Molecular biology


Enveloped, spherical. Diameter from 60 to 300 nm.


Segmented Negative-stranded RNA linear genome, L segment is about 7,5 kb and S segment 3,5 kb.
Encodes for four proteins.


Both segments are ambisense. The viral RNA dependent RNA polymerase (L) binds to a promoter on each encapsidated segment, and transcribes a messager RNA. Transcription is terminated by a strong hairpin sequence at the end of each gene. mRNAs are capped, probably by L protein during synthesis.



  1. Virus attaches to host receptors though GP glycoprotein and is endocytosed into vesicles in the host cell by apoptotic mimicry.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the Z protein under the plasma membrane and buds, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The Z protein plays a role in inhibition of antiviral signaling through RIG-I

Matching UniProtKB/Swiss-Prot entries

87 entries grouped by protein (browse by keywords)

All proteins are shown (view only 66 complete proteome entries)

Pre-glycoprotein polyprotein GP complex

Select_all Deselect_all  
GLYC_LASSJLassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain
GLYC_LYCVALymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain
GLYC_TACVFTacaribe virus (strain Franze-Fernandez) (TCRV) reference strain
GLYC_ALLVPAllpahuayo mammarenavirus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)
GLYC_BCNVUBear Canyon mammarenavirus (isolate Mouse/United States/AV A0070039/2000) (BCNV)
GLYC_CHAVBChapare mammarenavirus (isolate Human/Bolivia/810419/2003)
GLYC_CPXVBCupixi mammarenavirus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)
GLYC_GTOVVGuanarito mammarenavirus (isolate Human/Venezuela/NH-95551/1990) (GTOV)
GLYC_IPPYVIppy mammarenavirus (isolate Rat/Central African Republic/Dak An B 188 d/1970) ...
GLYC_JUNINJunin mammarenavirus (JUNV) (Junn mammarenavirus)
GLYC_LASSGLassa virus (strain GA391) (LASV)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_LATVBLatino mammarenavirus (isolate Rat/Bolivia/MARU 1924/1965) (LATV)
GLYC_LYCVWLymphocytic choriomeningitis virus (strain WE) (LCMV)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_MACHUMachupo virus (MACV)
GLYC_MOBVCMobala mammarenavirus (isolate Rat/Central African Republic/Acar 3080/1983) ...
GLYC_MOPEIMopeia virus (MOPV)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_OLVVAOliveros mammarenavirus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)
GLYC_PARVPParana mammarenavirus (isolate Rat/Paraguay/12056/1965) (PARV) (Paran ...
GLYC_PIARVPichinde mammarenavirus (PICV) (Pichind mammarenavirus)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_PIRVVPirital mammarenavirus (isolate Rat/Venezuela/VAV-488/1995) (PIRV)
GLYC_SABVBSabia mammarenavirus (isolate Human/Brasil/SPH114202/1990) (SABV) (Sabi ...
GLYC_TACVTTacaribe virus (strain TRVL 11598) (TCRV)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_TACV5Tacaribe virus (strain V5) (TCRV)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_TACV7Tacaribe virus (strain V7) (TCRV)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_TAMVUTamiami mammarenavirus (isolate Rat/United States/W 10777/1964) (TAMV)
GLYC_WWAVUWhitewater Arroyo mammarenavirus (isolate Rat/United States/AV 9310135/1995) ...

RNA-directed RNA polymerase L (Protein L) (EC (Large structural protein) (Replicase) (Transcriptase)

Select_all Deselect_all  
L_LASSJLassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain
L_LYCVALymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain
L_TACVFTacaribe virus (strain Franze-Fernandez) (TCRV) reference strain
L_ALLVPAllpahuayo mammarenavirus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)
L_BCNVUBear Canyon mammarenavirus (isolate Mouse/United States/AV A0070039/2000) (BCNV)
L_CHAVBChapare mammarenavirus (isolate Human/Bolivia/810419/2003)
L_CPXVBCupixi mammarenavirus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)
L_GTOVVGuanarito mammarenavirus (isolate Human/Venezuela/NH-95551/1990) (GTOV)
L_IPPYVIppy mammarenavirus (isolate Rat/Central African Republic/Dak An B 188 d/1970) ...
L_JUNINJunin mammarenavirus (JUNV) (Junn mammarenavirus)
L_LATVBLatino mammarenavirus (isolate Rat/Bolivia/MARU 1924/1965) (LATV)
L_MACHUMachupo virus (MACV)
L_MOBVCMobala mammarenavirus (isolate Rat/Central African Republic/Acar 3080/1983) ...
L_OLVVAOliveros mammarenavirus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)
L_PARVPParana mammarenavirus (isolate Rat/Paraguay/12056/1965) (PARV) (Paran ...
L_PIRVVPirital mammarenavirus (isolate Rat/Venezuela/VAV-488/1995) (PIRV)
L_SABVBSabia mammarenavirus (isolate Human/Brasil/SPH114202/1990) (SABV) (Sabi ...
L_TAMVUTamiami mammarenavirus (isolate Rat/United States/W 10777/1964) (TAMV)
L_WWAVUWhitewater Arroyo mammarenavirus (isolate Rat/United States/AV 9310135/1995) ...

