Hepadnaviridae

VIRION

Enveloped, spherical. Diameter from about 42nm. Icosahedric capsid with a T=4 symmetry.

GENOME

Partially dsDNA circular genome, about 3.2 kb in size. Encodes for 7 proteins.
On rare non-specific recombination, the viral genome can be integrated in host chromosome. This inactivates the integrated virus but can gives the host cell a replicative advantage sometimes leading to hepatocarcinoma.

GENE EXPRESSION

The minichromosome is transcribed by cellular RNA polymerase II under the control of three to four promoters (the core, pre-S1, pre-S2/S promoters, and the X promoter in mammalian viruses) and two enhancer regions (ENH1 and ENH2). The pre-genomic RNA is alternatively spliced. The unspliced form is exported from the nucleus through a PRE motif possibly by capsid protein. The Polymerase and short S proteins are expressed by leaky scanning from the pg mRNA and the S mRNA respectively.

REPLICATION

CYTOPLASMIC/NUCLEAR

  1. Virus attaches to host receptors through major surface antigen and enters the cell by an unknown mechanism.
  2. Relaxed circular DNA (RC-DNA) and capsid are transported via microtubules to the nucleus where DNA is released through the nuclear pore, and repaired to form covalently closed circular DNA (cccDNA).
  3. Transcription by RNA polymerase II of the pregenomic RNA (pgRNA) and subgenomic mRNAs, inducing synthesis of all the viral proteins.
  4. pgRNA is encapsidated, together with the P protein, and reverse-transcribed inside the nucleocapsid in (-)DNA covalently linked to P protein.
  5. (+)DNA synthesis from the (-)DNA template generates new RC-DNA.
  6. Transport to the nucleus of new RC-DNA leads to cccDNA amplification; alternatively, the RC-DNA containing nucleocapsids are enveloped at the ER, and new virions are released by exocytosis.

Host-virus interaction

Primary receptor

HBV L surface protein can bind to heparan sulfate

Entry receptor

HBV L surface protein Binds to SLC10A1/NTCP in order to enter hepatocytes.

Autophagy modulation

HBV protein HBx seems to be able to increase autophagy through the up-regulation of host beclin 1 expression .

Cell-cycle modulation

HBV protein HBx protein deregulates cell cycle checkpoint controls at G0/G1 and G2/M .

Innate immune response inhibition

HBV protein HBx directly interacts with and inhibits host MAVS protein by inducing its ubiquitination and targeting it for degradation .

Matching UniProtKB/Swiss-Prot entries

292 entries grouped by strain (browse by keywords)

All proteins are shown (view only 282 complete proteome entries)

7 entries

Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) (HBV-D) reference strain

Select_allDeselect_all
CAPSD_HBVD3 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVD3 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVD3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HBVD3 External core antigen (HBeAg) (Precore protein) (p25)
Y15K_HBVD3 Putative uncharacterized 15.3 kDa protein
Y10K_HBVD3 Putative uncharacterized 10.4 kDa protein
X_HBVD3 Protein X (HBx) (Peptide X) (pX)

5 entries

Ground squirrel hepatitis virus (strain 27) (GSHV) reference strain

Select_allDeselect_all
CAPSD_GSHV Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_GSHV Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_GSHV Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_GSHV External core antigen (HBeAg) (Precore protein) (p25)
X_GSHV Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-) (HBV-C) reference strain

Select_allDeselect_all
CAPSD_HBVCJ Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVCJ Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVCJ Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HBVCJ External core antigen (HBeAg) (Precore protein) (p25)
X_HBVCJ Protein X (HBx) (Peptide X) (pX)

4 entries

Duck hepatitis B virus (isolate Shanghai/DHBVQCA34) (DHBV) reference strain

Select_allDeselect_all
CAPSD_DHBVQ Capsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_DHBVQ Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_DHBVQ Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_DHBVQ External core antigen (HBeAg) (Precore protein)

1 entry

Duck hepatitis B virus (strain United States/DHBV-16) (DHBV) reference strain

HBSAG_DHBV1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

5 entries

Chimpanzee hepatitis B virus (isolate United Kingdom/LSH/1988) (HBVcpz)

