Fusion of virus membrane with host cell membrane


Several viruses are able to directly fuse their membrane with cell plasma membrane without being internalized by endocytosis or macropinocytosis. These capacity confers them usualy the possibility to create cell syncytia
The fusion between viral and cellular membrane is triggered by fusion proteins. All fusion proteins are active in a trimeric conformation. Most of them are natively trimeric, some of them are dimers on the virion surface but are converted to trimers upon activation .
Fusion proteins have to be produced in an inactive state in order to avoid to trigger fusion in the Golgi or other compartments upon synthesis and transport to the cell surface. Many are activated in the trans.Golgi network or at the cell surface by proteolytic cleavage which reveals the fusion peptide.

Fusion mechanism according to the “viral fusion pore” model of Lee K: . A different model has been described with PIV5

Matching UniProtKB/Swiss-Prot entries

125 entries grouped by protein (browse by keywords)

Only complete proteome entries are shown (view all 237 entries)

26 entries

Envelope glycoprotein (Env polyprotein)

Select_allDeselect_all
ENV_HTL1C
Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) reference strain

Envelope glycoprotein gp62 (Env polyprotein)

ENV_HTL32
Human T-cell leukemia virus 3 (strain 2026ND) (HTLV-3) reference strain

Envelope glycoprotein gp63 (Env polyprotein)

ENV_HTLV2
Human T-cell leukemia virus 2 (HTLV-2) reference strain

Envelope glycoprotein gp63 (Env polyprotein)

ENV_MLVMS
Moloney murine leukemia virus (isolate Shinnick) (MoMLV) reference strain

Envelope glycoprotein (Pr80env) (Env polyprotein)

ENV_MMTVC
Mouse mammary tumor virus (strain C3H) (MMTV) reference strain

Envelope glycoprotein gp70 (Env polyprotein)

ENV_RSVSA
Avian leukosis virus RSA (RSV-SRA) (Rous sarcoma virus (strain Schmidt-Ruppin A)) reference strain

Envelope glycoprotein gp95 (Env polyprotein)

ENV_WDSV
Walleye dermal sarcoma virus (WDSV) reference strain
ENV_XMRV6
Xenotropic MuLV-related virus (isolate VP62) (XMRV) reference strain
ENV_BAEVM
Baboon endogenous virus (strain M7)
ENV_GALV
Gibbon ape leukemia virus (GALV)
ENV_HTL1A
Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1)

Envelope glycoprotein gp62 (Env polyprotein)

ENV_HTL3P
Human T-cell leukemia virus 3 (strain Pyl43) (HTLV-3)

Envelope glycoprotein gp63 (Env polyprotein)

ENV_JSRV
Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) (JSRV)
ENV_KORV
Koala retrovirus (KoRV)
ENV_MLVAV
AKV murine leukemia virus (AKR (endogenous) murine leukemia virus)
ENV_MLVF5
Friend murine leukemia virus (isolate 57) (FrMLV)
ENV_MLVFF
Friend murine leukemia virus (isolate FB29) (FrMLV)
ENV_MLVFP
Friend murine leukemia virus (isolate PVC-211) (FrMLV)
ENV_MLVRD
Radiation murine leukemia virus
ENV_MPMV
Mason-Pfizer monkey virus (MPMV) (Simian Mason-Pfizer virus)
ENV_RSVP
Rous sarcoma virus (strain Prague C) (RSV-PrC)

Envelope glycoprotein gp95 (Env polyprotein)

ENV_SMRVH
Squirrel monkey retrovirus (SMRV-H) (SMRV-HLB)
ENV_SRV1
Simian retrovirus SRV-1
ENV_SRV2
Simian retrovirus SRV-2
ENV_XMRV3
Xenotropic MuLV-related virus (isolate VP35) (XMRV)
ENV_XMRV4
Xenotropic MuLV-related virus (isolate VP42) (XMRV)

22 entries

Fusion glycoprotein F0

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FUS_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain

Fusion glycoprotein F0 (Protein F)

FUS_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
FUS_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain

Fusion glycoprotein F0 (Protein F)

FUS_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain

Fusion glycoprotein F0 (Protein F)

FUS_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain

Fusion glycoprotein F0 (Protein F)

FUS_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
FUS_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain
FUS_NDVB1
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
FUS_PI2HT
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
FUS_PI3B
Bovine parainfluenza 3 virus (BPIV-3) reference strain
FUS_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
FUS_SENDO
Sendai virus (strain Ohita) (SeV) reference strain

