Parvoviridae (taxid:10780)

VIRION

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Non-enveloped, round, T=1 icosahedral symmetry, 18-26 nm in diameter. The capsid consists of 60 copies of CP protein.
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GENOME

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Linear, ssDNA genome of about 4 to 6 kb in size.
The genome is replicated through rolling-hairpin mechanism.

GENE EXPRESSION

Host proteins transcribe the genome into mRNAs. Depending on the virus there can be one (Erythrovirus and Iteravirus), two (Densovirus and Brevidensovirus) or three (Dependovirus) promoters for mRNA transcription. Alternative splicing allows expression of both structural and non-structural proteins. Leaky scanning is used as well by densoviruses.

ENZYMES

REPLICATION

NUCLEAR

  1. Attachement to host receptors initiates clathrin-mediated endocytosis of the virion into the host cell.
  2. The virion penetrates into the cytoplasm via permeabilization of host endosomal membrane.
  3. Microtubular transport of the virion toward the nucleus.
  4. The viral ssDNA genome penetrates into the nucleus.
  5. The ssDNA is converted into dsDNA by cellular proteins.
  6. dsDNA transcription gives rise to viral mRNAs when host cell enters S phase and translated to produce viral proteins.
  7. Replication occurs through rolling-hairpin mechanism, with NS1 endonuclease binding covalently to the 5' genomic end.
  8. Individual ssDNA genomes are excised from replication concatemers by a process called junction resolution.
  9. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated to form new virions that are released by cell lysis.

Host-virus interaction

Apoptosis modulation

Parvoviruses infection induces host cell death, which is often directly associated with disease outcomes. Apoptosis is the major form of cell death induced by parvovirus infection, mostly associated with caspases activation. However, necrosis, has also been reported during infection of the minute virus of mice, parvovirus H-1 and bovine parvovirus.

Cell-cycle modulation

Many parvoviruses induce G2/M checkpoint arrest.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

74 entries grouped by strain

6 entries

Adeno-associated virus 2 (isolate Srivastava/1982) (AAV-2) reference strain

Select_allDeselect_all
REP68_AAV2S Protein Rep68 (EC 3.6.4.12)
CAPSD_AAV2S Capsid protein VP1
REP78_AAV2S Protein Rep78
REP40_AAV2S Protein Rep40 (EC 3.6.4.12)
REP52_AAV2S Protein Rep52
AAP_AAV2S Assembly activating protein AAP

5 entries

Human parvovirus B19 (strain HV) (HPV B19) reference strain

Select_allDeselect_all
CAPSD_PAVHV Minor capsid protein VP1 (EC 3.1.1.4) (Coat protein VP1)
NS1_PAVHV Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...
11K_PAVHV Host-modulation protein 11K (Host-modulation protein of 11 kDa)
75K_PAVHV Uncharacterized protein 7.5K (Uncharacterized protein of 7.5 kDa)
X_PAVHV Uncharacterized protein X

4 entries

Aleutian mink disease parvovirus (strain G) (ADV) reference strain

Select_allDeselect_all
NS1_ADVG Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (Non-structural protein 1) (Non-structural ...
CAPSD_ADVG Capsid protein VP1
NS2_ADVG Non-structural protein NS2
NS3_ADVG Non-structural protein NS3

4 entries

Junonia coenia densovirus (isolate pBRJ/1990) (JcDNV) reference strain

Select_allDeselect_all
NS1_JDNVP Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (Non-structural protein 1) (Non-structural ...
CAPSD_JDNVP Capsid protein VP1 (Coat protein VP1) (Structural protein VP1)
VNS2_JDNVP Putative non-structural protein NS2 (ORF3)
VNS3_JDNVP Putative non-structural protein NS3 (ORF4)

3 entries

Aedes albopictus densovirus (isolate Boublik/1994) (AalDNV) reference strain

Select_allDeselect_all
NS1_AADNV Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (Non-structural protein 1) (Non-structural ...
CAPSD_AADNV Capsid protein VP1/VP2 (Coat protein VP1/VP2)
NS2_AADNV Non-structural protein NS2 (Non-capsid protein NS-2) (NCVP2)

3 entries

Bovine parvovirus 1 (BPV-1) reference strain

Select_allDeselect_all
NS1_PAVBP Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (Non-structural protein 1) (Non-structural ...
CAPSD_PAVBP Minor capsid protein VP1 (EC 3.1.1.4)
NP1_PAVBP Non-structural protein NP-1 (NP1)

3 entries

Murine minute virus (strain MVM prototype) (MVM) (Murine minute virus (strain MVM(p))) reference strain

Select_allDeselect_all
NS1_MUMIP Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...
CAPSD_MUMIP Capsid protein VP1 (Coat protein VP1)
NS2_MUMIP Non-structural protein NS2

3 entries

Primate bocaparvovirus 1 (strain Human bocavirus 1 type 1) (HBoV1) (Human bocavirus type 1) reference strain

Select_allDeselect_all
NS1_HBOC1 Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (Non-structural protein 1) (Non-structural ...
CAPSD_HBOC1 Minor capsid protein VP1 (EC 3.1.1.4)
NP1_HBOC1 Non-structural protein NP-1 (NP1)

