Arenaviridae (taxid:11617)
VIRION
Enveloped, spherical. Diameter from 60 to 300 nm.
GENOME
Segmented Negative-stranded RNA linear genome, L segment is about 7,5 kb and S segment 3,5 kb.
Encodes for four proteins.
GENE EXPRESSION
Both segments are ambisens. The viral RNA dependent RNA polymerase (L) binds to a promoter on each encapsidated segment, and transcribes a messager RNA. Transcription is terminated by a strong hairpin sequence at the end of each gene. mRNAs are capped, probably by L protein during synthesis.
ENZYMES
REPLICATION
CYTOPLASM
- Virus attaches to host receptors though GP glycoprotein and is endocytosed into vesicles in the host cell by apoptotic mimicry.
- Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released in the cytoplasm.
- Sequential transcription, viral mRNAs are capped in the cytoplasm.
- Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
- The ribonucleocapsid interacts with the Z protein under the plasma membrane and buds, releasing the virion.
Host-virus interaction
Inhibition of host Interferon induction
The Z protein plays a role in inhibition of antiviral signaling through RIG-I
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)92 entries grouped by protein
27 entries
Pre-glycoprotein polyprotein GP complex (Pre-GP-C)
21 entries
RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) (Transcriptase)
1 entry
Putative membrane protein
24 entries
Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
19 entries
RING finger protein Z (Protein Z) (Zinc-binding protein)
Alethinophid 1 reptarenavirus (isolate AlRrV1/Boa/USA/BC/2009) taxid:1223562
| Protein | ModelArchive |
| Glycoprotein | ma-jd-viral-51469 |
| Nucleoprotein (Nucleocapsid protein) (Protein N) | ma-jd-viral-04945 |
| Putative membrane protein | ma-jd-viral-62943 |
Allpahuayo mammarenavirus (isolate Rat/Peru/CLHP-2472/1997) taxid:144752
| Protein | ModelArchive |
| Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N) | ma-jd-viral-04957 |
| Pre-glycoprotein polyprotein GP complex (Pre-GP-C) | ma-jd-viral-51274 |
Bear Canyon mammarenavirus (isolate Mouse/United States/AV A0070039/2000) taxid:3052298
CAS virus taxid:1223561
| Protein | ModelArchive |
| Glycoprotein | ma-jd-viral-51468 |
| Nucleoprotein | ma-jd-viral-04963 |
| Z protein | ma-jd-viral-62945 |
Chapare mammarenavirus (isolate Human/Bolivia/810419/2003) taxid:3052302
Lunk virus NKS-1 taxid:1134579
| Protein | ModelArchive |
| Glycoprotein | ma-jd-viral-51287 |
| Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N) | ma-jd-viral-04941 |
| Z protein | ma-jd-viral-04503 |
Lymphocytic choriomeningitis virus (strain Armstrong) taxid:11624
Machupo virus taxid:3052317
Mammarenavirus choriomeningitidis taxid:3052303
| Protein | ModelArchive |
| Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N) | ma-jd-viral-04958 |
Mammarenavirus gairoense taxid:3052306
| Protein | ModelArchive |
| Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N) | ma-jd-viral-04948 |
| Pre-glycoprotein polyprotein GP complex (Pre-GP-C) | ma-jd-viral-51288 |
| Z protein | ma-jd-viral-04513 |
Mammarenavirus lujoense taxid:3052314
| Protein | ModelArchive |
| Glycoprotein | ma-jd-viral-51291 |
| Multifunctional matrix-like protein (Z protein) | ma-jd-viral-04509 |
| Nucleocapsid protein (Nucleoprotein) | ma-jd-viral-04960 |
Mammarenavirus lunaense taxid:3052315
Mammarenavirus marientalense taxid:3052318
Mammarenavirus merinoense taxid:3052319
| Protein | ModelArchive |
| Nucleoprotein (Nucleocapsid protein) | ma-jd-viral-04939 |
| Pre-glycoprotein polyprotein GP complex (Pre-GP-C) | ma-jd-viral-51282 |
| Z protein | ma-jd-viral-04507 |
Mammarenavirus okahandjaense taxid:3052321
Mammarenavirus wenzhouense taxid:3052330
| Protein | ModelArchive |
| Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N) | ma-jd-viral-04940 |
| Pre-glycoprotein polyprotein GP complex (Pre-GP-C) | ma-jd-viral-51276 |
| Z protein | ma-jd-viral-04514 |
Mopeia Lassa virus reassortant 29 taxid:300180
| Protein | ModelArchive |
| Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N) | ma-jd-viral-04938 |
| Pre-glycoprotein polyprotein GP complex (Pre-GP-C) | ma-jd-viral-51284 |
| Z protein | ma-jd-viral-04502 |
Morogoro mammarenavirus taxid:573900
Pichinde mammarenavirus taxid:3052300
| Protein | ModelArchive |
| RING finger protein Z (Protein Z) (Zinc-binding protein) | ma-jd-viral-04522 |
Pirital mammarenavirus (isolate Rat/Venezuela/VAV-488/1995) taxid:3052324
| Protein | ModelArchive |
| RING finger protein Z (Protein Z) (Zinc-binding protein) | ma-jd-viral-04521 |
ROUT virus taxid:1303019
| Protein | ModelArchive |
| Glycoprotein | ma-jd-viral-51470 |
| Nucleocapsid protein | ma-jd-viral-04956 |
| Z protein | ma-jd-viral-62947 |
Tamiami mammarenavirus (isolate Rat/United States/W 10777/1964) taxid:3052329
| Protein | ModelArchive |
| RING finger protein Z (Protein Z) (Zinc-binding protein) | ma-jd-viral-04520 |
University of Helsinki virus taxid:1382279
| Protein | ModelArchive |
| Glycoprotein | ma-jd-viral-51471 |
| Nucleoprotein | ma-jd-viral-04942 |
| Z protein | ma-jd-viral-62944 |
Whitewater Arroyo mammarenavirus (isolate Rat/United States/AV 9310135/1995) taxid:3052331
| Protein | ModelArchive |
| RING finger protein Z (Protein Z) (Zinc-binding protein) | ma-jd-viral-04516 |