Cypovirus

VIRION

Non enveloped, icosahedral virion with a T=2 icosahedral symmetry, about 65 nm in diameter. Pentameric turrets sit on the outside of the capsid. The capsid is composed of only a single shell of protein.

GENOME

Segmented dsRNA linear genome: 10 segments encode for 10-12 proteins. Segments size range from 1 to 4.2 kb. Genome total size is about 25 kb.

GENE EXPRESSION

The dsRNA genome is never completely uncoated, to prevent activation of antiviral state by the cell in response to dsRNA. The viral polymerase lambda3 synthesizes a capped and non-polyadenylated monocistronic mRNA from each dsRNA segment. These capped mRNAs are translocated to the cell cytoplasm where they are translated.
NSP5 ORF produces two proteins by ribosomal skipping.

REPLICATION

CYTOPLASMIC

  1. Attachement to host receptors probably mediates endocytosis of virus into host cell.
  2. Particles are partially uncoated in endolysosomes, but not entirely, and penetrate in the cytoplasm.
  3. Early transcription of the dsRNA genome by viral polymerase occurs inside this sub-viral particle (naked core), so that dsRNA is never exposed to the cytoplasm.
  4. Full-length plus-strand transcripts from each of the dsRNA segments are synthesized. These plus-strand transcripts are used as templates for translation.
  5. Viral proteins and genomic RNAs aggregates in cytoplasmic viral factories.
  6. (+)RNAs are encapsidated in a sub-viral particle, in which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
  7. The capsid is assembled on the sub-viral particle.
  8. Mature virions are released presumably following cell death and associated breakdown of host plasma membrane.

Matching UniProtKB/Swiss-Prot entries

15 entries grouped by strain (browse by keywords)

All proteins are shown (view only 10 complete proteome entries)

10 entries

Lymantria dispar cypovirus 1 (isolate Rao) (LdCPV-1) reference strain

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CAPSD_LDCPRMajor capsid protein VP1
NS1_LDCPRNon-structural protein 1 (NS1)
NS3_LDCPRNon-structural protein 3 (NS3)
NS5_LDCPRNon-structural protein 5 (NS5)
PYHD_LDCPRPolyhedrin
RDRP_LDCPRRNA-directed RNA polymerase VP2 (EC 2.7.7.48)
VP3_LDCPRPutative structural protein VP3
VP4_LDCPROuter capsid protein VP4
VP5_LDCPRPutative structural protein VP5
VP6_LDCPRMicrotubule-associated protein VP6

2 entries

Bombyx mori cytoplasmic polyhedrosis virus (BmCPV)

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CAPSD_CPVBMCapsid protein VP1
PYHD_CPVBMPolyhedrin (C-polyhedrin)

1 entry

Choristoneura fumiferana cypovirus (CfCPV) (Choristoneura fumiferana cytoplasmic polyhedrosis virus)


PYHD_CPVCSPolyhedrin (C-polyhedrin)

1 entry

Euxoa scandens cypovirus (EsCPV) (Euxoa scandens cytoplasmic polyhedrosis virus)


PYHD_CPVESPolyhedrin (C-polyhedrin)

1 entry

Orgyia pseudotsugata cypovirus (OpCPV) (Orgyia pseudotsugata cytoplasmic polyhedrosis virus)


PYHD_CPVOPPolyhedrin (C-polyhedrin)