4 entries

Diatraea saccharalis densovirus (DsDNV)

Select_allDeselect_all
NS1_DSDNV Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (Non-structural protein 1) (Non-structural ...
CAPSD_DSDNV Capsid protein VP1 (Coat protein VP1) (Structural protein VP1)
VNS3_DSDNV Non-structural protein NS3
VNS2_DSDNV Non-structural protein NS2

3 entries

Bombyx mori densovirus (BmDNV) (Bombyx densonucleosis virus)

Select_allDeselect_all
NS1_BMDNV Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (Non-structural protein 1) (Non-structural ...
VNS1_BMDNV Putative non-structural protein (ORF1)
VNS3_BMDNV Putative non-structural protein (ORF3)

3 entries

Human bocavirus 2 (HBoV2) (Human bocavirus type 2)

Select_allDeselect_all
NS1_HBOC2 Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (Non-structural protein 1) (Non-structural ...
CAPSD_HBOC2 Minor capsid protein VP1 (EC 3.1.1.4)
NP1_HBOC2 Non-structural protein NP-1 (NP1)

3 entries

Human bocavirus 3 (HBoV3) (Adelavirus W471)

Select_allDeselect_all
CAPSD_HBOC3 Minor capsid protein VP1 (EC 3.1.1.4)
NS1_HBOC3 Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (Non-structural protein 1) (Non-structural ...
NP1_HBOC3 Non-structural protein NP-1 (NP1)

3 entries

Human bocavirus 4 (HBoV4) (Human bocavirus type 4)

Select_allDeselect_all
NS1_HBOC4 Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (Non-structural protein 1) (Non-structural ...
CAPSD_HBOC4 Minor capsid protein VP1 (EC 3.1.1.4)
NP1_HBOC4 Non-structural protein NP-1 (NP1)

2 entries

Aedes densonucleosis virus (strain GKV 002 002) (Aedes densovirus)

Select_allDeselect_all
NS1_AEDEV Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (Non-structural protein 1) (Non-structural ...
CAPSD_AEDEV Capsid protein VP1/VP2 (Coat protein VP1/VP2)

2 entries

Canine parvovirus type 2 (isolate Dog/United States/CPV-N/1978) (CPV-2)

Select_allDeselect_all
NS1_PAVCN Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...
CAPSD_PAVCN Capsid protein VP1 (Coat protein VP1)

2 entries

Feline panleukopenia virus (strain 193) (FPV)

Select_allDeselect_all
CAPSD_FPV19 Capsid protein VP1 (Coat protein VP1)
NS1_FPV19 Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...

2 entries

Hamster parvovirus H1

Select_allDeselect_all
NS1_PAVHH Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...
CAPSD_PAVHH Capsid protein VP1 (Coat protein VP1)

2 entries

Human parvovirus B19 (isolate AU) (HPV B19)

Select_allDeselect_all
NS1_PAVHU Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...
CAPSD_PAVHU Minor capsid protein VP1 (EC 3.1.1.4) (Coat protein VP1)

2 entries

Mink enteritis virus (strain Abashiri) (MEV)

Select_allDeselect_all
NS1_MEVA Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...
CAPSD_MEVA Capsid protein VP1 (Coat protein VP1) [Cleaved into: Capsid protein VP2 (Coat protein VP2)]

2 entries

Murine minute virus (strain MVMi) (MVM) (Murine parvovirus)

Select_allDeselect_all
NS1_MUMIM Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...
CAPSD_MUMIM Capsid protein VP1 (Coat protein VP1)

2 entries

Parvovirus LuIII

Select_allDeselect_all
NS1_PAVL3 Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...
CAPSD_PAVL3 Capsid protein VP1 (Coat protein VP1)

2 entries

Porcine parvovirus (strain Kresse) (PPV)

Select_allDeselect_all
NS1_PAVPK Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...
CAPSD_PAVPK Capsid protein VP1 (Coat protein VP1)

2 entries

Porcine parvovirus (strain NADL-2) (PPV)

Select_allDeselect_all
NS1_PAVPN Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) ...
CAPSD_PAVPN Capsid protein VP1 (Coat protein VP1)

1 entry

Canine parvovirus type 2 (CPV-2)

CAPSD_PAVC Capsid protein VP2 (Coat protein VP2)

1 entry

Canine parvovirus type 2 (isolate Dog/United States/CPV-b/1978) (CPV-2)

CAPSD_PAVCB Capsid protein VP1 (Coat protein VP1)

1 entry

Canine parvovirus type 2 (strain Dog/United States/780929/-) (CPV-2)

CAPSD_PAVC7 Capsid protein VP1 (Coat protein VP1)

1 entry

Canine parvovirustype 2 (isolate Dog/United States/CPV-d/1988) (CPV-2)

CAPSD_PAVCD Capsid protein VP1 (Coat protein VP1)

1 entry

Feline panleukopenia virus (FPV)

CAPSD_FPV Capsid protein VP1 (Coat protein VP1)

1 entry

Galleria mellonella densovirus (GmDNV)

CAPSD_GMDNV Capsid protein VP1 (Coat protein VP1) (Structural protein VP1)

1 entry

Porcine parvovirus (strain 90HS) (PPV)

CAPSD_PAVP9 Capsid protein VP1 (Coat protein VP1)