Inoviridae

VIRION

Non-enveloped, rod of filaments of 7nm in diameter and 700 to 2000nm in length. Helical capsid with adsorption proteins on one end.

GENOME

Circular, ssDNA genome (+) of 4.5 to 8kb encoding for 4 to 10 proteins. Replication occurs via dsDNA intermediate and rolling circle.

GENE EXPRESSION

Each gene is transcribed by host cellular machinery, via a specific promoter. Some genes end by a transcription terminator.





REPLICATION

CYTOPLASMIC
  1. Viral g3p protein mediates pilus-mediated adsorption of the virus onto host cell. Pilus retraction pulls the virion to the host internal membrane.
  2. The proteins of the capsid perform the injection of the viral DNA through bacterial membranes into cell cytoplasm.
  3. Host polymerase convert the (+)ssDNA viral genome into a covalently closed dsDNA called replicative form DNA (RF).
  4. dsDNA transcription by host RNA polymerase gives rise to viral mRNAs.
  5. Viral g2p protein nicks RF DNA strand at the origin of replication.
  6. (+) strand replication occurs by rolling circle.
  7. New (+)ssDNA genomes are converted into new RF molecules, and further transcription occurs.
  8. When enough g5p protein is synthesized, conversion into RF dsDNA is inhibited, as neo-synthesized genomic ssDNA is covered with g5p.
  9. g5p are replaced by g8p proteins to trigger the assembly of the viral capsid.
  10. New virions are secreted from host cell.
  11. Infected cells continue to divide and produce virions indefinitely.

replication cycle

  1. Viral g3p protein mediates pilus-mediated adsorption of the virus onto host cell. Pilus retraction pulls the virion to the host internal membrane.
  2. The proteins of the capsid mediate the Injection of the viral DNA through bacterial membranes into cell cytoplasm.
  3. Host polymerase convert the (+)ssDNA viral genome into a covalently closed dsDNA called replicative form DNA (RF).
  4. dsDNA transcription by host RNA polymerase gives rise to viral mRNAs.
  5. Viral g2p protein nicks RF DNA strand at the origin of replication.
  6. (+) strand replication occurs by rolling circle.
  7. New (+)ssDNA genomes are converted into new RF molecules, and further transcription occurs.
  8. When enough g5p protein is synthesized, conversion into RF dsDNA is inhibited, as neo-synthesized genomic ssDNA is covered with g5p.
  9. g5p are replaced by g8p proteins to trigger the assembly of the viral capsid.
  10. New virions are secreted from host cell.
  11. Infected cells continue to divide and produce virions indefinitely.

Matching UniProtKB/Swiss-Prot entries

114 entries grouped by strain (browse by keywords)

All proteins are shown (view only 109 complete proteome entries)

13 entries

Spiroplasma virus SpV1-C74 (SpV1) reference strain

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CAPSD_SPV1CPutative capsid protein ORF9
INTG_SPV1CPutative integrase ORF3
ORF10_SPV1CUncharacterized protein ORF10
ORF11_SPV1CUncharacterized protein ORF11
ORF12_SPV1CUncharacterized protein ORF12
ORF13_SPV1CUncharacterized protein ORF13
ORF14_SPV1CUncharacterized protein ORF14
ORF15_SPV1CUncharacterized protein ORF15
ORF1_SPV1CUncharacterized protein ORF1
ORF2_SPV1CUncharacterized protein ORF2
ORF4_SPV1CUncharacterized protein ORF4
ORF5_SPV1CUncharacterized protein ORF5
ORF7_SPV1CUncharacterized protein ORF7

12 entries

Spiroplasma virus SpV1-R8A2 B (SpV1) (Spiroplasma virus 1) reference strain

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CAPSD_SPV1RPutative capsid protein ORF9 (Gene 9 protein)
INTG_SPV1RPutative integrase ORF3 (Gene 3 protein)
ORF10_SPV1RUncharacterized protein ORF10 (Gene 10 protein)
ORF11_SPV1RUncharacterized protein ORF11 (Gene 11 protein)
ORF12_SPV1RUncharacterized protein ORF12 (Gene 12 protein)
ORF1_SPV1RUncharacterized protein ORF1 (Gene 1 protein)
ORF2_SPV1RUncharacterized protein ORF2 (Gene 2 protein)
ORF4_SPV1RUncharacterized protein ORF4 (Gene 4 protein)
ORF5_SPV1RUncharacterized protein ORF5 (Gene 5 protein)
ORF6_SPV1RUncharacterized protein ORF6 (Gene 6 protein)
ORF7_SPV1RUncharacterized protein ORF7 (Gene 7 protein)
ORF8_SPV1RUncharacterized protein ORF8 (Gene 8 protein)