Select_allDeselect_all
CAPSD_HBVCP Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVCP Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVCP Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HBVCP Truncated HBeAg protein
X_HBVCP Protein X (HBx) (Peptide X) (pX)

5 entries

Gibbon hepatitis B virus subtype ayw3q (isolate Hope) (HBVgbn)

Select_allDeselect_all
CAPSD_HBVGB Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVGB Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HBVGB External core antigen (HBeAg) (Precore protein) (p25)
HBSAG_HBVGB Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVGB Protein X (HBx) (Peptide X) (pX)

5 entries

Gorilla hepatitis B virus (isolate Cameroon/gor97) (HBVgor)

Select_allDeselect_all
CAPSD_HBVGO Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVGO Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HBVGO External core antigen (HBeAg) (Precore protein) (p25)
HBSAG_HBVGO Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVGO Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype A1 subtype adw2 (isolate South Africa/84/2001) (HBV-A)

Select_allDeselect_all
CAPSD_HBVA6 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVA6 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVA6 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HBVA6 External core antigen (HBeAg) (Precore protein) (p25)
X_HBVA6 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype A2 (isolate Japan/11D11HCCW/1998) (HBV-A)

Select_allDeselect_all
CAPSD_HBVA7 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVA7 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVA7 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HBVA7 External core antigen (HBeAg) (Precore protein) (p25)
X_HBVA7 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype A2 subtype adw (isolate Japan/Nishioka/1983) (HBV-A)

Select_allDeselect_all
CAPSD_HBVA2 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVA2 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVA2 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HBVA2 External core antigen (HBeAg) (Precore protein) (p25)
X_HBVA2 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype A2 subtype adw2 (isolate Germany/991/1990) (HBV-A)

Select_allDeselect_all
CAPSD_HBVA4 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVA4 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVA4 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HBVA4 External core antigen (HBeAg) (Precore protein) (p25)
X_HBVA4 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979) (HBV-A)

Select_allDeselect_all
CAPSD_HBVA3 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVA3 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HBVA3 External core antigen (HBeAg) (Precore protein) (p25)
HBSAG_HBVA3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVA3 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype A3 (isolate Cameroon/CMR711/1994) (HBV-A)

Select_allDeselect_all
CAPSD_HBVA9 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVA9 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVA9 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HBVA9 External core antigen (HBeAg) (Precore protein) (p25)
X_HBVA9 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype A3 (isolate Cameroon/CMR983/1994) (HBV-A)

Select_allDeselect_all
CAPSD_HBVA8 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVA8 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HBVA8 External core antigen (HBeAg) (Precore protein) (p25)
HBSAG_HBVA8 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVA8 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype B/C subtype adw (isolate Okinawa/pODW282/1998) (HBV-B)

Select_allDeselect_all
CAPSD_HBVB4 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVB4 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVB4 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HBVB4 External core antigen (HBeAg) (Precore protein) (p25)
X_HBVB4 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype B1 (isolate Japan/Ry30/2002) (HBV-B)

Select_allDeselect_all
CAPSD_HBVB8 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVB8 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HBVB8 Truncated HBeAg protein
HBSAG_HBVB8 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVB8 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype B1 (isolate Japan/Yamagata-2/1998) (HBV-B)

Select_allDeselect_all
CAPSD_HBVB7 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVB7 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVB7 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HBVB7 Truncated HBeAg protein
X_HBVB7 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype B1 subtype adw (isolate Japan/pJDW233/1988) (HBV-B)

Select_allDeselect_all
CAPSD_HBVB1 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVB1 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HBVB1 External core antigen (HBeAg) (Precore protein) (p25)
HBSAG_HBVB1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVB1 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype B2 (isolate Indonesia/pIDW420/1988) (HBV-B)

Select_allDeselect_all
CAPSD_HBVB2 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVB2 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVB2 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HBVB2 External core antigen (HBeAg) (Precore protein) (p25)
X_HBVB2 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype B2 (isolate Vietnam/9873/1997) (HBV-B)

Select_allDeselect_all
CAPSD_HBVB3 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVB3 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HBVB3 Truncated HBeAg protein
HBSAG_HBVB3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVB3 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype B2 subtype adw (isolate China/patient4/1996) (HBV-B)

