Pore-mediated penetration of viral genome into host cell



Some non-enveloped viruses inject their genome into the host cytoplasm through creation of a pore in the host membrane. This is mediated by a viral pore-forming peptide associated with the viral capsid.

The icosahedric capsid of picornaviridae is able to create a pore either at plasma or endosomal membrane to inject their genomic RNA.

Papillomaviridae and polyomaviridae seem to enter the endoplasmic reticulum where their icosahedric capsid is disassembled, releasing pore forming proteins that induce injection of genomic DNA into cell cytoplasm.

Prokaryotic viruses such as caudovirales eject their genome into the host cytoplasm through a complex ejection apparatus. This mechanism often involves pore formation in the host membrane(s).

Matching UniProtKB/Swiss-Prot entries

48 entries grouped by protein (browse by keywords)

Tail knob protein gp9 (Distal tube protein) (Gene product 9) (gp9) (Protein p9)

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DIT9_BPNFBacillus phage Nf (Bacteriophage Nf) reference strain

Tail knob protein gp9 (Distal tube protein) (Gene product 9) (gp9) (Protein p9) (Tail protein)

DIT9_BPPH2Bacillus phage phi29 (Bacteriophage phi-29) reference strain
DIT9_BPB03Bacillus phage B103 (Bacteriophage B103)
DIT9_BPPZABacillus phage PZA (Bacteriophage PZA)

Tail needle protein gp26 (Head completion protein) (Packaged DNA stabilization protein) (Tail accessory factor gp26)


NEEDL_BPP22Salmonella phage P22 (Bacteriophage P22) reference strain

Genome polyprotein

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POLG_HRV8AHuman rhinovirus A serotype 89 (strain 41467-Gallo) (HRV-89) reference strain
POLG_POL1MPoliovirus type 1 (strain Mahoney) reference strain
POLG_BOVEVBovine enterovirus (strain VG-5-27) (BEV)
POLG_CX16GCoxsackievirus A16 (strain G-10)
POLG_CX16TCoxsackievirus A16 (strain Tainan/5079/98)
POLG_CXA21Coxsackievirus A21 (strain Coe)
POLG_CXA24Coxsackievirus A24 (strain EH24/70)
POLG_CXA9Coxsackievirus A9 (strain Griggs)
POLG_CXB1JCoxsackievirus B1 (strain Japan)
POLG_CXB2OCoxsackievirus B2 (strain Ohio-1)
POLG_CXB3NCoxsackievirus B3 (strain Nancy)
POLG_CXB3WCoxsackievirus B3 (strain Woodruff)
POLG_CXB4ECoxsackievirus B4 (strain E2)
POLG_CXB4JCoxsackievirus B4 (strain JVB / Benschoten / New York/51)
POLG_CXB5PCoxsackievirus B5 (strain Peterborough / 1954/UK/85)
POLG_CXB6SCoxsackievirus B6 (strain Schmitt)
POLG_EC01FEchovirus 1 (strain Human/Egypt/Farouk/1951) (E-1)
POLG_EC11GEchovirus 11 (strain Gregory)
POLG_EC12TEchovirus 12 (strain Travis)
POLG_EC30BEchovirus 30 (strain Bastianni)
POLG_EC05NEchovirus 5 (strain Noyce)
POLG_EC06CEchovirus 6 (strain Charles)
POLG_EC09BEchovirus 9 (strain Barty)
POLG_EC09HEchovirus 9 (strain Hill)
POLG_HE701Human enterovirus 70 (strain J670/71) (EV 70)
POLG_HE71MHuman enterovirus 71 (strain 7423/MS/87) (Ev 71)
POLG_HE71BHuman enterovirus 71 (strain BrCr) (Ev 71)
POLG_HRV14Human rhinovirus 14 (HRV-14)
POLG_HRV16Human rhinovirus 16 (HRV-16)
POLG_HRV1AHuman rhinovirus 1A (HRV-1A)
POLG_HRV1BHuman rhinovirus 1B (HRV-1B)
POLG_HRV2Human rhinovirus 2 (HRV-2)
POLG_HRV3Human rhinovirus 3 (HRV-3)
POLG_POL1SPoliovirus type 1 (strain Sabin)
POLG_POL2LPoliovirus type 2 (strain Lansing)
POLG_POL2WPoliovirus type 2 (strain W-2)
POLG_POL32Poliovirus type 3 (strain 23127)
POLG_POL3LPoliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)
POLG_PEV9UPorcine enterovirus 9 (strain UKG/410/73)
POLG_SVDVHSwine vesicular disease virus (strain H/3 '76) (SVDV)
POLG_SVDVUSwine vesicular disease virus (strain UKG/27/72) (SVDV)

Spike protein (Baseplate assembly protein gpV) (Gene V protein) (GpV)


SPIKE_BPP2Escherichia phage P2 (Bacteriophage P2) reference strain

Probable tape measure protein (Tail protein pb2)


TMP_BPT5Escherichia phage T5 (Enterobacteria phage T5) reference strain