Fusion glycoprotein F0 (Protein F)

FUS_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain

Fusion glycoprotein F0 (Protein F)

FUS_SV41
Simian virus 41 (SV41) reference strain
FUS_HRSVA
Human respiratory syncytial virus A (strain A2)

Fusion glycoprotein F0 (Protein F)

FUS_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
FUS_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
FUS_MPV15
Murine pneumonia virus (strain 15) (MPV)
FUS_NIPAV
Nipah virus

Fusion glycoprotein F0 (Protein F)

FUS_RINDR
Rinderpest virus (strain RBOK) (RDV)
FUS_SENDA
Sendai virus (strain Hamamatsu) (SeV)

Fusion glycoprotein F0 (Protein F)

FUS_SENDF
Sendai virus (strain Fushimi) (SeV)

Fusion glycoprotein F0 (Protein F)

5 entries

Protein G3

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G3_FOWPN
Fowlpox virus (strain NVSL) (FPV) reference strain

Protein G3 homolog (Protein FPV078)

G3_VACCC
Vaccinia virus (strain Copenhagen) (VACV) reference strain
G3_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain
G3_VAR67
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain
G3_VACCT
Vaccinia virus (strain Tian Tan) (VACV)

5 entries

Myristoylated protein G9

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G9_VACCC
Vaccinia virus (strain Copenhagen) (VACV) reference strain
G9_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

Myristoylated protein G9 (Protein F1)

G9_VAR67
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain
G9_VACCA
Vaccinia virus (strain Ankara) (VACV)
G9_VACCT
Vaccinia virus (strain Tian Tan) (VACV)

20 entries

Envelope glycoprotein H (gH)

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GH_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain
GH_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
GH_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
GH_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4) reference strain
GH_EHV1B
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain
GH_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain
GH_GAHVM
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) reference strain
GH_HCMVA
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
GH_HCMVM
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
GH_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GH_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GH_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
GH_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
GH_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain
GH_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
GH_MUHVS
Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus) reference strain
GH_PSHV1
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus) reference strain
GH_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain
GH_VZVD
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain
GH_VZVO
Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)

21 entries

Envelope glycoprotein L (gL)

Select_allDeselect_all
GL_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain
GL_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
GL_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
GL_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4) reference strain
GL_EHV1B
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain
GL_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain
GL_GAHVM
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) reference strain
GL_HCMVA
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
GL_HCMVM
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
GL_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GL_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GL_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
GL_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
GL_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain
GL_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
GL_MUHVS
Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus) reference strain
GL_PSHV1
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus) reference strain
GL_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain
GL_VZVD
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain
GL_EHV1V
Equine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus)
GL_VZVO
Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)

3 entries

Protein H2

Select_allDeselect_all
H2_VACCC
Vaccinia virus (strain Copenhagen) (VACV) reference strain
H2_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain
H2_VAR67
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain

Late protein H2

5 entries

Protein J5

Select_allDeselect_all
J5_FOWPN
Fowlpox virus (strain NVSL) (FPV) reference strain

Protein J5 homolog (FPV136)

J5_VACCC
Vaccinia virus (strain Copenhagen) (VACV) reference strain
J5_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

Protein J5 (Protein F11)

J5_VAR67
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain
J5_VACCA
Vaccinia virus (strain Ankara) (VACV)

5 entries

Protein L5

Select_allDeselect_all
L5_FOWPN
Fowlpox virus (strain NVSL) (FPV) reference strain

L5 homolog (Protein FPV132)

L5_VACCC
Vaccinia virus (strain Copenhagen) (VACV) reference strain
L5_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

Protein L5 (Protein F6)

L5_VAR67
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain
L5_VACCA
Vaccinia virus (strain Ankara) (VACV)

13 entries

Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)

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SPIKE_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain
SPIKE_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain
SPIKE_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
SPIKE_CVP67
Porcine hemagglutinating encephalomyelitis virus (strain 67N) (HEV-67N) reference strain
SPIKE_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
SPIKE_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
SPIKE_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
SPIKE_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
SPIKE_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
SPIKE_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
SPIKE_CVHOC
Human coronavirus OC43 (HCoV-OC43)
SPIKE_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)
SPIKE_CVPIA
Porcine hemagglutinating encephalomyelitis virus (strain IAF-404) (HEV)