Select_allDeselect_all
CAPSD_HBVB6 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVB6 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVB6 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HBVB6 Truncated HBeAg protein
X_HBVB6 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype C (isolate Vietnam/3270/2000) (HBV-C)

Select_allDeselect_all
CAPSD_HBVC0 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVC0 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HBVC0 External core antigen (HBeAg) (Precore protein) (p25)
HBSAG_HBVC0 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVC0 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype C subtype adr (isolate Japan/Nishioka/1983) (HBV-C)

Select_allDeselect_all
CAPSD_HBVC1 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVC1 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HBVC1 External core antigen (HBeAg) (Precore protein) (p25)
HBSAG_HBVC1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVC1 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype C subtype adr (strain Japan/adr4/1983) (HBV-C)

Select_allDeselect_all
CAPSD_HBVC3 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVC3 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HBVC3 External core antigen (HBeAg) (Precore protein) (p25)
HBSAG_HBVC3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVC3 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype C subtype ar (isolate Japan/S-207/1988) (HBV-C)

Select_allDeselect_all
CAPSD_HBVC2 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVC2 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HBVC2 External core antigen (HBeAg) (Precore protein) (p25)
HBSAG_HBVC2 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVC2 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype C subtype ayw (isolate Australia/AustRC/1992) (HBV-C)

Select_allDeselect_all
CAPSD_HBVC9 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVC9 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVC9 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HBVC9 Truncated HBeAg protein
X_HBVC9 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype C subtype ayw (isolate China/Tibet127/2002) (HBV-C)

Select_allDeselect_all
CAPSD_HBVC7 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVC7 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HBVC7 External core antigen (HBeAg) (Precore protein) (p25)
HBSAG_HBVC7 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVC7 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype D (isolate France/alpha1/1989) (HBV-D)

Select_allDeselect_all
CAPSD_HBVD2 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVD2 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HBVD2 Truncated HBeAg protein
HBSAG_HBVD2 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVD2 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype D (isolate Germany/1-91/1991) (HBV-D)

Select_allDeselect_all
CAPSD_HBVD7 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVD7 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVD7 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HBVD7 External core antigen (HBeAg) (Precore protein) (p25)
X_HBVD7 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype D subtype ayw (isolate Australia/AustKW/1991) (HBV-D)

Select_allDeselect_all
CAPSD_HBVD5 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVD5 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HBVD5 External core antigen (HBeAg) (Precore protein) (p25)
HBSAG_HBVD5 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVD5 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype D subtype ayw (isolate Italy/CI/1992) (HBV-D)

Select_allDeselect_all
CAPSD_HBVD6 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVD6 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HBVD6 External core antigen (HBeAg) (Precore protein) (p25)
HBSAG_HBVD6 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVD6 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype D subtype ayw (isolate Japan/JYW796/1988) (HBV-D)

Select_allDeselect_all
CAPSD_HBVD4 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVD4 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVD4 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HBVD4 Truncated HBeAg protein
X_HBVD4 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype F2 (isolate Brazil/w4B) (HBV-F)

Select_allDeselect_all
CAPSD_HBVF1 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVF1 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVF1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HBVF1 External core antigen (HBeAg) (Precore protein) (p25)
X_HBVF1 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype F2 subtype adw4q (isolate Senegal/9203) (HBV-F)

Select_allDeselect_all
CAPSD_HBVF6 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVF6 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HBVF6 External core antigen (HBeAg) (Precore protein) (p25)
HBSAG_HBVF6 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVF6 Protein X (HBx) (Peptide X) (pX)

5 entries

Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/2928Nic/1997) (HBV-H)

Select_allDeselect_all
CAPSD_HBVH3 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVH3 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HBVH3 External core antigen (HBeAg) (Precore protein) (p25)
HBSAG_HBVH3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVH3 Protein X (HBx) (Peptide X) (pX)

5 entries

Woodchuck hepatitis B virus (isolate 1) (WHV)

Select_allDeselect_all
CAPSD_WHV1 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_WHV1 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_WHV1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_WHV1 External core antigen (HBeAg) (Precore protein) (p25)
X_WHV1 Protein X (HBx) (Peptide X) (pX)

