Avipoxvirus

VIRION

Enveloped, brick-shpaed 330×280x200nm. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).

GENOME

Linear, dsDNA genome about 300kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.
Canarypox virus strain ATCC VR111 genome at Poxvirus Bioinformatics Ressource center

GENE EXPRESSION

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).

Host-virus interaction

Apoptosis modulation

FPV039 inhibits apoptosis by sequestering and inactivating multiple proapoptotic Bcl-2 proteins, including Bak and Bax .

Matching UniProtKB/Swiss-Prot entries

151 entries grouped by strain (browse by keywords)

All proteins are shown (view only 149 complete proteome entries)

149 entries

Fowlpox virus (strain NVSL) (FPV) reference strain

Select_all Deselect_all  
3BHS_FOWPN3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase (3-beta-HSD)
A11_FOWPNProtein A11 homolog
A13_FOWPNVirion membrane protein A13 homolog
A14_FOWPNVirion membrane protein A14 homolog
A15_FOWPNCore protein A15 homolog
A16_FOWPNVirion membrane protein A16 homolog
A17_FOWPNVirion membrane protein A17 precursor homolog
A18_FOWPNTranscript termination protein A18 (EC 3.6.4.-)
A19_FOWPNProtein A19 homolog
A21_FOWPNVirion membrane protein A21 homolog
A28_FOWPNEnvelope protein A28 homolog (Protein FPV192)
A30_FOWPNProtein A30 homolog
A6_FOWPNProtein A6 homolog
A9_FOWPNProtein A9 homolog
D10_FOWPNmRNA-decapping protein D10 (EC 3.1.3.-)
D13_FOWPNScaffold protein D13 ortholog (62 kDa protein) (Rifampicin resistance protein)
D3_FOWPN27 kDa core protein
D5_FOWPNPrimase D5 (EC 3.6.4.-)
D9_FOWPNPutative Nudix hydrolase FPV054 (EC 3.6.-.-)
DCK1_FOWPNProbable deoxycytidine kinase FPV059 (dCK) (EC 2.7.1.74)
DCK2_FOWPNProbable deoxycytidine kinase FPV151 (dCK) (EC 2.7.1.74)
DNLI_FOWPNDNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase
DPOL_FOWPNDNA polymerase (EC 2.7.7.7)
DUSP_FOWPNProbable dual specificity protein phosphatase H1 homolog (EC 3.1.3.-) (EC ...
DUT_FOWPNDeoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
E11_FOWPNProtein E11 homolog
E2_FOWPNProtein E2 homolog
E6_FOWPNProtein E6 homolog
ETF1_FOWPNEarly transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase ...
ETF2_FOWPNEarly transcription factor 82 kDa subunit (ETF large subunit)
F11_FOWPNProtein F11 homolog
F12_FOWPNVirion release protein (Protein F12 homolog)
F13_FOWPNEnvelope protein F13 homolog (43 kDa protein) (p43K)
F15_FOWPNProtein F15
F17_FOWPNCore phosphoprotein F17
G3_FOWPNProtein G3 homolog (Protein FPV078)
H7_FOWPNLate protein H7 homolog
I1_FOWPNTelomere-binding protein I1 homolog (Protein FPV90)
I2_FOWPNProtein I2 homolog (Protein FPV089)
I5L_FOWPNProtein I5 homolog
I6_FOWPNTelomere-binding protein I6 homolog (Protein FPV084)
I7_FOWPNCore protease I7 homolog (EC 3.4.22.-) (Protein FPV083)
J1_FOWPNProtein J1 homolog (Protein FPV133)
J5_FOWPNProtein J5 homolog (FPV136)
KITH_FOWPNThymidine kinase (EC 2.7.1.21)