9 entries

Enterobacteria phage M13 (Bacteriophage M13) reference strain

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CAPSD_BPM13Capsid protein G8P (Coat protein B) (Gene 8 protein) (G8P) (M13 procoat) (Major ...
G1P_BPM13Gene 1 protein (G1P)
G3P_BPM13Attachment protein G3P (Gene 3 protein) (G3P) (Minor coat protein)
G4P_BPM13Virion export protein (Gene 4 protein) (G4P)
G5P_BPM13DNA-Binding protein G5P (G5P) (Single-stranded DNA-binding protein)
G6P_BPM13Head virion protein G6P (Coat protein D) (G6P)
G7P_BPM13Tail virion protein G7P (Coat protein C, polypeptide I) (Gene 7 protein) (G7P)
G9P_BPM13Tail virion protein G9P (Coat protein C, polypeptide II) (G9P)
REP_BPM13Replication-associated protein G2P (Rep) (EC 3.1.21.-) (EC 6.5.1.1) (G2P) (Gene ...

14 entries

Pseudomonas phage Pf1 (Bacteriophage Pf1)

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CAPSD_BPPF1Capsid protein G8P (Coat protein B) (Gene 8 protein) (G8P) (Major coat protein)
G3P_BPPF1Attachment protein G3P (Gene 3 protein) (G3P) (Minor coat protein)
G5P_BPPF1DNA-Binding protein G5P (G5P) (GPV) (Single-stranded DNA-binding protein)
G6P_BPPF1Head virion protein G6P (Coat protein D) (G6P)
INTG_BPPF1Putative integrase
VG030_BPPF13.2 kDa protein (ORF 30)
VG071_BPPF18.6 kDa protein (ORF 71)
VG083_BPPF1Uncharacterized protein ORF83 (ORF083)
VG090_BPPF110.1 kDa protein (ORF 90)
VG096_BPPF110.9 kDa protein (ORF 96)
VG103_BPPF111.2 kDa protein (ORF 103)
VG110_BPPF112.0 kDa protein (ORF 110)
VG424_BPPF1Uncharacterized protein ORF424 (ORF 424)
VG430_BPPF1Uncharacterized protein ORF430 (ORF430)

9 entries

Enterobacteria phage IKe (Bacteriophage IKe)

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CAPSD_BPIKECapsid protein G8P (Coat protein B) (Gene 8 protein) (G8P) (Major coat protein)
G1P_BPIKEGene 1 protein (G1P)
G3P_BPIKEAttachment protein G3P (Gene 3 protein) (G3P) (Minor coat protein)
G4P_BPIKEVirion export protein (Gene 4 protein) (G4P)
G5P_BPIKEDNA-Binding protein G5P (G5P) (GPV) (Single-stranded DNA-binding protein)
G6P_BPIKEHead virion protein G6P (Coat protein D) (G6P)
G7P_BPIKETail virion protein G7P (Coat protein C, polypeptide I) (Gene 7 protein) (G7P)
G9P_BPIKETail virion protein G9P (Coat protein C, polypeptide II) (G9P)
REP_BPIKEReplication-associated protein G2P (Rep) (EC 3.1.21.-) (EC 6.5.1.1) (G2P) (Gene ...

9 entries

Enterobacteria phage If1 (Bacteriophage If1)

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CAPSD_BPIF1Capsid protein G8P (Coat protein B) (Gene 8 protein) (G8P) (Major coat protein)
G1P_BPIF1Gene 1 protein (G1P)
G3P_BPIF1Attachment protein G3P (Gene 3 protein) (G3P) (Minor coat protein)
G4P_BPIF1Virion export protein (Gene 4 protein) (G4P)
G5P_BPIF1DNA-Binding protein G5P (G5P) (GPV) (Single-stranded DNA-binding protein)
G6P_BPIF1Head virion protein G6P (Coat protein D) (G6P)
G7P_BPIF1Tail virion protein G7P (Coat protein C, polypeptide I) (Gene 7 protein) (G7P)
G9P_BPIF1Tail virion protein G9P (Coat protein C, polypeptide II) (G9P)
REP_BPIF1Replication-associated protein G2P (Rep) (EC 3.1.21.-) (EC 6.5.1.1) (G2P) (Gene ...

9 entries

Enterobacteria phage f1 (Bacteriophage f1)

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CAPSD_BPF1Capsid protein G8P (Coat protein B) (Gene 8 protein) (G8P) (Major coat protein)
G1P_BPF1Gene 1 protein (G1P)
G3P_BPF1Attachment protein G3P (Gene 3 protein) (G3P) (Minor coat protein)
G4P_BPF1Virion export protein (Gene 4 protein) (G4P)
G5P_BPF1DNA-Binding protein G5P (G5P) (GPV) (Single-stranded DNA-binding protein)
G6P_BPF1Head virion protein G6P (Coat protein D) (G6P)
G7P_BPF1Tail virion protein G7P (Coat protein C, polypeptide I) (Gene 7 protein) (G7P)
G9P_BPF1Tail virion protein G9P (Coat protein C, polypeptide II) (G9P)
REP_BPF1Replication-associated protein G2P (Rep) (EC 3.1.21.-) (EC 6.5.1.1) (G2P) (Gene ...