5 entries

Woodchuck hepatitis B virus (isolate 2) (WHV)

Select_allDeselect_all
CAPSD_WHV2 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_WHV2 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_WHV2 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_WHV2 External core antigen (HBeAg) (Precore protein) (p25)
X_WHV2 Protein X (HBx) (Peptide X) (pX)

5 entries

Woodchuck hepatitis B virus (isolate 59) (WHV)

Select_allDeselect_all
CAPSD_WHV3 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_WHV3 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_WHV3 External core antigen (HBeAg) (Precore protein) (p25)
HBSAG_WHV3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_WHV3 Protein X (HBx) (Peptide X) (pX)

5 entries

Woodchuck hepatitis B virus (isolate 7) (WHV)

Select_allDeselect_all
CAPSD_WHV4 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_WHV4 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_WHV4 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_WHV4 External core antigen (HBeAg) (Precore protein) (p25)
X_WHV4 Protein X (HBx) (Peptide X) (pX)

5 entries

Woodchuck hepatitis B virus (isolate 8) (WHV)

Select_allDeselect_all
CAPSD_WHV5 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_WHV5 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_WHV5 External core antigen (HBeAg) (Precore protein) (p25)
HBSAG_WHV5 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_WHV5 Protein X (HBx) (Peptide X) (pX)

5 entries

Woolly monkey hepatitis B virus (isolate Louisville) (WMHBV)

Select_allDeselect_all
CAPSD_WMHBV Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_WMHBV Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_WMHBV Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_WMHBV External core antigen (HBeAg) (Precore protein) (p25)
X_WMHBV Protein X (HBx) (Peptide X) (pX)

4 entries

Arctic squirrel hepatitis virus (ASHV)

Select_allDeselect_all
CAPSD_ASHV Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_ASHV Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_ASHV External core antigen (HBeAg) (Precore protein) (p25)
X_ASHV Protein X (HBx) (Peptide X) (pX)

4 entries

Duck hepatitis B virus (isolate brown Shanghai duck S5) (DHBV)

Select_allDeselect_all
CAPSD_HPBDB Capsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_HPBDB Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HPBDB External core antigen (HBeAg) (Precore protein)
HBSAG_HPBDB Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

4 entries

Duck hepatitis B virus (isolate white Shanghai duck S31) (DHBV)

Select_allDeselect_all
CAPSD_HPBDW Capsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_HPBDW Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HPBDW Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HPBDW External core antigen (HBeAg) (Precore protein)

4 entries

Duck hepatitis B virus (strain China) (DHBV)

Select_allDeselect_all
CAPSD_HPBDC Capsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_HPBDC Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HPBDC Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HPBDC External core antigen (HBeAg) (Precore protein)

4 entries

Duck hepatitis B virus (strain Germany/DHBV-3) (DHBV)

Select_allDeselect_all
CAPSD_DHBV3 Capsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_DHBV3 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_DHBV3 External core antigen (HBeAg) (Precore protein)
HBSAG_DHBV3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

3 entries

Duck hepatitis B virus (strain United States/DHBV-16) (DHBV)

Select_allDeselect_all
CAPSD_DHBV1 Capsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_DHBV1 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_DHBV1 External core antigen (HBeAg) (Precore protein)

4 entries

Hepatitis B virus genotype A1 subtype adw (isolate Philippines/pFDW294/1988) (HBV-A)

Select_allDeselect_all
CAPSD_HBVA5 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVA5 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HBVA5 External core antigen (HBeAg) (Precore protein) (p25)
HBSAG_HBVA5 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

4 entries

Hepatitis B virus genotype C subtype ad (isolate Japan/S-179/1988) (HBV-C)

Select_allDeselect_all
CAPSD_HBVC5 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVC5 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVC5 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVC5 Protein X (HBx) (Peptide X) (pX)

4 entries

Hepatitis B virus genotype C subtype adr (isolate Japan/A4/1994) (HBV-C)

Select_allDeselect_all
CAPSD_HBVC8 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVC8 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVC8 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVC8 Protein X (HBx) (Peptide X) (pX)

4 entries

Hepatitis B virus genotype C subtype adr (isolate Korea/Kim/1989) (HBV-C)

