Pneumovirus

Molecular biology

VIRION

Enveloped, spherical. Diameter from about 150nm nm.

GENOME

Negative-stranded RNA linear genome, about 15 kb in size. Encodes for 11 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The NS2 protein plays a role in inhibition of RIG-I antiviral signaling

The NS1 protein plays a role in inhibition of MAVS antiviral signaling

Activation of host NF-kappa-B

The HRSV M2-1 can activate NF-kappa-B signaling through interaction with host RELA.

Matching UniProtKB/Swiss-Prot entries

7 entries grouped by strain (browse by keywords)

7 entries

Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

Select_allDeselect_all
GLYC_ORSVW Major surface glycoprotein G (Attachment glycoprotein G)
NCAP_ORSVW Nucleoprotein (Protein N) (Nucleocapsid protein)
M21_ORSVW Matrix M2-1 (Envelope-associated 22 kDa protein)
MATRX_ORSVW Matrix protein
NS1_ORSVW Non-structural protein 1 (Non-structural protein 1C)
NS2_ORSVW Non-structural protein 2 (NS2) (Non-structural protein 1B)
PHOSP_ORSVW Phosphoprotein (Protein P)