Nucleoprotein (Nucleocapsid protein) (Protein N)

Select_all Deselect_all  
NCAP_LASSJLassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain
NCAP_LYCVALymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain
NCAP_TACVFTacaribe virus (strain Franze-Fernandez) (TCRV) reference strain
NCAP_ALLVPAllpahuayo mammarenavirus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)
NCAP_BCNVUBear Canyon mammarenavirus (isolate Mouse/United States/AV A0070039/2000) (BCNV)
NCAP_CHAVBChapare mammarenavirus (isolate Human/Bolivia/810419/2003)
NCAP_CPXVBCupixi mammarenavirus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)
NCAP_GTOVVGuanarito mammarenavirus (isolate Human/Venezuela/NH-95551/1990) (GTOV)
NCAP_IPPYVIppy mammarenavirus (isolate Rat/Central African Republic/Dak An B 188 d/1970) ...
NCAP_JUNINJunin mammarenavirus (JUNV) (Junn mammarenavirus)
NCAP_LASSGLassa virus (strain GA391) (LASV)
NCAP_LATVBLatino mammarenavirus (isolate Rat/Bolivia/MARU 1924/1965) (LATV)
NCAP_LYCVWLymphocytic choriomeningitis virus (strain WE) (LCMV)
NCAP_MACHUMachupo virus (MACV)

Nucleoprotein (Protein N) (Nucleocapsid protein)

NCAP_MOBVCMobala mammarenavirus (isolate Rat/Central African Republic/Acar 3080/1983) ...
NCAP_MOPEIMopeia virus (MOPV)
NCAP_OLVVAOliveros mammarenavirus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)
NCAP_PARVPParana mammarenavirus (isolate Rat/Paraguay/12056/1965) (PARV) (Paran ...
NCAP_PIARVPichinde mammarenavirus (PICV) (Pichind mammarenavirus)
NCAP_PIRVVPirital mammarenavirus (isolate Rat/Venezuela/VAV-488/1995) (PIRV)
NCAP_SABVBSabia mammarenavirus (isolate Human/Brasil/SPH114202/1990) (SABV) (Sabi ...
NCAP_TAMVUTamiami mammarenavirus (isolate Rat/United States/W 10777/1964) (TAMV)
NCAP_WWAVUWhitewater Arroyo mammarenavirus (isolate Rat/United States/AV 9310135/1995) ...

RING finger protein Z (Protein Z) (Zinc-binding protein)

Select_all Deselect_all  
Z_LASSJLassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain
Z_LYCVALymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain
Z_TACVFTacaribe virus (strain Franze-Fernandez) (TCRV) reference strain
Z_ALLVPAllpahuayo mammarenavirus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)
Z_BCNVUBear Canyon mammarenavirus (isolate Mouse/United States/AV A0070039/2000) (BCNV)
Z_CHAVBChapare mammarenavirus (isolate Human/Bolivia/810419/2003)
Z_CPXVBCupixi mammarenavirus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)
Z_GTOVVGuanarito mammarenavirus (isolate Human/Venezuela/NH-95551/1990) (GTOV)
Z_IPPYVIppy mammarenavirus (isolate Rat/Central African Republic/Dak An B 188 d/1970) ...
Z_JUNINJunin mammarenavirus (JUNV) (Junn mammarenavirus)
Z_LATVBLatino mammarenavirus (isolate Rat/Bolivia/MARU 1924/1965) (LATV)
Z_MACHUMachupo virus (MACV)
Z_MOBVCMobala mammarenavirus (isolate Rat/Central African Republic/Acar 3080/1983) ...
Z_OLVVAOliveros mammarenavirus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)
Z_PARVPParana mammarenavirus (isolate Rat/Paraguay/12056/1965) (PARV) (Paran ...
Z_PIRVVPirital mammarenavirus (isolate Rat/Venezuela/VAV-488/1995) (PIRV)
Z_SABVBSabia mammarenavirus (isolate Human/Brasil/SPH114202/1990) (SABV) (Sabi ...
Z_TAMVUTamiami mammarenavirus (isolate Rat/United States/W 10777/1964) (TAMV)
Z_WWAVUWhitewater Arroyo mammarenavirus (isolate Rat/United States/AV 9310135/1995) ...