L1_FOWPNProtein L1 homolog (Virion membrane protein M25)
L2_FOWPNProtein FPV129
L5_FOWPNL5 homolog (Protein FPV132)
MCEL_FOWPNmRNA-capping enzyme catalytic subunit (Virus termination factor large subunit) ...
MCES_FOWPNmRNA-capping enzyme small subunit (mRNA (guanine-N(7)-)-methyltransferase) (EC ...
MCE_FOWPNCap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) (Poly(A) ...
MP44_FOWPNProbable metalloendopeptidase G1-type (EC 3.4.24.-)
NPH2_FOWPNRNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (NTPase II) ...
NTP1_FOWPNNucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate ...
O1_FOWPNProtein O1 homolog (Protein FPV091)
P4A_FOWPNMajor core protein 4a precursor (p4a) (Virion core protein 4a precursor)
P4B_FOWPNMajor core protein 4b (Virion core protein 4b) (p4b)
PAP1_FOWPNPoly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large ...
RAP94_FOWPNRNA polymerase-associated transcription-specificity factor RAP94 (Protein H4) ...
RP07_FOWPNDNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6)
RP132_FOWPNDNA-directed RNA polymerase 132 kDa polypeptide (EC 2.7.7.6)
RP147_FOWPNDNA-directed RNA polymerase 147 kDa polypeptide (EC 2.7.7.6)
RP18_FOWPNDNA-directed RNA polymerase 18 kDa subunit (EC 2.7.7.6)
RP19_FOWPNDNA-directed RNA polymerase 19 kDa subunit (EC 2.7.7.6)
RP22_FOWPNDNA-directed RNA polymerase 22 kDa subunit (EC 2.7.7.6)
RP35_FOWPNDNA-directed RNA polymerase 35 kDa subunit (EC 2.7.7.6)
RPO5_FOWPNDNA-directed RNA polymerase 30 kDa polypeptide (EC 2.7.7.6)
RUVV_FOWPNHolliday junction resolvase (EC 3.1.-.-)
UNG_FOWPNUracil-DNA glycosylase (UDG) (EC 3.2.2.27)
V001_FOWPNPutative C-type lectin protein FPV001/FPV260
V002_FOWPNUncharacterized protein FPV002/FPV259
V003_FOWPNPutative C-type lectin protein FPV003/FPV258
V006_FOWPNUncharacterized protein FPV006/FPV255 (BamHI-ORF1)
V007_FOWPNUncharacterized protein FPV007/FPV254
V008_FOWPNPutative C-type lectin protein FPV008/FPV253 (BamHI-ORF2)
V009_FOWPNUncharacterized protein FPV009/FPV252 (ORF b)
V010_FOWPNUncharacterized serpin-like protein FPV010
V011_FOWPNSoluble NSF attachment protein homolog FPV011
V012_FOWPNPutative ankyrin repeat protein FPV012
V014_FOWPNPutative ankyrin repeat protein FPV014
V018_FOWPNPutative ankyrin repeat protein FPV018
V021_FOWPNG-protein coupled receptor homolog FPV021
V022_FOWPNPutative ankyrin repeat protein FPV022
V023_FOWPNPutative ankyrin repeat protein FPV023
V024_FOWPNPutative ankyrin repeat protein FPV024
V026_FOWPNPutative ankyrin repeat protein FPV026
V027_FOWPNG-protein coupled receptor homolog FPV027
V029_FOWPNPutative peptidyl-tRNA hydrolase (PTH) (EC 3.1.1.29)
V031_FOWPNPutative ankyrin repeat protein FPV031
V033_FOWPNSoluble NSF attachment protein homolog FPV033
V034_FOWPNPutative ankyrin repeat protein FPV034
V039_FOWPNBcl-2-like protein FPV039
V040_FOWPNUncharacterized serpin-like protein FPV040
V042_FOWPNUncharacterized protein FPV042
V044_FOWPNUncharacterized serpin-like protein FPV044
V045_FOWPNUncharacterized protein FPV045