Select_allDeselect_all
CAPSD_HBVC4 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVC4 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVC4 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
XCORE_HBVC4 Putative X-Core fused protein

4 entries

Hepatitis B virus genotype G (isolate IG29227/2000) (HBV-G)

Select_allDeselect_all
CAPSD_HBVG3 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVG3 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVG3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVG3 Protein X (HBx) (Peptide X) (pX)

4 entries

Heron hepatitis B virus (HHBV)

Select_allDeselect_all
CAPSD_HHBV Capsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_HHBV Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HHBV Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HHBV External core antigen (HBeAg) (Precore protein)

3 entries

Hepatitis B virus genotype B2 (isolate Vietnam/16091/1992) (HBV-B)

Select_allDeselect_all
DPOL_HBVB5 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVB5 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVB5 Protein X (HBx) (Peptide X) (pX)

3 entries

Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-129/2003) (HBV-E)

Select_allDeselect_all
DPOL_HBVE2 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVE2 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVE2 Protein X (HBx) (Peptide X) (pX)

3 entries

Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-212/2003) (HBV-E)

Select_allDeselect_all
DPOL_HBVE4 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVE4 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVE4 Protein X (HBx) (Peptide X) (pX)

3 entries

Hepatitis B virus genotype E subtype ayw4 (isolate Kou) (HBV-E)

Select_allDeselect_all
DPOL_HBVE1 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVE1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVE1 Protein X (HBx) (Peptide X) (pX)

3 entries

Hepatitis B virus genotype F2 (isolate Argentina/sa16/2000) (HBV-F)

Select_allDeselect_all
DPOL_HBVF4 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVF4 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVF4 Protein X (HBx) (Peptide X) (pX)

3 entries

Hepatitis B virus genotype H (isolate United States/LAS2523/2002) (HBV-H)

Select_allDeselect_all
DPOL_HBVH1 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVH1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVH1 Protein X (HBx) (Peptide X) (pX)

3 entries

Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/1853Nic/1997) (HBV-H)

Select_allDeselect_all
DPOL_HBVH2 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVH2 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVH2 Protein X (HBx) (Peptide X) (pX)

3 entries

Orangutan hepatitis B virus (isolate Somad) (HBVoru)

Select_allDeselect_all
DPOL_HBVOR Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVOR Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
X_HBVOR Protein X (HBx) (Peptide X) (pX)

2 entries

Hepatitis B virus genotype D subtype adw (isolate United Kingdom/adyw/1979) (HBV-D)

Select_allDeselect_all
CAPSD_HBVD1 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
HBSAG_HBVD1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

2 entries

Hepatitis B virus genotype E (isolate Chimpanzee/Ch195/1999) (HBV-E)

Select_allDeselect_all
DPOL_HBVE3 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
X_HBVE3 Protein X (HBx) (Peptide X) (pX)

2 entries

Hepatitis B virus genotype F1 (isolate Argentina/sa11/2000) (HBV-F)

Select_allDeselect_all
DPOL_HBVF3 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HBVF3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

2 entries

Hepatitis B virus genotype F1 subtype adw4 (isolate El Salvador/1116Sal/1997) (HBV-F)

Select_allDeselect_all
DPOL_HBVF2 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
X_HBVF2 Protein X (HBx) (Peptide X) (pX)

2 entries

Hepatitis B virus genotype G (isolate United States/USG17/2002) (HBV-G)

Select_allDeselect_all
CAPSD_HBVG2 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
DPOL_HBVG2 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...

1 entry

Hepatitis B virus genotype A1 subtype adw2 (isolate Southern-Africa/Cai) (HBV-A)

HBSAG_HBVA1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype C subtype adr (isolate China/NC-1/1988) (HBV-C)

HBSAG_HBVC6 Small envelope protein (S glycoprotein) (S-HBsAg) (SHB) (Small S protein) (Small surface protein)

1 entry

Hepatitis B virus genotype G subtype adw2 (isolate United States/sf/1990) (HBV-G)

CAPSD_HBVG1 Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

1 entry

Woodchuck hepatitis B virus (isolate w64/pWS23) (WHV)

X_WHV6 Protein X (HBx) (Peptide X) (pX)