Inhibition of host complement factors by virus

The complement system is a major non-specific mechanism of humoral immunity. The activation of complement involves the sequential proteolyis of proteins to generate enzymes with catalytic activities. The biological functions of the complement include opsonization, inflammation, lysis of immune complexes, or enhancement of the humoral immune response.

Members of the herpesvirus, orthopoxvirus and retrovirus families mimic or interact with complement regulatory proteins to block complement activation and neutralization of virus particles. For example, vaccinia and variola viruses encode secreted proteins that block C3 convertase assembly. Influenza A virus instead blocks the complement pathway via M1 protein interacting with and inhibiting host C1qA protein.

Matching UniProtKB/Swiss-Prot entries

130 entries grouped by protein (browse by keywords)

All proteins are shown (view only 60 complete proteome entries)

Capsid polyprotein VP90

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CAPSD_TASV1Turkey astrovirus 1 (TAstV-1) reference strain
CAPSD_ANV1Avian nephritis virus 1 (ANV-1)
CAPSD_TASV2Turkey astrovirus 2 (TAstV-2)

Envelope glycoprotein C

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GC_EHV1BEquine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain

Envelope glycoprotein C (gC) (Glycoprotein 13)

GC_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GC_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GC_VZVDVaricella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain

Envelope glycoprotein C (gC) (Glycoprotein V) (gpV)

GC_BHV1CBovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine ...

Envelope glycoprotein C homolog (Glycoprotein GIII)

GC_EHV1DEquine herpesvirus 1 (strain Kentucky D) (EHV-1) (Equine abortion virus)

Envelope glycoprotein C (gC) (Glycoprotein 13)

GC_EHV4Equine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)

Envelope glycoprotein C (Glycoprotein 13)

GC_HHV1KHuman herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
GC_HHV23Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)
GC_HHV2GHuman herpesvirus 2 (strain G) (HHV-2) (Human herpes simplex virus 2)

Envelope glycoprotein C (Glycoprotein F)

GC_SUHVFSuid herpesvirus 1 (strain Indiana-Funkhauser / Becker) (SuHV-1) (Pseudorabies ...

Envelope glycoprotein C homolog (Glycoprotein GIII)

Matrix protein 1 (M1)