V055_FOWPNPutative Ig-like V-type domain-containing protein FPV055 (Protein Y)
V060_FOWPNPutative CC-type chemokine FPV060
V061_FOWPNPutative CC-type chemokine FPV061
V063_FOWPNProtein FPV063 (FPLeft)
V093_FOWPNProbable FAD-linked sulfhydryl oxidase FPV093 (EC 1.8.3.2)
V111_FOWPNProbable serine/threonine-protein kinase FPV111 (EC 2.7.11.1)
V117_FOWPNProtein FPV117
V127_FOWPNProtein FPV127
V130_FOWPNProtein FPV130
V155_FOWPNPutative ankyrin repeat protein FPV115
V162_FOWPNPutative ankyrin repeat protein FPV162
V195_FOWPNProtein FPV195
V198_FOWPNPutative C-type lectin protein FPV198
V204_FOWPNUncharacterized serpin-like protein FPV204
V206_FOWPNG-protein coupled receptor homolog FPV206
V211_FOWPNProbable growth factor FPV211
V212_FOWPNProbable serine/threonine-protein kinase FPV212 (EC 2.7.11.1)
V216_FOWPNPutative ankyrin repeat protein FPV216
V218_FOWPNPutative ankyrin repeat protein FPV218
V219_FOWPNPutative ankyrin repeat protein FPV219
V220_FOWPNUncharacterized protein FPV220
V222_FOWPNPutative ankyrin repeat protein FPV222
V223_FOWPNPutative ankyrin repeat protein FPV223
V224_FOWPNPutative ankyrin repeat protein FPV224
V226_FOWPNProbable serine/threonine-protein kinase FPV226 (EC 2.7.11.1)
V227_FOWPNPutative ankyrin repeat protein FPV227
V228_FOWPNPutative ankyrin repeat protein FPV228
V230_FOWPNPutative ankyrin repeat protein FPV230
V231_FOWPNPutative ankyrin repeat protein FPV231
V232_FOWPNPutative ankyrin repeat protein FPV232
V233_FOWPNPutative ankyrin repeat protein FPV233
V234_FOWPNPutative ankyrin repeat protein FPV234 (BamHI-ORF12/ORF13)
V235_FOWPNPutative protein FPV235 (BamHI-ORF11)
V236_FOWPNUncharacterized protein FPV236 (BamHI-ORF10)
V237_FOWPNUncharacterized protein FPV237 (BamHI-ORF9)
V238_FOWPNUncharacterized protein FPV238 (ORF f)
V239_FOWPNPutative C-type lectin protein FPV239 (BamHI-ORF8)
V240_FOWPNPutative ankyrin repeat protein FPV240 (BamHI-ORF7)
V241_FOWPNPutative ankyrin repeat protein FPV241
V242_FOWPNPutative ankyrin repeat protein FPV242
V243_FOWPNPutative ankyrin repeat protein FPV243
V244_FOWPNPutative ankyrin repeat protein FPV244
V245_FOWPNPutative ankyrin repeat protein FPV245
V246_FOWPNPutative ankyrin repeat protein FPV246
V248_FOWPNUncharacterized protein FPV248 (BamHI-ORF6)
V249_FOWPNUncharacterized protein FPV249 (BamHI-ORF5)
V250_FOWPNUncharacterized protein FPV250 (BamHI-ORF4)
V251_FOWPNUncharacterized serpin-like protein FPV251
VLTF1_FOWPNLate transcription factor 1 (VLTF-1)
VLTF2_FOWPNViral late gene transcription factor 2 (VLTF-2) (Trans-activator protein A1)
VLTF3_FOWPNViral late gene transcription factor 3 (VLTF-3)
VP35_FOWPNImmunodominant envelope protein p35 (Ag35) (Virion envelope protein p35)
VP8_FOWPNCore protein VP8 (25 kDa major core protein) (L4 core protein) (P25K)

2 entries

Canarypox virus (CNPV)

Select_all Deselect_all  
D3_CNPV27 kDa core protein
PAP1_CNPVPoly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large ...