9 entries

Enterobacteria phage fd (Bacteriophage fd)

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CAPSD_BPFDCapsid protein G8P (Coat protein B) (Gene 8 protein) (G8P) (Major coat protein)
G1P_BPFDGene 1 protein (G1P)
G3P_BPFDAttachment protein G3P (Gene 3 protein) (G3P) (Minor coat protein)
G4P_BPFDVirion export protein (Gene 4 protein) (G4P)
G5P_BPFDDNA-Binding protein G5P (G5P) (GPV) (Single-stranded DNA-binding protein)
G6P_BPFDHead virion protein G6P (Coat protein D) (G6P)
G7P_BPFDTail virion protein G7P (Coat protein C, polypeptide I) (Gene 7 protein) (G7P)
G9P_BPFDTail virion protein G9P (Coat protein C, polypeptide II) (G9P)
REP_BPFDReplication-associated protein G2P (Rep) (EC 3.1.21.-) (EC 6.5.1.1) (G2P) (Gene ...

9 entries

Pseudomonas phage Pf3 (Bacteriophage Pf3)

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CAPSD_BPPF3Capsid protein G8P (Coat protein B) (Gene 8 protein) (G8P) (Major coat protein) ...
G3P_BPPF3Attachment protein G3P (Gene 3 protein) (G3P) (Minor coat protein)
G5P_BPPF3DNA-Binding protein G5P (G5P) (Single-stranded DNA-binding protein)
G6P_BPPF3Head virion protein G6P (Coat protein D) (G6P)
REP_BPPF3Replication-associated protein G2P (Rep) (EC 3.1.21.-) (EC 6.5.1.1) (G2P) (Gene ...
VG058_BPPF36.4 kDa protein (ORF 58)
VG071_BPPF37.9 kDa protein (ORF 71)
VG301_BPPF3Putative assembly protein ORF301 (ORF301)
VG430_BPPF3Putative assembly protein ORF430 (ORF430)

8 entries

Enterobacteria phage I2-2 (Bacteriophage I2-2)

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CAPSD_BPI22Capsid protein G8P (Coat protein B) (Gene 8 protein) (G8P) (Major coat protein)
G1P_BPI22Gene 1 protein (G1P)
G3P_BPI22Attachment protein G3P (Gene 3 protein) (G3P) (Minor coat protein)
G4P_BPI22Virion export protein (Gene 4 protein) (G4P)
G5P_BPI22DNA-Binding protein G5P (G5P) (Single-stranded DNA-binding protein)
G7P_BPI22Tail virion protein G7P (Coat protein C, polypeptide I) (Gene 7 protein) (G7P)
G9P_BPI22Tail virion protein G9P (Coat protein C, polypeptide II) (G9P)
REP_BPI22Replication-associated protein G2P (Rep) (EC 3.1.21.-) (EC 6.5.1.1) (G2P) (Gene ...

8 entries

Xanthomonas phage phiLf (Bacteriophage phi-Lf)

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CAPSD_BPPHLCapsid protein G8P (Coat protein B) (Gene 8 protein) (G8P) (Major coat protein)
G1P_BPPHLGene 1 protein (G1P)
G3P_BPPHLAttachment protein G3P (Gene 3 protein) (G3P) (Minor coat protein)
G5P_BPPHLDNA-Binding protein G5P (G5P) (Single-stranded DNA-binding protein)
G6P_BPPHLHead virion protein G6P (Coat protein D) (G6P)
G7P_BPPHLTail virion protein G7P (Coat protein C, polypeptide I) (Gene 7 protein) (G7P)
G9P_BPPHLTail virion protein G9P (Coat protein C, polypeptide II) (G9P)
REP_BPPHLReplication-associated protein G2P (Rep) (EC 3.1.21.-) (EC 6.5.1.1) (G2P) (Gene ...

2 entries

Shigella phage SfX (Shigella flexneri bacteriophage X) (Bacteriophage SfX)

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GTRA_BPSFXBactoprenol-linked glucose translocase
GTRB_BPSFXBactoprenol glucosyl transferase (EC 2.4.1.-)

1 entry

Enterobacteria phage ZJ/2 (Bacteriophage ZJ-2)


CAPSD_BPZJ2Capsid protein G8P (Coat protein B) (Gene 8 protein) (G8P) (Major coat protein)

1 entry

Thermus phage PH75 (Bacteriophage PH75)


CAPSD_BPH75Capsid protein G8P (Coat protein B) (Gene 8 protein) (G8P) (Major coat protein)

1 entry

Xanthomonas phage Xf (Bacteriophage Xf)


CAPSD_BPXFCapsid protein G8P (Coat protein B) (Gene 8 protein) (G8P) (Major coat protein)