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M1_I96A0Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
M1_I34A1Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain
M1_I80A2Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7) reference strain
M1_I80A8Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2) reference strain
M1_I68A0Influenza A virus (strain A/Aichi/2/1968 H3N2)
M1_I60A0Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)
M1_I79A0Influenza A virus (strain A/Bangkok/1/1979 H3N2)
M1_I89A2Influenza A virus (strain A/Beijing/353/1989 H3N2)
M1_I75A0Influenza A virus (strain A/Beijing/39/1975 H3N2)
M1_I77AAInfluenza A virus (strain A/Brazil/11/1978 H1N1)
M1_I18A0Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus ...
M1_I77AGInfluenza A virus (strain A/Budgerigar/Hokkaido/1/1977 H4N6)
M1_I02A0Influenza A virus (strain A/Chicken/Brescia/1902 H7N7)
M1_I97A0Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)
M1_I02A2Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
M1_I02A3Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)
M1_I01A3Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
M1_I02A5Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
M1_I01A2Influenza A virus (strain A/Chicken/Hong Kong/FY150/2001 H5N1 genotype D)
M1_I02A6Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
M1_I01A1Influenza A virus (strain A/Chicken/Hong Kong/YU562/2001 H5N1 genotype B)
M1_I83A5Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)
M1_I83A6Influenza A virus (strain A/Chicken/Pennsylvania/1370/1983 H5N2)
M1_I59A0Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
M1_I03A1Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
M1_I85A3Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)
M1_I000FInfluenza A virus (strain A/Chicken/Weybridge H7N7) (Influenza A virus (strain ...
M1_I83A1Influenza A virus (strain A/Chile/1/1983 H1N1)
M1_I96A3Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)
M1_I56A1Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)
M1_I56A2Influenza A virus (strain A/Duck/England/1/1956 H11N6)
M1_I49A1Influenza A virus (strain A/Duck/Germany/1949 H10N7)
M1_I80A6Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)
M1_I00A0Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
M1_I69A0Influenza A virus (strain A/England/878/1969 H3N2)
M1_I91A0Influenza A virus (strain A/Equine/Alaska/1/1991 H3N8)
M1_I89A7Influenza A virus (strain A/Equine/Jillin/1/1989 H3N8)
M1_I81A2Influenza A virus (strain A/Equine/Kentucky/1/1981)
M1_I86A2Influenza A virus (strain A/Equine/Kentucky/2/1986 H3N8)
M1_I77A9Influenza A virus (strain A/Equine/New Market/1/1977 H7N7)
M1_I79A6Influenza A virus (strain A/Equine/New Market/1979 H3N8)
M1_I56A3Influenza A virus (strain A/Equine/Prague/1/1956 H7N7)
M1_I86A3Influenza A virus (strain A/Equine/Tennessee/5/1986 H3N8)
M1_I50A0Influenza A virus (strain A/Fort Warren/1/1950 H1N1)
M1_I34A0Influenza A virus (strain A/Fowl plague virus/Rostock/8/1934 H7N1)
M1_I05A1Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
M1_I79A7Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)
M1_I79A8Influenza A virus (strain A/Gull/Maryland/1815/1979 H13N6)
M1_I78AFInfluenza A virus (strain A/Gull/Maryland/1824/1978 H13N6)
M1_I77AFInfluenza A virus (strain A/Gull/Maryland/704/1977 H13N6)
M1_I80ACInfluenza A virus (strain A/Gull/Massachusetts/26/1980 H13N6)
M1_I80ADInfluenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)
M1_I36A0Influenza A virus (strain A/Henry/1936 H1N1)
M1_I40A0Influenza A virus (strain A/Hickox/1940 H1N1)
M1_I68A4Influenza A virus (strain A/Hong Kong/1/1968 H3N2)
M1_I97A1Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
M1_I03A0Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
M1_I83A8Influenza A virus (strain A/Hong Kong/5/1983 H3N2)
M1_I80AAInfluenza A virus (strain A/India/6263/1980 H1N1)
M1_I57A0Influenza A virus (strain A/Japan/305/1957 H2N2)
M1_I68A5Influenza A virus (strain A/Korea/426/1968 H2N2)
M1_I57A2Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)
M1_I57A1Influenza A virus (strain A/Leningrad/134/1957 H2N2)
M1_I57A3Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)
M1_I54A2Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)
M1_I78A3Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)
M1_I71A1Influenza A virus (strain A/Memphis/1/1971 H3N2)
M1_I72A4Influenza A virus (strain A/Memphis/101/1972 H3N2)
M1_I72A3Influenza A virus (strain A/Memphis/102/1972 H3N2)
M1_I76A6Influenza A virus (strain A/Memphis/110/1976 H3N2)
M1_I78A8Influenza A virus (strain A/Memphis/18/1978 H3N2)
M1_I78A7Influenza A virus (strain A/Memphis/2/1978 H3N2)
M1_I80A4Influenza A virus (strain A/Memphis/4/1980 H3N2)
M1_I88A3Influenza A virus (strain A/Memphis/8/1988 H3N2)
M1_I00A1Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)
M1_I68A6Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus ...
M1_I82A9Influenza A virus (strain A/Philippines/2/1982 H3N2)
M1_I73A5Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)
M1_I70A0Influenza A virus (strain A/Qu/7/1970 H3N2)
M1_I06A0Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)
M1_I72A5Influenza A virus (strain A/Shearwater/Australia/1972 H6N5)
M1_I01A0Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
M1_I02A4Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)
M1_I57A5Influenza A virus (strain A/Singapore/1/1957 H2N2)
M1_I37A0Influenza A virus (strain A/Swine/29/1937 H1N1)
M1_I77A4Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)
M1_I82A7Influenza A virus (strain A/Swine/Hong Kong/127/1982 H3N2)
M1_I30A0Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)
M1_I88A5Influenza A virus (strain A/Swine/Iowa/17672/1988 H1N1)
M1_I54A1Influenza A virus (strain A/Swine/May/1954 H1N1)
M1_I85A4Influenza A virus (strain A/Swine/Netherlands/12/1985 H1N1)
M1_I81A4Influenza A virus (strain A/Swine/Ontario/2/1981 H1N1)
M1_I77ACInfluenza A virus (strain A/Swine/Tennessee/24/1977 H1N1)
M1_I61A1Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)
M1_I67A2Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)
M1_I67A0Influenza A virus (strain A/Tokyo/3/1967 H2N2)
M1_I83A4Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)
M1_I78ACInfluenza A virus (strain A/Turkey/Minnesota/501/1978 H6N8)
M1_I68A3Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)
M1_I66A0Influenza A virus (strain A/Turkey/Ontario/7732/1966 H5N9)
M1_I71A2Influenza A virus (strain A/Turkey/Oregon/1971 H7N3)
M1_I66A1Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)
M1_I72A2Influenza A virus (strain A/Udorn/307/1972 H3N2)
M1_I51A0Influenza A virus (strain A/USA:Albany/12/1951 H1N1)
M1_I45A0Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)
M1_I43A0Influenza A virus (strain A/USA:Iowa/1943 H1N1)
M1_I96A2Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)
M1_I35A3Influenza A virus (strain A/USA:Phila/1935 H1N1)
M1_I77ABInfluenza A virus (strain A/USSR/90/1977 H1N1)
M1_I33A0Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain ...
M1_I88A7Influenza A virus (strain A/Wisconsin/3523/1988 H1N1)
M1_I000XInfluenza A virus (strain A/X-31 H3N2)

Complement control protein (KCP)

ORF4_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Genome polyprotein

POLG_MCFAMosquito cell fusing agent (CFA flavivirus)

Complement control protein C3 (28 kDa protein) (Secretory protein 35) (Protein C3) (VCP)

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VCP_VACCWVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain
VCP_VACCCVaccinia virus (strain Copenhagen) (VACV)