Inhibition of host apoptosis by viral BCL2-like protein

Cellular Bcl-2 family proteins regulate critical steps in programmed cell death pathway by modulating mitochondrial permeability and function. They can be divided on two distinct groups, anti-apoptotic members such as Bcl-2 and Bcl-Xl that prevent cell death and pro-apoptotic elements like Bax and Bak that promote apoptosis.

tnf tnfr tradd fadd casp8 casp8 bax bak vbcl2 vbcl2 apaf1 bcl2 casp3 casp9 casp3 Image Map
Bcl-2 family proteins are also encoded by several large DNA viruses, including all known gamma herpesviruses, adenoviruses, and several other unrelated viruses. Viral Bcl-2 proteins can prevent cell death but often escape cellular regulatory mechanisms that govern their cellular counterparts. Compared to the cellular Bcl-2, viral Bcl-2 members are shorter and are often devoid of a membrane-anchored domain. Even with low level of homology with Bcl-2 such as adenovirus E1B19K, all viral Bcl-2 proteins analyzed so far are able to block apoptosis.

Matching UniProtKB/Swiss-Prot entries

30 entries grouped by protein (browse by keywords)

All proteins are shown (view only 17 complete proteome entries)

7 entries

Apoptosis regulator Bcl-2 homolog

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ARBH_ASFB7
African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV) reference strain
ARBH_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
ARBH_ASFE4
African swine fever virus (strain E-70 MS44) (ASFV)

Apoptosis regulator Bcl-2 homolog (LMH-5W)

ARBH_ASFK5
African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV)
ARBH_ASFM2
African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV)
ARBH_ASFP4
African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) (ASFV)
ARBH_ASFWA
African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV)

15 entries

E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)

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E1BS_ADE02
Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K) (E1B-175R)

E1BS_ADE05
Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) reference strain
E1BS_ADE12
Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12) reference strain
E1BS_ADE04
Human adenovirus E serotype 4 (HAdV-4) (Human adenovirus 4)
E1BS_ADE07
Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7)
E1BS_ADE40
Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40)
E1BS_ADE41
Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41)
E1BS_ADEC2
Canine adenovirus serotype 2 (CAdV-2) (Canine adenovirus 2)
E1BS_ADECC
Canine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL))
E1BS_ADECG
Canine adenovirus serotype 1 (strain Glaxo) (CAdV-1) (Canine adenovirus 1 (strain Glaxo))
E1BS_ADECR
Canine adenovirus serotype 1 (strain RI261) (CAdV-1) (Canine adenovirus 1 (strain RI261))
E1BS_ADECT
Canine adenovirus serotype 2 (strain Toronto A 26-61) (CAdV-2) (Canine adenovirus 2 (strain Toronto A 26-61))
E1BS_ADEM1
Murine adenovirus A serotype 1 (MAdV-1) (Murine adenovirus 1)
E1BS_ADES7
Simian adenovirus serotype 7 (SAdV-7) (Simian adenovirus 7)
E1BS_ADET1
Tree shrew adenovirus serotype 1 (TSAdV-1) (Tupaia adenovirus 1)

E1B protein, small T-antigen homolog (E1B 19 kDa protein) (E1B-19K)

5 entries

Protein F1

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F1_VACCC
Vaccinia virus (strain Copenhagen) (VACV) reference strain
F1_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain
F1_RABPU
Rabbitpox virus (strain Utrecht) (RPV)
F1_VACCA
Vaccinia virus (strain Ankara) (VACV)
F1_VACCT
Vaccinia virus (strain Tian Tan) (VACV)

1 entry

Bcl-2-like protein FPV039

V039_FOWPN
Fowlpox virus (strain NVSL) (FPV) reference strain

1 entry

Bcl-2-like gene 16 protein

VG16_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Putative apoptosis regulator A9

VGA9_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain