Molecular biology


Enveloped, spherical. Diameter from 60 to 300 nm.


Segmented Negative-stranded RNA linear genome, L segment is about 7,5 kb and S segment 3,5 kb.
Encodes for four proteins.


Both segments are ambisense. The viral RNA dependent RNA polymerase (L) binds to a promoter on each encapsidated segment, and transcribes a messager RNA. Transcription is terminated by a strong hairpin sequence at the end of each gene. mRNAs are capped, probably by L protein during synthesis.



  1. Virus attaches to host receptors though GP glycoprotein and is endocytosed into vesicles in the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the Z protein under the plasma membrane and buds, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The Z protein plays a role in inhibition of antiviral signaling through RIG-I

Matching UniProtKB/Swiss-Prot entries

87 entries grouped by protein (browse by keywords)

All proteins are shown (view only 66 complete proteome entries)

Pre-glycoprotein polyprotein GP complex

Select_all Deselect_all  
GLYC_LASSJLassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain
GLYC_LYCVALymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain
GLYC_TACVFTacaribe virus (strain Franze-Fernandez) (TCRV) reference strain
GLYC_ALLVPAllpahuayo virus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)
GLYC_BCNVUBear canyon virus (isolate Mouse/United States/AV A0070039/2000) (BCNV)
GLYC_CHAVBChapare virus (isolate Human/Bolivia/810419/2003)
GLYC_CPXVBCupixi virus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)
GLYC_GTOVVGuanarito virus (isolate Human/Venezuela/NH-95551/1990) (GTOV)
GLYC_IPPYVIppy virus (isolate Rat/Central African Republic/Dak An B 188 d/1970) (IPPYV)
GLYC_JUNINJunin arenavirus (JUNV)
GLYC_LASSGLassa virus (strain GA391) (LASV)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_LATVBLatino virus (isolate Rat/Bolivia/MARU 1924/1965) (LATV)
GLYC_LYCVWLymphocytic choriomeningitis virus (strain WE) (LCMV)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_MACHUMachupo virus (MACV)
GLYC_MOBVCMobala virus (isolate Rat/Central African Republic/Acar 3080/1983) (MOBV)
GLYC_MOPEIMopeia virus (MOPV)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_OLVVAOliveros virus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)
GLYC_PARVPParana virus (isolate Rat/Paraguay/12056/1965) (PARV)
GLYC_PIARVPichinde arenavirus (PICV)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_PIRVVPirital virus (isolate Rat/Venezuela/VAV-488/1995) (PIRV)
GLYC_SABVBSabia virus (isolate Human/Brasil/SPH114202/1990) (SABV)
GLYC_TACVTTacaribe virus (strain TRVL 11598) (TCRV)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_TACV5Tacaribe virus (strain V5) (TCRV)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_TACV7Tacaribe virus (strain V7) (TCRV)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_TAMVUTamiami virus (isolate Rat/United States/W 10777/1964) (TAMV)
GLYC_WWAVUWhitewater arroyo virus (isolate Rat/United States/AV 9310135/1995) (WWAV)

RNA-directed RNA polymerase L (Protein L) (EC (Large structural protein) (Replicase) (Transcriptase)

Select_all Deselect_all  
L_LASSJLassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain
L_LYCVALymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain
L_TACVFTacaribe virus (strain Franze-Fernandez) (TCRV) reference strain
L_ALLVPAllpahuayo virus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)
L_BCNVUBear canyon virus (isolate Mouse/United States/AV A0070039/2000) (BCNV)
L_CHAVBChapare virus (isolate Human/Bolivia/810419/2003)
L_CPXVBCupixi virus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)
L_GTOVVGuanarito virus (isolate Human/Venezuela/NH-95551/1990) (GTOV)
L_IPPYVIppy virus (isolate Rat/Central African Republic/Dak An B 188 d/1970) (IPPYV)
L_JUNINJunin arenavirus (JUNV)
L_LATVBLatino virus (isolate Rat/Bolivia/MARU 1924/1965) (LATV)
L_MACHUMachupo virus (MACV)
L_MOBVCMobala virus (isolate Rat/Central African Republic/Acar 3080/1983) (MOBV)
L_OLVVAOliveros virus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)
L_PARVPParana virus (isolate Rat/Paraguay/12056/1965) (PARV)
L_PIRVVPirital virus (isolate Rat/Venezuela/VAV-488/1995) (PIRV)
L_SABVBSabia virus (isolate Human/Brasil/SPH114202/1990) (SABV)
L_TAMVUTamiami virus (isolate Rat/United States/W 10777/1964) (TAMV)
L_WWAVUWhitewater arroyo virus (isolate Rat/United States/AV 9310135/1995) (WWAV)

Nucleoprotein (Nucleocapsid protein) (Protein N)

Select_all Deselect_all  
NCAP_LASSJLassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain
NCAP_LYCVALymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain
NCAP_TACVFTacaribe virus (strain Franze-Fernandez) (TCRV) reference strain
NCAP_ALLVPAllpahuayo virus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)
NCAP_BCNVUBear canyon virus (isolate Mouse/United States/AV A0070039/2000) (BCNV)
NCAP_CHAVBChapare virus (isolate Human/Bolivia/810419/2003)
NCAP_CPXVBCupixi virus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)
NCAP_GTOVVGuanarito virus (isolate Human/Venezuela/NH-95551/1990) (GTOV)
NCAP_IPPYVIppy virus (isolate Rat/Central African Republic/Dak An B 188 d/1970) (IPPYV)
NCAP_JUNINJunin arenavirus (JUNV)
NCAP_LASSGLassa virus (strain GA391) (LASV)
NCAP_LATVBLatino virus (isolate Rat/Bolivia/MARU 1924/1965) (LATV)
NCAP_LYCVWLymphocytic choriomeningitis virus (strain WE) (LCMV)
NCAP_MACHUMachupo virus (MACV)

Nucleoprotein (Protein N) (Nucleocapsid protein)

NCAP_MOBVCMobala virus (isolate Rat/Central African Republic/Acar 3080/1983) (MOBV)
NCAP_MOPEIMopeia virus (MOPV)
NCAP_OLVVAOliveros virus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)
NCAP_PARVPParana virus (isolate Rat/Paraguay/12056/1965) (PARV)
NCAP_PIARVPichinde arenavirus (PICV)
NCAP_PIRVVPirital virus (isolate Rat/Venezuela/VAV-488/1995) (PIRV)
NCAP_SABVBSabia virus (isolate Human/Brasil/SPH114202/1990) (SABV)
NCAP_TAMVUTamiami virus (isolate Rat/United States/W 10777/1964) (TAMV)
NCAP_WWAVUWhitewater arroyo virus (isolate Rat/United States/AV 9310135/1995) (WWAV)

RING finger protein Z (Protein Z) (Zinc-binding protein)

Select_all Deselect_all  
Z_LASSJLassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain
Z_LYCVALymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain
Z_TACVFTacaribe virus (strain Franze-Fernandez) (TCRV) reference strain
Z_ALLVPAllpahuayo virus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)
Z_BCNVUBear canyon virus (isolate Mouse/United States/AV A0070039/2000) (BCNV)
Z_CHAVBChapare virus (isolate Human/Bolivia/810419/2003)
Z_CPXVBCupixi virus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)
Z_GTOVVGuanarito virus (isolate Human/Venezuela/NH-95551/1990) (GTOV)
Z_IPPYVIppy virus (isolate Rat/Central African Republic/Dak An B 188 d/1970) (IPPYV)
Z_JUNINJunin arenavirus (JUNV)
Z_LATVBLatino virus (isolate Rat/Bolivia/MARU 1924/1965) (LATV)
Z_MACHUMachupo virus (MACV)
Z_MOBVCMobala virus (isolate Rat/Central African Republic/Acar 3080/1983) (MOBV)
Z_OLVVAOliveros virus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)
Z_PARVPParana virus (isolate Rat/Paraguay/12056/1965) (PARV)
Z_PIRVVPirital virus (isolate Rat/Venezuela/VAV-488/1995) (PIRV)
Z_SABVBSabia virus (isolate Human/Brasil/SPH114202/1990) (SABV)
Z_TAMVUTamiami virus (isolate Rat/United States/W 10777/1964) (TAMV)
Z_WWAVUWhitewater arroyo virus (isolate Rat/United States/AV 9310135/1995) (WWAV)