virus (strain RBOK) (RDV)

4 entries

Matrix protein

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MATRX_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
MATRX_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
MATRX_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
MATRX_RINDR
Rinderpest virus (strain RBOK) (RDV)

8 entries

Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

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NCAP_CDVO
Canine distemper virus (strain Onderstepoort) (CDV) reference strain

Nucleoprotein (Protein N) (Nucleocapsid protein)

NCAP_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
NCAP_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
NCAP_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
NCAP_MEASM
Measles virus (strain Edmonston-Moraten vaccine) (MeV) (Subacute sclerose panencephalitis virus)
NCAP_MEASW
Measles virus (strain Edmonston-Schwarz vaccine) (MeV) (Subacute sclerose panencephalitis virus)
NCAP_PPRV
Peste-des-petits-ruminants virus (PPRV)
NCAP_RINDR
Rinderpest virus (strain RBOK) (RDV)

3 entries

Phosphoprotein (Protein P)

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PHOSP_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
PHOSP_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
PHOSP_RINDR
Rinderpest virus (strain RBOK) (RDV)

3 entries

Non-structural protein V

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V_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
V_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)