Pore-mediated penetration of viral genome into host cell



Some non-enveloped viruses inject their genome into the host cytoplasm through creation of a pore in the host membrane. This is mediated by a viral pore-forming peptide associated with the viral capsid.

The icosahedric capsid of picornaviridae is able to create a pore either at plasma or endosomal membrane to inject their genomic RNA.

Papillomaviridae and polyomaviridae seem to enter the endoplasmic reticulum where their icosahedric capsid is disassembled, releasing pore forming proteins that induce injection of genomic DNA into cell cytoplasm.

Prokaryotic viruses such as caudovirales eject their genome into the host cytoplasm through a complex ejection apparatus. This mechanism often involves pore formation in the host membrane(s).

Matching UniProtKB/Swiss-Prot entries

48 entries grouped by protein (browse by keywords)

4 entries

Tail knob protein gp9 (Distal tube protein) (Gene product 9) (gp9) (Protein p9)

Select_allDeselect_all
DIT9_BPNF
Bacillus phage Nf (Bacteriophage Nf) reference strain

Tail knob protein gp9 (Distal tube protein) (Gene product 9) (gp9) (Protein p9) (Tail protein)

DIT9_BPPH2
Bacillus phage phi29 (Bacteriophage phi-29) reference strain
DIT9_BPB03
Bacillus phage B103 (Bacteriophage B103)
DIT9_BPPZA
Bacillus phage PZA (Bacteriophage PZA)

1 entry

Tail needle protein gp26 (Head completion protein) (Packaged DNA stabilization protein) (Tail accessory factor gp26)

NEEDL_BPP22
Salmonella phage P22 (Bacteriophage P22) reference strain

41 entries

Genome polyprotein

Select_allDeselect_all
POLG_HRV8A
Human rhinovirus A serotype 89 (strain 41467-Gallo) (HRV-89) reference strain
POLG_POL1M
Poliovirus type 1 (strain Mahoney) reference strain
POLG_BOVEV
Bovine enterovirus (strain VG-5-27) (BEV)
POLG_CX16G
Coxsackievirus A16 (strain G-10)
POLG_CX16T
Coxsackievirus A16 (strain Tainan/5079/98)
POLG_CXA21
Coxsackievirus A21 (strain Coe)
POLG_CXA24
Coxsackievirus A24 (strain EH24/70)
POLG_CXA9
Coxsackievirus A9 (strain Griggs)
POLG_CXB1J
Coxsackievirus B1 (strain Japan)
POLG_CXB2O
Coxsackievirus B2 (strain Ohio-1)
POLG_CXB3N
Coxsackievirus B3 (strain Nancy)
POLG_CXB3W
Coxsackievirus B3 (strain Woodruff)
POLG_CXB4E
Coxsackievirus B4 (strain E2)
POLG_CXB4J
Coxsackievirus B4 (strain JVB / Benschoten / New York/51)
POLG_CXB5P
Coxsackievirus B5 (strain Peterborough / 1954/UK/85)
POLG_CXB6S
Coxsackievirus B6 (strain Schmitt)
POLG_EC01F
Echovirus 1 (strain Human/Egypt/Farouk/1951) (E-1)
POLG_EC05N
Echovirus 5 (strain Noyce)
POLG_EC06C
Echovirus 6 (strain Charles)
POLG_EC09B
Echovirus 9 (strain Barty)
POLG_EC09H
Echovirus 9 (strain Hill)
POLG_EC11G
Echovirus 11 (strain Gregory)
POLG_EC12T
Echovirus 12 (strain Travis)
POLG_EC30B
Echovirus 30 (strain Bastianni)
POLG_HE701
Human enterovirus 70 (strain J670/71) (EV 70)
POLG_HE71B
Human enterovirus 71 (strain BrCr) (Ev 71)
POLG_HE71M
Human enterovirus 71 (strain 7423/MS/87) (Ev 71)
POLG_HRV14
Human rhinovirus 14 (HRV-14)
POLG_HRV16
Human rhinovirus 16 (HRV-16)
POLG_HRV1A
Human rhinovirus 1A (HRV-1A)
POLG_HRV1B
Human rhinovirus 1B (HRV-1B)
POLG_HRV2
Human rhinovirus 2 (HRV-2)
POLG_HRV3
Human rhinovirus 3 (HRV-3)
POLG_PEV9U
Porcine enterovirus 9 (strain UKG/410/73)
POLG_POL1S
Poliovirus type 1 (strain Sabin)
POLG_POL2L
Poliovirus type 2 (strain Lansing)
POLG_POL2W
Poliovirus type 2 (strain W-2)
POLG_POL32
Poliovirus type 3 (strain 23127)
POLG_POL3L
Poliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)
POLG_SVDVH
Swine vesicular disease virus (strain H/3 '76) (SVDV)
POLG_SVDVU
Swine vesicular disease virus (strain UKG/27/72) (SVDV)

1 entry

Spike protein (Baseplate assembly protein gpV) (Gene V protein) (GpV)

SPIKE_BPP2
Escherichia phage P2 (Bacteriophage P2) reference strain

1 entry

Probable tape measure protein (Tail protein pb2)

TMP_BPT5
Escherichia phage T5 (Enterobacteria phage T5) reference strain